X0306 4 2019-12-16 0 0000093314 VOLITIONRX LTD VNRX 0001651671 Micallef Jacob Vincent 13215 BEE CAVE PARKWAY SUITE 125 GALLERIA OAKS B AUSTIN TX 78738 0 1 0 0 Chief Scientific Officer Option (Right to Buy) 5 2019-12-16 4 D 0 66533 0 D 2018-03-30 2023-03-30 Common Stock 70000 3467 D Option (Right to Buy) 5 2019-12-16 4 A 0 66533 0 A 2019-12-16 2023-03-30 Common Stock 66533 70000 D The reported transactions involved a cancellation and reissuance of a portion of outstanding options upon agreement of the reporting person. The "old" options were originally granted on March 30, 2017 and vested in full at 12 months from the date of grant, and were exercisable for five years from the date first exercisable. The "replacement" options are fully-vested on the date of grant and have the same expiration date and exercise price as the "old" options. /s/ Jacob Vincent Micallef 2019-12-18