<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:79c5c6ad-54ad-4fd9-838b-e8a846cf2e7b,g:d876c50b-760a-4cd1-a61e-152ed7a1968c-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://mckesson123.com/role/CoverPage" xlink:type="simple" xlink:href="mck-20260204.xsd#CoverPage"/>
  <link:presentationLink xlink:role="http://mckesson123.com/role/CoverPage" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_092779d2-aa64-4547-8d48-6aa4548aec9f" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntitiesTable_ad82d7dc-45b8-4824-92e2-1338b895818d" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntitiesTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_092779d2-aa64-4547-8d48-6aa4548aec9f" xlink:to="loc_dei_EntitiesTable_ad82d7dc-45b8-4824-92e2-1338b895818d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_6d67f4b2-52ee-4633-a338-68a46fa67277" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntitiesTable_ad82d7dc-45b8-4824-92e2-1338b895818d" xlink:to="loc_us-gaap_StatementClassOfStockAxis_6d67f4b2-52ee-4633-a338-68a46fa67277" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_97b12fc0-6524-4f06-b206-73eca025a6d1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfStockDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementClassOfStockAxis_6d67f4b2-52ee-4633-a338-68a46fa67277" xlink:to="loc_us-gaap_ClassOfStockDomain_97b12fc0-6524-4f06-b206-73eca025a6d1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_bac74d95-7ac3-4071-bf81-108bd2406117" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonStockMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_97b12fc0-6524-4f06-b206-73eca025a6d1" xlink:to="loc_us-gaap_CommonStockMember_bac74d95-7ac3-4071-bf81-108bd2406117" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_mck_A1.500NotesDue2025Member_dc02a3f2-924a-41ad-bb4a-63ad47e35304" xlink:href="mck-20260204.xsd#mck_A1.500NotesDue2025Member"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_97b12fc0-6524-4f06-b206-73eca025a6d1" xlink:to="loc_mck_A1.500NotesDue2025Member_dc02a3f2-924a-41ad-bb4a-63ad47e35304" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_mck_A1.625NotesDue2026Member_c07d0a2f-ab72-47d4-b127-9803d9efd73d" xlink:href="mck-20260204.xsd#mck_A1.625NotesDue2026Member"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_97b12fc0-6524-4f06-b206-73eca025a6d1" xlink:to="loc_mck_A1.625NotesDue2026Member_c07d0a2f-ab72-47d4-b127-9803d9efd73d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_mck_A3.125NotesDue2029Member_cf5862e6-abe8-4c70-83b9-3d370b9b62e6" xlink:href="mck-20260204.xsd#mck_A3.125NotesDue2029Member"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_97b12fc0-6524-4f06-b206-73eca025a6d1" xlink:to="loc_mck_A3.125NotesDue2029Member_cf5862e6-abe8-4c70-83b9-3d370b9b62e6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityInformationLineItems_2e3d7716-d182-4f38-966b-7d8525b5f251" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityInformationLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntitiesTable_ad82d7dc-45b8-4824-92e2-1338b895818d" xlink:to="loc_dei_EntityInformationLineItems_2e3d7716-d182-4f38-966b-7d8525b5f251" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_ae89ac80-35c7-4ea0-a22d-32c8317b8ee4" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentType"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_2e3d7716-d182-4f38-966b-7d8525b5f251" xlink:to="loc_dei_DocumentType_ae89ac80-35c7-4ea0-a22d-32c8317b8ee4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_3f454c28-7b85-4406-97da-036bbf61c8e7" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_2e3d7716-d182-4f38-966b-7d8525b5f251" xlink:to="loc_dei_DocumentPeriodEndDate_3f454c28-7b85-4406-97da-036bbf61c8e7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_91d17718-bee1-4a8b-9609-83af411490f0" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_2e3d7716-d182-4f38-966b-7d8525b5f251" xlink:to="loc_dei_EntityRegistrantName_91d17718-bee1-4a8b-9609-83af411490f0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_76903df0-9b15-4d36-9649-70fd45c46c75" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_2e3d7716-d182-4f38-966b-7d8525b5f251" xlink:to="loc_dei_EntityCentralIndexKey_76903df0-9b15-4d36-9649-70fd45c46c75" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_3d887b64-48d8-49ab-b2ee-067a69fc60a4" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_2e3d7716-d182-4f38-966b-7d8525b5f251" xlink:to="loc_dei_EntityFileNumber_3d887b64-48d8-49ab-b2ee-067a69fc60a4