Consolidated Statements of Operations - USD ($) shares in Millions, $ in Millions	3 Months Ended		9 Months Ended
	Sep. 30, 2017	Sep. 30, 2016	Sep. 30, 2017	Sep. 30, 2016
Revenues:
Product sales	$ 3,533.8	$ 3,315.4	$ 10,537.9	$ 7,264.8
Royalties and other revenues	163.8	136.7	477.8	325.7
Total revenues	3,697.6	3,452.1	11,015.7	7,590.5
Costs and expenses:
Cost of sales	1,001.4	1,736.2	3,437.3	2,762.9
Research and development	402.8	511.1	1,324.5	1,023.0
Selling, general and administrative	859.7	875.6	2,647.7	2,025.8
Amortization of acquired intangible assets	482.4	354.9	1,280.5	702.5
Integration and acquisition costs	237.0	284.5	696.7	738.6
Reorganization costs	5.4	101.4	24.5	115.7
Loss/(gain) on sale of product rights	0.3	(5.7)	(0.4)	(12.2)
Total operating expenses	2,989.0	3,858.0	9,410.8	7,356.3
Operating income/(loss) from continuing operations	708.6	(405.9)	1,604.9	234.2
Interest income	1.5	9.3	5.7	11.9
Interest expense	(141.8)	(186.9)	(425.4)	(318.8)
Other (expense)/income, net	(0.2)	(13.7)	6.8	(16.2)
Total other expense, net	(140.5)	(191.3)	(412.9)	(323.1)
Income/(loss) from continuing operations before income taxes and equity in (losses)/earnings of equity method investees	568.1	(597.2)	1,192.0	(88.9)
Income taxes	(13.5)	229.6	(44.6)	218.4
Equity in (losses)/earnings of equity method investees, net of taxes	(3.4)	(0.9)	0.1	(1.9)
Income/(loss) from continuing operations, net of taxes	551.2	(368.5)	1,147.5	127.6
(Loss)/gain from discontinued operations, net of taxes	(0.4)	(18.3)	18.6	(257.5)
Net income/(loss)	$ 550.8	$ (386.8)	$ 1,166.1	$ (129.9)
Earnings/(loss) per Ordinary Share – basic
Earnings/(loss) from continuing operations (in usd per share)	$ 0.61	$ (0.41)	$ 1.27	$ 0.18
(Loss)/gain from discontinued operations (in usd per share)	0.00	(0.02)	0.02	(0.36)
Earnings/(loss) per Ordinary Share - basic (in usd per share)	0.61	(0.43)	1.29	(0.18)
Earnings/(loss) per Ordinary Share – diluted
Earnings/(loss) from continuing operations (in usd per share)	0.60	(0.41)	1.26	0.18
(Loss)/earnings from discontinued operations (in usd per share)	0.00	(0.02)	0.02	(0.36)
Earnings/(loss) per Ordinary Share - diluted (in usd per share)	$ 0.60	$ (0.43)	$ 1.28	$ (0.18)
Weighted average number of shares:
Basic (in shares)	907.2	900.2	905.9	725.5
Diluted (in shares)	911.6	900.2	912.1	725.5