<SEC-DOCUMENT>0001047469-16-015599-index.html : 20160921
<SEC-HEADER>0001047469-16-015599.hdr.sgml : 20160921
<ACCEPTANCE-DATETIME>20160921162100
ACCESSION NUMBER:		0001047469-16-015599
CONFORMED SUBMISSION TYPE:	424B2
PUBLIC DOCUMENT COUNT:		2
FILED AS OF DATE:		20160921
DATE AS OF CHANGE:		20160921

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Shire plc
		CENTRAL INDEX KEY:			0000936402
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				000000000
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		424B2
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-213502
		FILM NUMBER:		161895817

	BUSINESS ADDRESS:	
		STREET 1:		HAMPSHIRE INTL BUSINESS PARK
		STREET 2:		CHINEHAM BASINGSTOKE
		CITY:			HAMPSHIRE ENGLAND RG
		STATE:			X0
		ZIP:			RG24 8EP
		BUSINESS PHONE:		441256894000

	MAIL ADDRESS:	
		STREET 1:		HAMPSHIRE INTL BUSINESS PARK
		STREET 2:		CHINEHAM BASINGSTOKE
		CITY:			HAMPSHIRE ENGLAND RG
		STATE:			X0
		ZIP:			RG24 8EP

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Shire Ltd.
		DATE OF NAME CHANGE:	20080523

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Shire plc
		DATE OF NAME CHANGE:	20051125

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	SHIRE PHARMACEUTICALS GROUP PLC
		DATE OF NAME CHANGE:	19980302

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Shire Acquisitions Investments Ireland DAC
		CENTRAL INDEX KEY:			0001683108
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			L2
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		424B2
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-213502-01
		FILM NUMBER:		161895818

	BUSINESS ADDRESS:	
		STREET 1:		5 RIVERWALK
		STREET 2:		CITYWEST BUSINESS CAMPUS
		CITY:			DUBLIN 24
		STATE:			L2
		ZIP:			00000
		BUSINESS PHONE:		353 1 429 7700

	MAIL ADDRESS:	
		STREET 1:		5 RIVERWALK
		STREET 2:		CITYWEST BUSINESS CAMPUS
		CITY:			DUBLIN 24
		STATE:			L2
		ZIP:			00000
</SEC-HEADER>
<DOCUMENT>
<TYPE>424B2
<SEQUENCE>1
<FILENAME>a2229776z424b2.htm
<DESCRIPTION>424B2
<TEXT>
Document 1 - file: a2229776z424b2.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>2
<FILENAME>g867082.jpg
<DESCRIPTION>G867082.JPG
<TEXT>
Document 2 - file: g867082.jpg

</DOCUMENT>
</SEC-DOCUMENT>