Exhibit 4.5


                   AMENDMENT TO REGISTRATION RIGHTS AGREEMENT
                             DATED FEBRUARY 18, 1999

     THIS AMENDMENT (this  "Amendment")  to the  REGISTRATION  RIGHTS  AGREEMENT
DATED FEBRUARY 18, 1999 (the "Agreement"), a copy of which is attached hereto as
Exhibit A, is made by and  between  MIRAVANT  MEDICAL  TECHNOLOGIES,  a Delaware
corporation  ("Miravant") and PHARMACIA & UPJOHN,  INC., a Delaware  corporation
("Purchaser"),  effective as of September 2, 2003 (the  "Effective  Date").  Any
defined terms used in this Amendment shall,  unless otherwise  stated,  have the
meaning ascribed to such terms in the Agreement.

1. The term  "Securities"  is hereby amended to include Three Hundred and Ninety
Thousand (390,000) shares (the "Shares") of the Common Stock of MIRAVANT MEDICAL
TECHNOLOGIES  issued to Pharmacia  AB, a Swedish  Corporation,  on the Effective
Date.

2.  The  terms  "register,"   "registered,"  and   "registration"   refer  to  a
registration  effected  by  preparing  and filing a  registration  statement  or
similar  document  in  compliance  with the 1933  Act,  and the  declaration  or
ordering of effectiveness of such registration statement or document.

3. Sections 2.1 and 2.2 of the Agreement are hereby  deleted in their  entirety,
and are replaced by the following provisions:

     "2.1.Miravant  shall include the Shares in the filing of  Miravant's  first
          registration  statement  after the Effective  Date. If the Shares have
          not been  registered  as of the date six (6) months from the Effective
          Date,  Miravant  shall  file a  registration  statement  covering  the
          registration of the Shares promptly upon Purchaser's written request.

     2.2  Miravant shall file a registration statement covering the registration
          of all  Securities  other than the Shares  promptly  upon  Purchaser's
          written request."

4.  Section  2.10 of the  Agreement is deleted in its entirety and is amended to
read:

          "Form S-1 and S-2. The Company  represents  and warrants that it meets
     the  requirements  for the use of Form S-1 and Form S-2 for registration of
     the sale by the Purchaser or any of its Affiliates, of the Securities,  and
     the Company shall file all reports required to be filed by the Company with
     the SEC in a timely manner so as to maintain such  eligibility  for the use
     of Form S-1 and Form S-2."

5.  Section  3.6 is amended to provide  that all notices to  Purchaser  shall be
addressed as follows:

                  Pfizer Inc.
                  235 East 42nd Street
                  New York, New York 10017
                  Telecopy:  (212) 338-1850
                  Attention:  Treasurer

                  And

                  Pfizer Inc.
                  235 East 42nd Street
                  New York, New York 10017
                  Telecopy:  (212) 808-8924

                  Attention:  Senior Vice President and General Counsel

6.  Purchaser  may assign any or all of its  rights  and  obligations  under the
Agreement, as amended by this Amendment, to any Affiliate of Purchaser.

7.  Other  than as  specifically  set forth  herein,  all  terms and  conditions
contained  in the  Agreement  shall  remain  in full  force and  effect  without
modification.

         Date: August 15, 2003             MIRAVANT MEDICAL TECHNOLOGIES


                                       By: /s/  Gary S. Kledzik
                                       ------------------------
                                                Gary S. Kledzik,
                                                Chief Executive Officer


         ACCEPTED:

         Date: August 13, 2003             PHARMACIA & UPJOHN, INC.


                                           By: /s/ Linda Libretto
                                           ----------------------
                                      Name: Linda Libretto
                                      Title: Assistant Secretary




                                  Exhibit A to

        Addendum to Registration Rights Agreement dated February 18, 1999

                          REGISTRATION RIGHTS AGREEMENT

                             DATED FEBRUARY 18, 1999