X0303 4 2010-02-02 0 0000930553 ISTA PHARMACEUTICALS INC ISTA 0001225755 SILVERNAIL LAUREN P 15279 ALTON PARKWAY SUITE 100 IRVINE CA 92618 0 1 0 0 CFO Common Stock 2010-02-02 4 D 0 769 3.63 D 51584 D Common Stock 2010-02-02 4 A 0 9000 0.001 A 60584 D Incentive Stock Option (right to buy) 3.63 2010-02-02 4 A 0 31826 3.63 A 2010-03-02 2020-02-02 Common Stock 31826 31826 D Non-Qualified Stock Option (right to buy) 3.63 2010-02-02 4 A 0 15174 3.63 A 2010-03-02 2020-02-02 Common Stock 15174 15174 D 25% of the original award vested. A portion of the vested shares were traded to cover income taxes. One-fourth (1/4) of the Shares subject to the Award shall vest on the first anniversary after the date of grant and one-fourth (1/4) of the Shares subject to the Award shall vest on each anniversary thereafter so that the Award shall be fully vested on the fourth anniversary after the date of grant, subject to the Optionee continuing to be a Service Provider on such dates. 1/48 of the Shares subject to the Option shall vest each month following the Vesting Commencement Date, subject to the Optionee continuing to be a Service Provider on such dates. By: /s/ Kristine Engelke, Attorney-in-Fact For: Lauren Silvernail 2010-02-04