Consolidated Statements of Changes in Stockholders' Equity (Deficit) - USD ($)	Common Stock	Additional Paid-In Capital	Accumulated Deficit	Total
Balance, at beginning at Dec. 31, 2016	$ 101	$ 42,616,005	$ (36,815,063)	$ 5,801,043
Balance, at beginning (in shares) at Dec. 31, 2016	1,009,210			1,358,597
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Offering of common shares, net	$ 7	541,772		$ 541,779
Offering of common shares, net (in shares)	66,593
Share-based compensation	$ 3	523,610		523,613
Share-based compensation (in shares)	28,201
Notes payable and accrued interest converted into common stock in connection with rights offering	$ 16	1,624,727		1,624,743
Notes payable and accrued interest converted into common stock in connection with rights offering (in shares)	162,474
Notes payable and accrued interest converted into common stock	$ 2	220,358		220,360
Notes payable and accrued interest converted into common stock (in shares)	22,036
Exercise of warrants	$ 3	337,497		337,500
Exercise of warrants (in shares)	33,750
Relative fair value of warrants to issued in connection with notes payable
Net loss			(5,181,535)	(5,181,535)
Balance, at end at Dec. 31, 2017	$ 132	45,863,969	(41,996,598)	$ 3,867,503
Balance, at end (in shares) at Dec. 31, 2017	1,322,264			1,322,264
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Share-based compensation	$ 4	376,496		$ 376,500
Share-based compensation (in shares)	32,555
Common stock issued under ESPP		20,326		20,326
Common stock issued under ESPP (in shares)	3,778
Relative fair value of warrants to issued in connection with notes payable		279,054		279,054
Net loss			(5,313,936)	(5,313,936)
Balance, at end at Dec. 31, 2018	$ 136	$ 46,539,845	$ (47,310,534)	$ (770,553)
Balance, at end (in shares) at Dec. 31, 2018	1,358,597			1,358,597