X0201 4/A 2003-09-10 2003-09-12 0 0000930553 ISTA PHARMACEUTICALS INC ISTA 0001216994 MCGRAW BENJAMIN F III 15279 ALTON PARKWAY SUITE 100 IRVINE CA 92618 1 0 0 1 Board of Director Non-Qualified Stock Option (right to buy) 6.96 2003-09-10 4 A 0 16250 0 A 2004-09-10 2013-09-10 Common Stock 16250 16250 D Shares subject to the Option shall fully vest on the first anniversary after the date of grant, provided that the Optionee shall continue to serve on the ISTA Board of Directors on such dates. By: /s/ Kristine Engelke, Attorney-in-Fact For: Benjamin McGraw 2003-09-15