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Share-based Compensation Plans (Tables)
12 Months Ended
Dec. 31, 2015
Disclosure of Compensation Related Costs, Share-based Payments [Abstract]  
Share-based Compensation Expense
    
Year to December 31,201520142013
 $’M$’M$’M
 ____________________________________
Cost of product sales7.68.54.4
Research and development28.622.222.8
Selling, general and administrative37.435.946.9
Reorganization costs26.730.43.3
 ____________________________________
Total 100.397.077.4
Less tax(28.4)(23.8)(18.1)
 ____________________________________
 71.973.259.3
 ____________________________________
Share-based Awards Outstanding
 Compensation typeNumber of awards*Expiration period from date of issueVesting period
 ________________________________________________
SARsSARs7,326,7987 years3 years graded vesting and/or 3 years cliff vesting subject to performance criteria for Executive Directors only
UK/Irish Sharesave PlansStock options 113,6196 months after vesting3 or 5 years
Global Employee Stock Purchase PlanStock options 356,079On vesting date1 to 5 years
     
  __________________  
Stock-settled SARs and stock options7,796,496  
  __________________  
RSUs, PSUs and PSAsRSUs, PSUs and PSAs 1,791,9303 years3 years graded vesting, 3 years cliff vesting subject to performance criteria for Executive Directors and certain senior employees only 
  __________________  
Restricted/Performance stock units and Performance share awards1,791,930  
  __________________  
Summary of Status of Stock Appreciation Rights and Stock Options
 Weighted average exercise price   
Year to December 31, 2015£Number of Intrinsic value
  shares*£’ M
 _____________________________________________
Outstanding as at beginning of period33.277,756,516 
Granted52.124,444,345 
Exercised50.99(3,104,782) 
Forfeited40.69(1,299,583) 
 ______________________________________________
Outstanding as at end of period52.027,796,49698.5
 ______________________________________________
Exercisable as at end of period35.612,408,24154.8
 ______________________________________________
Schedule of Stock Appreciation Rights and Stock Options Outstanding, by Exercise Price Range
Number of awards outstanding*Exercise pricesWeighted Average remaining contractual term (Years)Weighted average exercise price of awards outstanding Number of awards exercisableWeighted average exercise price of awards exercisable
 £ £ £
_________________________________________________________________________________
      
3,307,72314.01-28.003.720.611,953,62720.43
1,019,98528.01-40.005.236.06264,64636.01
3,468,78840.01-53.875.346.05189,96853.27
________________   _____________ 
7,796,496   2,408,241 
________________   _____________ 
Schedule of Performance Share Awards
RSUs, PSUs and PSAsNumber of shares*Aggregate intrinsic value £’MWeighted average remaining life
 _____________________________________________
Outstanding as at beginning of period 2,166,181  
Granted 1,075,254  
Exercised(975,895)  
Forfeited(473,610)  
 _______________  
Outstanding as at end of period 1,791,93084.25.4
 ______________________________________________
Exercisable as at end of period -N/AN/A
 _____________________________________________
Schedule of Share-based Payment Award, Valuation Assumptions
Period ended December 31, 201520142013
 __________________________________________
Risk-free interest rate10.6-1.8%0.3-1.8%0.1-0.9%
Expected dividend yield0.2-0.4%0.2-0.4%0.4-0.6%
Expected life1-4 years1-4 years1-4 years
Volatility23-26%23-27%23-26%
Forfeiture rate5-7%5-7%5-9%