X0407 4 2023-05-02 0 0001818331 GeneDx Holdings Corp. WGS 0000943431 RUCH JOSHUA C/O GENEDX HOLDINGS CORP. 333 LUDLOW ST, NORTH TOWER, 6TH FL. STAMFORD CT 06902 1 0 0 0 0 Class A Common Stock 2023-05-02 4 M 0 45454 0.00 A 62568 D Class A Common Stock 489846 I By Kariba LLC Class A Common Stock 994534 I By RUGU2 LLC Class A Common Stock 4926334 I By VAAL Investment Partners Q9 LP Restricted Stock Unit 2023-05-02 4 M 0 45454 0.00 D Class A Common Stock 45454 0 D Mr. Ruch is (i) a managing member of the managing member of the general partner of Vaal Investment Partners Q9 LP ("Q9"), (ii) a managing member of RUGU2 LLC ("RUGU2") and (iii) a managing member of Kariba LLC ("Kariba"). As such, Mr. Ruch exercises voting and investment power with respect to the shares owned by Q9, RUGU2 and Kariba. Mr. Ruch disclaims beneficial ownership of such securities, except to the extent of his pecuniary interest therein. Each restricted stock unit represents a contingent right to receive 1 share of the Issuer's Class A Common Stock upon settlement for no consideration. The underlying shares shall vest on the earlier of the (a) date of the 2023 annual meeting of the Issuer's stockholders, and (b) first anniversary of the grant date, subject to the Reporting Person continuing to provide services to the Issuer on the applicable vesting date. For avoidance of doubt, all numbers above are presented before giving effect to the 33:1 reverse stock split the Issuer's stockholders approved on April 14, 2023, which was previously disclosed in the Current Reports on Form 8-K filed by the Issuer on April 17, 2023 and April 28, 2023, and which shall become effective on May 4, 2023. /s/ Eunkyung Lee, Attorney-in-Fact 2023-05-04