X0202 SCHEDULE 13D/A 0000909661 XXXXXXXX LIVE 8 Common Stock, par value $0.001 per share (the "Shares") 08/14/2026 0000939767 30161Q104 EXELIXIS, INC.

1851 Harbor Bay Parkway Alameda CA 94502

Hannah E. Dunn (415) 421-2132 Farallon Capital Management, L.L.C. One Maritime Plaza, Suite 2100 San Francisco CA 94111 0000909661 N Farallon Capital Management, L.L.C. AF DE 0 13989010 0 13989010 13989010 5.6 IA OO Y Farallon Capital Partners, L.P. AF CA 0 0 0 0 0 0 PN Y Farallon Capital Institutional Partners, L.P. AF CA 0 0 0 0 0 0 PN Y Farallon Capital Institutional Partners II, L.P. AF CA 0 0 0 0 0 0 PN Y Farallon Capital Institutional Partners III, L.P. AF DE 0 0 0 0 0 0 PN Y Four Crossings Institutional Partners V, L.P. AF DE 0 0 0 0 0 0 PN Y Farallon Capital Offshore Investors II, L.P. AF E9 0 0 0 0 0 0 PN Y Farallon Capital (AM) Investors, L.P. AF DE 0 0 0 0 0 0 PN Y Farallon Capital F5 Master I, L.P. AF E9 0 0 0 0 0 0 PN Y Farallon Healthcare Partners Master, L.P. AF E9 0 0 0 0 0 0 PN Y Farallon Partners, L.L.C. AF DE 0 0 0 0 0 0 OO Y Farallon Institutional (GP) V, L.L.C. AF DE 0 0 0 0 0 0 OO Y Farallon F5 (GP), L.L.C. AF DE 0 0 0 0 0 0 OO Y Farallon Healthcare Partners (GP), L.L.C. AF DE 0 0 0 0 0 0 OO Y Dapice Joshua J. AF X1 0 13989010 0 13989010 13989010 5.6 IN Y Dreyfuss, Philip D. AF X1 0 13989010 0 13989010 13989010 5.6 IN Y Dunn Hannah E. AF X1 0 13989010 0 13989010 13989010 5.6 IN Y Gehani, Varun N. AF X1 0 13989010 0 13989010 13989010 5.6 IN Y Giauque, Nicolas AF I0 0 13989010 0 13989010 13989010 5.6 IN Y Husen, Avner A. AF X1 0 13989010 0 13989010 13989010 5.6 IN Y Kim, David T. AF X1 0 13989010 0 13989010 13989010 5.6 IN Y Linn, Michael G. AF X1 0 13989010 0 13989010 13989010 5.6 IN Y Luo Patrick (Cheng) AF F4 0 13989010 0 13989010 13989010 5.6 IN Y Roberts, Jr., Thomas G. AF X1 0 13989010 0 13989010 13989010 5.6 IN Y Saito Edric C. AF X1 0 13989010 0 13989010 13989010 5.6 IN Y Short Daniel S. AF X1 0 13989010 0 13989010 13989010 5.6 IN Y Spokes, Andrew J. M. AF X0 0 13989010 0 13989010 13989010 5.6 IN Y Warren, John R. AF X1 0 13989010 0 13989010 13989010 5.6 IN Y Wehrly, Mark C. AF X1 0 13989010 0 13989010 13989010 5.6 IN Common Stock, par value $0.001 per share (the "Shares") EXELIXIS, INC. 1851 Harbor Bay Parkway Alameda CA 94502 This Amendment No. 8 to Schedule 13D (this "Amendment") hereby amends and restates Item 2(a) in its entirety, to read as follows: "This Schedule 13D is filed by the entity and persons listed below, all of whom together are referred to herein as the "Reporting Persons." (i) Farallon Capital Management, L.L.C., a Delaware limited liability company (the "Investment Manager"), which is the investment manager of certain investment vehicles and partnerships, including the Farallon Funds (as defined in Item 5), with respect to the Shares held by the Farallon Funds; and (ii) The following persons, each of whom is a managing member or senior managing member, as the case may be, of the Investment Manager, with respect to the Shares held by the Farallon Funds: Joshua J. Dapice ("Dapice"); Philip D. Dreyfuss ("Dreyfuss"); Hannah E. Dunn ("Dunn"); Varun N. Gehani ("Gehani"); Nicolas Giauque ("Giauque"); Avner A. Husen ("Husen"); David T. Kim ("Kim"); Michael G. Linn ("Linn"); Patrick (Cheng) Luo ("Luo"); Thomas G. Roberts, Jr. ("Roberts"); Edric C. Saito ("Saito"); Daniel S. Short ("Short"); Andrew J. M. Spokes ("Spokes"); John R. Warren ("Warren"); and Mark C. Wehrly ("Wehrly"). Dapice, Dreyfuss, Dunn, Gehani, Giauque, Husen, Kim, Linn, Luo, Roberts, Saito, Short, Spokes, Warren and Wehrly are together referred to herein as the "Farallon Individual Reporting Persons." This Amendment hereby amends and restates Item 2(b) in its entirety, to read as follows: "The address of the principal business office of each of the Reporting Persons is c/o Farallon Capital Management, L.L.C., One Maritime Plaza, Suite 2100, San Francisco, California 94111." This Amendment hereby amends and restates Item 2(c) in its entirety, to read as follows: "The principal business of the Investment Manager is to act as the investment manager of various investment vehicles and partnerships, including the Farallon Funds. The principal occupation of each Farallon Individual Reporting Person is serving as a managing member or senior managing member, as the case may be, of each of the Investment Manager and Farallon Partners, L.L.C., which is the general partner of certain investment partnerships advised by the Investment Manager, and as a manager or senior manager, as the case may be, of certain other general partners of investment partnerships advised by the Investment Manager." This Amendment hereby amends and restates Item 2(f) in its entirety, to read as follows: "The jurisdiction of organization of the Investment Manager is set forth above. Each of the Farallon Individual Reporting Persons, other than Giauque, Luo and Spokes, is a citizen of the United States. Giauque is a citizen of France. Luo is a citizen of China. Spokes is a citizen of the United Kingdom." This Amendment hereby amends and restates Item 3 in its entirety, to read as follows: "The approximate net investment cost for the Shares held by the Farallon Funds is $308,124,978." This Amendment hereby amends and restates Item 5(a) in its entirety, to read as follows: "The information set forth in Rows 7 through 13 of the cover page hereto for each Reporting Person is incorporated herein by reference for each such Reporting Person. The percentage amount set forth in Row 13 for all cover pages filed herewith is calculated based upon 247,781,692 Shares outstanding as of July 27, 2026, as reported by the Issuer in its Form 10-Q filed with the Securities and Exchange Commission on August 5, 2026. The Shares reported hereby as beneficially owned by the Reporting Persons are held directly by the following investment partnerships, of which the Investment Manager is the investment manager: (i) Farallon Capital Partners, L.P., a California limited partnership ("FCP"); (ii) Farallon Capital Institutional Partners, L.P., a California limited partnership ("FCIP"); (iii) Farallon Capital Institutional Partners II, L.P., a California limited partnership ("FCIP II"); (iv) Farallon Capital Institutional Partners III, L.P., a Delaware limited partnership ("FCIP III"); (v) Farallon Capital Offshore Investors II, L.P., a Cayman Islands exempted limited partnership ("FCOI II"); (vi) Farallon Capital (AM) Investors, L.P., a Delaware limited partnership ("FCAMI"); (vii) Farallon Capital F5 Master I, L.P., a Cayman Islands exempted limited partnership ("F5MI"); and (viii) Farallon Healthcare Partners Master, L.P., a Cayman Islands exempted limited partnership ("FHPM"). FCP, FCIP, FCIP