February 18, 2021

U.S. Securities and Exchange Commission

100 F Street, N.E.

Washington, DC 20549

Re:    RELX PLC

Form 20-F for Fiscal Year Ended December 31, 2020

Filed February 18, 2021

File No. 001-13334

Notice of disclosure filed in Exchange Act Annual Report under Section 219 of the Iran Threat Reduction and Syria Human Rights Act of 2012 and Section 13(r) of the Exchange Act

Dear Sirs:

Pursuant to Section 219 of the Iran Threat Reduction and Syria Human Rights Act of 2012 and Section 13(r) of the Securities Exchange Act of 1934, as amended, notice is hereby provided that RELX PLC has made disclosure pursuant to those provisions in its Annual Report on Form 20-F for the year ended December 31, 2020, which was filed with the Securities and Exchange Commission on February 18, 2021.

Yours sincerely,

/s/ H Udow

Title: Chief Legal Officer and Company Secretary

RELX PLC

RELX Group plc   1-3 Strand   London, WC2N 5JR T: +44 (0)20 7166 5500       www.relx.com Registered Office 1-3 Strand, London WC2N 5JR   Registered in England number 2746616