X0202 4 2005-07-15 0000930553 ISTA PHARMACEUTICALS INC ISTA 0001237710 INVESTOR GROWTH CAPITAL LTD NATIONAL WESTMINSTER HOUSE LE TRUCHOT, ST. PETER PORT GUERNSEY, CHANNEL ISLANDS GY1 4PW 0 0 1 0 Common Stock 2005-07-15 4 S 0 426 9.12 D 1966470 D Common Stock 2005-07-15 4 S 0 840 9.15 D 1965630 D Common Stock 2005-07-15 4 S 0 70 9.16 D 1965560 D Common Stock 2005-07-15 4 S 0 3808 9.17 D 1961752 D Common Stock 2005-07-15 4 S 0 1786 9.18 D 1959966 D Common Stock 2005-07-15 4 S 0 70 9.19 D 1959896 D Common Stock 2005-07-18 4 S 0 3500 9.25 D 1956396 D Common Stock 2005-07-18 4 S 0 7000 9.20 D 1949396 D The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on August 30, 2004. Michael Oporto, Attorney-in-Fact 2005-07-19 Henry Gooss, Attorney-in-Fact 2005-07-19