UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549

_________________

FORM 8-K

_________________

CURRENT REPORT
PURSUANT TO SECTION 13 OR 15(d) OF THE
SECURITIES EXCHANGE ACT OF 1934

Date of Report (Date of earliest event reported):   December 20, 2005

_________________

MICROTEK MEDICAL HOLDINGS, INC.
(Exact name of registrant as specified in its charter)

_________________

Georgia	0-24866	58-1746149
(State or Other Jurisdiction       of Incorporation)	(Commission File Number)	(IRS Employer Identification No.)

13000 Deerfield Parkway, Suite 300, Alpharetta, Georgia 30004
(Address of principal executive office) (zip code)

Registrant’s telephone number, including area code:   (678) 896-4400

_________________________________________________
(Former name or former address, if changed since last report)

_________________

        Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below):

|_| Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

|_| Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

|_| Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

|_| Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

Item 1.01   Entry Into Material Definitive Agreement.

On December 20, 2005, the Board of Directors acted to accelerate the vesting of all unvested stock options previously awarded to the Company’s employees, which action was described in a press release issued by the Company dated December 21, 2005, attached hereto as Exhibit 99.1 and incorporated herein by reference. Included in the options accelerated by this action were 35,000 options held by Mark J. Alvarez, the Company’s Chief Operating Officer. None of the Company’s other executive officers or its non-employee directors were affected by this action.

Item 9.01   Financial Statements and Exhibits.

(a) Financial Statements.
N/A

(b) Pro Forma Financial Information.
N/A

(c) Exhibits.

Exhibit Number Description

99.1 Press release dated December 21, 2005

2

SIGNATURES

        Pursuant to the requirements of the Securities Exchange Act of 1934, the Company has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

	MICROTEK MEDICAL HOLDINGS, INC.
Date:    December 21, 2005	By:  /s/ Dan R. Lee
	Dan R. Lee, Chairman, President and Chief Executive Officer

3

EXHIBIT INDEX

Exhibit Number Description

99.1 Press release dated December 21, 2005

4