X0202 4 2008-02-19 0 0000930553 ISTA PHARMACEUTICALS INC ISTA 0001216984 MITRO THOMAS A 15279 ALTON PARKWAY SUITE 100 IRVINE CA 92618 0 1 0 0 VP Sales & Marketing Common Stock 2008-02-19 4 F 0 348 4.56 D 23550 D 25% of the original award vested. A portion of the vested shares were traded to cover income taxes. By: /s/ Kristine Engelke, Attorney-in-Fact For: Thomas Mitro 2008-02-20