X0202 4 2007-12-10 0 0000939767 EXELIXIS INC EXEL 0001202102 SCANGOS GEORGE A C/O EXELIXIS INC. 170 HARBOR WAY, PO BOX 511 SOUTH SAN FRANCISCO CA 94083-0511 1 1 0 0 President & CEO Common Stock 2007-12-10 4 S 0 100 8.58 D 1279315 D Common Stock 2007-12-10 4 S 0 100 8.64 D 1279215 D Common Stock 2007-12-10 4 S 0 200 8.63 D 1279015 D Common Stock 2007-12-10 4 S 0 100 8.65 D 1278915 D Common Stock 2007-12-10 4 S 0 200 8.68 D 1278715 D Common Stock 2007-12-10 4 S 0 200 8.61 D 1278515 D Common Stock 2007-12-10 4 S 0 200 8.60 D 1278315 D Common Stock 2007-12-10 4 S 0 200 8.69 D 1278115 D Common Stock 2007-12-10 4 S 0 100 8.65 D 1278015 D Common Stock 2007-12-10 4 S 0 100 8.68 D 1277915 D Common Stock 2007-12-10 4 S 0 200 8.66 D 1277715 D Common Stock 2007-12-10 4 S 0 200 8.74 D 1277515 D Common Stock 2007-12-10 4 S 0 100 8.7 D 1277415 D Common Stock 2007-12-10 4 S 0 100 8.71 D 1277315 D Common Stock 2007-12-10 4 S 0 100 8.58 D 1277215 D Common Stock 2007-12-10 4 S 0 100 8.54 D 1277115 D Common Stock 2007-12-10 4 S 0 100 8.52 D 1277015 D Common Stock 2007-12-10 4 S 0 100 8.59 D 1276915 D Common Stock 8963 I By Trust Common Stock 8963 I By Trust Common Stock 3095 I By 401(k) Plan The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 17, 2007. Shares held by George A. Scangos and Leslie S. Wilson, as Trustees of the Katherine Scangos Trust. Shares held by George A. Scangos and Leslie S. Wilson, as Trustees of the Jennifer Scangos Trust. Represents units in the Exelixis stock fund based on a plan statement dated November 1, 2007. /s/ George A. Scangos 2007-12-11