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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 MDVTbwausGaqR+Q3/WiExhXN1jHRtwA1X+1/C8FknEMrkvoXgvBv1bH6dTiN3a8G
 7uFQJUKQDtpWY/CFK5ObGQ==

<SEC-DOCUMENT>0000937889-05-000014.txt : 20050909
<SEC-HEADER>0000937889-05-000014.hdr.sgml : 20050909
<ACCEPTANCE-DATETIME>20050909142050
ACCESSION NUMBER:		0000937889-05-000014
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20050907
FILED AS OF DATE:		20050909
DATE AS OF CHANGE:		20050909

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			SIRNA THERAPEUTICS INC
		CENTRAL INDEX KEY:			0000892112
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				341697351
		STATE OF INCORPORATION:			CO
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		2950 WILDERNESS PLACE
		CITY:			BOULDER
		STATE:			CO
		ZIP:			80301
		BUSINESS PHONE:		3034496500

	MAIL ADDRESS:	
		STREET 1:		2950 WILDERNESS PLACE
		CITY:			BOULDER
		STATE:			CO
		ZIP:			80301

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	RIBOZYME PHARMACEUTICALS INC
		DATE OF NAME CHANGE:	19960306

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			VENROCK ASSOCIATES
		CENTRAL INDEX KEY:			0000937889
		STATE OF INCORPORATION:			NY
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-27914
		FILM NUMBER:		051077368

	BUSINESS ADDRESS:	
		STREET 1:		ROOM 5508
		STREET 2:		30 ROCKEFELLER PLAZA
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10112
		BUSINESS PHONE:		2126495600

	MAIL ADDRESS:	
		STREET 1:		ROOM 5508
		STREET 2:		30 ROCKEFELLER PLAZA
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10112
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>edgar.xml
<DESCRIPTION>PRIMARY DOCUMENT
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2005-09-07</periodOfReport>

    <issuer>
        <issuerCik>0000892112</issuerCik>
        <issuerName>SIRNA THERAPEUTICS INC</issuerName>
        <issuerTradingSymbol>RNAI</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0000937889</rptOwnerCik>
            <rptOwnerName>VENROCK ASSOCIATES</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>30 ROCKEFELLER PLAZA, ROOM 5508</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10112</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2005-09-07</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>J</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
                <footnoteId id="F1"/>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>449948</value>
                </transactionShares>
                <transactionPricePerShare>
                    <footnoteId id="F2"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>908783</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value></value>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">Pro-rata distribution of Common Stock to its partners by Venrock Associates, a limited partnership, of which 908,783 shares of Common Stock have been retained.</footnote>
        <footnote id="F2">Not applicable.</footnote>
    </footnotes>

    <remarks></remarks>

    <ownerSignature>
        <signatureName>Bryan E. Roberts, General Partner</signatureName>
        <signatureDate>2005-09-09</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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