X0306 4 2020-05-29 0 0001582313 Xenon Pharmaceuticals Inc. XENE 0000938801 HOLLER FRANK A 200 - 3650 GILMORE WAY BURNABY A1 V5G 4M1 BRITISH COLUMBIA, CANADA 1 0 0 0 Common Shares 2020-05-29 4 M 0 3086 3.56 A 122041 D Common Shares 1184 I Spouse Stock Option (Right to Buy) 3.56 2020-05-29 4 M 0 3086 0.00 D 2020-06-02 Common Shares 3086 0 D Stock Option (Right to Buy) 13.11 2020-06-01 4 A 0 10000 0.00 A 2030-05-31 Common Shares 10000 10000 D The exercise price was converted from $3.74 CAD using the closing rate of exchange of the Bank of Canada on the date of grant. The actual exercise price is the Canadian dollar amount regardless of the exchange rate on the date of exercise The shares held indirectly by the Reporting Person's spouse were inadvertently omitted from the Form 4 filed on September 20, 2019. The shares subject to the option fully vested on December 31, 2012. The date the options became fully vested was incorrectly reflected on the Reporting Person's Form 3. Expiration date differs from originally reported date due to an automatic extension provided by the option plan as a result of the original expiration date falling during a Company blackout period. One-third of the total shares subject to the Option shall vest on the one year anniversary of the grant date, one-third of the total shares subject to the Option shall vest on the two year anniversary of the grant date, one-third of the total shares subject to the Option shall vest on the three year anniversary of the grant date. /s/ Cassandra Robinson, Attorney-in-fact 2020-06-02