II, FCIP III, FCOI II, FCAMI, F5MI and FHPM are together referred to herein as the "Farallon Funds." This Amendment hereby amends and restates Item 5(b) in its entirety, to read as follows: "The information set forth in Rows 7 through 13 of the cover page hereto for each Reporting Person is incorporated herein by reference for each such Reporting Person." This Amendment hereby amends and restates Item 5(c) in its entirety, to read as follows: "The dates, number of Shares involved and the price per Share (excluding commissions) for all transactions in the Shares by the Farallon Funds in the past sixty days are set forth in Exhibit 1.C attached hereto and such information is incorporated herein by reference. All of such transactions were open-market transactions." This Amendment hereby amends and restates Item 5(d) in its entirety, to read as follows: "The Farallon Funds have the right to receive dividends from, and the proceeds from the sale of, the securities of the Issuer beneficially owned by the Reporting Persons." This Amendment hereby amends and supplements Item 7 by adding the following thereto: "There is filed herewith as Exhibit 1.C the sixty-day trading history referenced in Item 5(c). There is filed herewith as Exhibit 8 a written agreement relating to the filing of joint acquisition statements as required by Rule 13d-1(k) under the Securities Exchange Act of 1934, as amended." Farallon Capital Management, L.L.C. /s/ Hannah E. Dunn 08/14/2026 Farallon Capital Partners, L.P. /s/ Hannah E. Dunn 08/14/2026 Farallon Capital Institutional Partners, L.P. /s/ Hannah E. Dunn 08/14/2026 Farallon Capital Institutional Partners II, L.P. /s/ Hannah E. Dunn 08/14/2026 Farallon Capital Institutional Partners III, L.P. /s/ Hannah E. Dunn 08/14/2026 Four Crossings Institutional Partners V, L.P. /s/ Hannah E. Dunn 08/14/2026 Farallon Capital Offshore Investors II, L.P. /s/ Hannah E. Dunn 08/14/2026 Farallon Capital (AM) Investors, L.P. /s/ Hannah E. Dunn 08/14/2026 Farallon Capital F5 Master I, L.P. /s/ Hannah E. Dunn 08/14/2026 Farallon Healthcare Partners Master, L.P. /s/ Hannah E. Dunn 08/14/2026 Farallon Partners, L.L.C. /s/ Hannah E. Dunn 08/14/2026 Farallon Institutional (GP) V, L.L.C. /s/ Hannah E. Dunn 08/14/2026 Farallon F5 (GP), L.L.C. /s/ Hannah E. Dunn 08/14/2026 Farallon Healthcare Partners (GP), L.L.C. /s/ Hannah E. Dunn 08/14/2026 Dapice Joshua J. /s/ Hannah E. Dunn 08/14/2026 Dreyfuss, Philip D. /s/ Hannah E. Dunn 08/14/2026 Dunn Hannah E. /s/ Hannah E. Dunn 08/14/2026 Gehani, Varun N. /s/ Hannah E. Dunn 08/14/2026 Giauque, Nicolas /s/ Hannah E. Dunn 08/14/2026 Husen, Avner A. /s/ Hannah E. Dunn 08/14/2026 Kim, David T. /s/ Hannah E. Dunn 08/14/2026 Linn, Michael G. /s/ Hannah E. Dunn 08/14/2026 Luo Patrick (Cheng) /s/ Hannah E. Dunn 08/14/2026 Roberts, Jr., Thomas G. /s/ Hannah E. Dunn 08/14/2026 Saito Edric C. /s/ Hannah E. Dunn 08/14/2026 Short Daniel S. /s/ Hannah E. Dunn 08/14/2026 Spokes, Andrew J. M. /s/ Hannah E. Dunn 08/14/2026 Warren, John R. /s/ Hannah E. Dunn 08/14/2026 Wehrly, Mark C. /s/ Hannah E. Dunn 08/14/2026 Each of Farallon Partners, L.L.C., Farallon Institutional (GP) V, L.L.C., Farallon F5 (GP), L.L.C, and Farallon Healthcare Partners (GP), L.L.C. has executed this statement in Mill Valley, California, on behalf of itself and each fund for which it is the general partner.