X0202 4/A 2005-07-15 2005-07-19 0000930553 ISTA PHARMACEUTICALS INC ISTA 0000889232 INVESTOR AB ARSENALSGATAN 8C S-103 32 STOCKHOLM, SWEDEN V7 SWEDEN 0 0 1 0 Common Stock 2005-07-15 4 S 0 766 9.18 D 839984 I See footnotes The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by Investor Growth Capital and Investor Group on August 30, 2004. The number of Shares (defined below) sold and the number of Shares beneficially owned following the transaction were incorrectly reported in the original Form 4, thus underreporting the number of Shares sold and the number of Shares beneficially owned following the transaction by 1,020 Shares. This numerical error was carried forward through the additional transactions reported on the original Form 4 and on a subsequent Form 4 filed by the Reporting Person on July 22, 2005. These shares of the Issuer's common stock, par value $0.001 per share ("Shares"), were sold for the account of Investor Group, L.P., a limited partnership of which the Reporting Person serves as the ultimate general partner. The filing of this statement shall not be deemed an admission that the Reporting Person is the beneficial owner of any securities not held directly for its account for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise. Michael Oporto, Attorney-in-Fact 2005-09-01 Henry Gooss, Attorney-in-Fact 2005-09-01