<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0206</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2022-02-01</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001274173</issuerCik>
        <issuerName>JANUS HENDERSON GROUP PLC</issuerName>
        <issuerTradingSymbol>JHG</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0000928265</rptOwnerCik>
            <rptOwnerName>PELTZ NELSON</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>223 SUNSET AVENUE</rptOwnerStreet1>
            <rptOwnerStreet2>SUITE 223</rptOwnerStreet2>
            <rptOwnerCity>PALM BEACH</rptOwnerCity>
            <rptOwnerState>FL</rptOwnerState>
            <rptOwnerZipCode>33480</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>28272648</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>Please see explanation below</value>
                    <footnoteId id="F1"/>
                    <footnoteId id="F2"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">Trian Fund Management, L.P. (&quot;Trian Management&quot;) serves as the management company for Trian Partners AM Holdco II, Ltd. (&quot;Trian AM Holdco II&quot;) and as such determines the investment and voting decisions of Trian AM Holdco II with respect to the shares of the Issuer held by it. Mr. Peltz is a member of Trian Fund Management GP, LLC, which is the general partner of Trian Management, and therefore is in a position to determine the investment and voting decisions made by Trian Management on behalf of Trian AM Holdco II. Accordingly, Mr. Peltz and Trian Management may be deemed to indirectly beneficially own (as that term is defined in Rule 13d-3 under the Securities Exchange Act of 1934) the shares beneficially owned by Trian AM Holdco II.</footnote>
        <footnote id="F2">(FN 1, contd.) The Reporting Persons disclaim beneficial ownership of such shares except to the extent of their respective pecuniary interests therein and this report shall not be deemed an admission that the Reporting Persons are the beneficial owner of such securities for purposes of Section 16 or for any other purpose. Mr. Peltz is a director of the Issuer.</footnote>
    </footnotes>

    <remarks>The shares which are reported on this Form 3 as being indirectly held by Mr. Peltz through his relationship with Trian AM Holdco II are also reported on the Form 3s filed by each of Ed Garden and Trian Management as being indirectly held, and represent the same shares.

Exhibit List:
Exhibit 24.1 - Power of Attorney - Nelson Peltz
Exhibit 24.2 - Power of Attorney - Trian Fund Management, L.P.</remarks>

    <ownerSignature>
        <signatureName>/s/ Daniel R. Marx, Attorney-In-Fact for Nelson Peltz</signatureName>
        <signatureDate>2022-02-09</signatureDate>
    </ownerSignature>
</ownershipDocument>