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_a2a0209e-059e-4dc4-b10b-ae3a2415a558" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_2e3d7716-d182-4f38-966b-7d8525b5f251" xlink:to="loc_dei_EntityIncorporationStateCountryCode_a2a0209e-059e-4dc4-b10b-ae3a2415a558" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_964eb349-07c1-438d-b134-67f73c668e11" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_2e3d7716-d182-4f38-966b-7d8525b5f251" xlink:to="loc_dei_EntityTaxIdentificationNumber_964eb349-07c1-438d-b134-67f73c668e11" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_d056d740-6ec2-4ddb-8db8-dc034d4d694d" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_2e3d7716-d182-4f38-966b-7d8525b5f251" xlink:to="loc_dei_EntityAddressAddressLine1_d056d740-6ec2-4ddb-8db8-dc034d4d694d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_d5fafad7-9d73-4da4-8b24-09cc2c8e5c26" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_2e3d7716-d182-4f38-966b-7d8525b5f251" xlink:to="loc_dei_EntityAddressCityOrTown_d5fafad7-9d73-4da4-8b24-09cc2c8e5c26" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_389e6743-aa7b-4058-b8c6-d60ac0877865" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_2e3d7716-d182-4f38-966b-7d8525b5f251" xlink:to="loc_dei_EntityAddressStateOrProvince_389e6743-aa7b-4058-b8c6-d60ac0877865" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_7424a3d6-f738-4020-bb79-b78dc03f5b0e" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_2e3d7716-d182-4f38-966b-7d8525b5f251" xlink:to="loc_dei_EntityAddressPostalZipCode_7424a3d6-f738-4020-bb79-b78dc03f5b0e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_848fde84-238f-4517-b72f-fc473e85cde0" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_SecurityExchangeName"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_2e3d7716-d182-4f38-966b-7d8525b5f251" xlink:to="loc_dei_SecurityExchangeName_848fde84-238f-4517-b72f-fc473e85cde0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_748275d0-48bc-42bc-979e-067aefbc7f60" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_2e3d7716-d182-4f38-966b-7d8525b5f251" xlink:to="loc_dei_CityAreaCode_748275d0-48bc-42bc-979e-067aefbc7f60" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_9106da8d-fb19-481c-9299-3f6d7e4a8c44" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_2e3d7716-d182-4f38-966b-7d8525b5f251" xlink:to="loc_dei_LocalPhoneNumber_9106da8d-fb19-481c-9299-3f6d7e4a8c44" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_89e2d825-3069-4e45-9772-c0d393422237" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_2e3d7716-d182-4f38-966b-7d8525b5f251" xlink:to="loc_dei_Security12bTitle_89e2d825-3069-4e45-9772-c0d393422237" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_833d0bb3-8168-4bc4-b29d-d85e1dda1787" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_2e3d7716-d182-4f38-966b-7d8525b5f251" xlink:to="loc_dei_TradingSymbol_833d0bb3-8168-4bc4-b29d-d85e1dda1787" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_ed2c3b4d-b945-4079-a190-72624c14c73c" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_WrittenCommunications"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_2e3d7716-d182-4f38-966b-7d8525b5f251" xlink:to="loc_dei_WrittenCommunications_ed2c3b4d-b945-4079-a190-72624c14c73c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_850b95b5-8bf3-447d-82ec-c8ef2adc40b8" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_SolicitingMaterial"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_2e3d7716-d182-4f38-966b-7d8525b5f251" xlink:to="loc_dei_SolicitingMaterial_850b95b5-8bf3-447d-82ec-c8ef2adc40b8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_9c35b911-3e0f-49cc-ac69-4690769accae" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_2e3d7716-d182-4f38-966b-7d8525b5f251" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_9c35b911-3e0f-49cc-ac69-4690769accae" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_a7c8aa58-826d-4343-a60b-b5d6bc737937" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_PreCommencementTenderOffer"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_2e3d7716-d182-4f38-966b-7d8525b5f251" xlink:to="loc_dei_PreCommencementTenderOffer_a7c8aa58-826d-4343-a60b-b5d6bc737937" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_b96162b7-98b9-4baa-aad6-b18d594a32c6" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_2e3d7716-d182-4f38-966b-7d8525b5f251" xlink:to="loc_dei_EntityEmergingGrowthCompany_b96162b7-98b9-4baa-aad6-b18d594a32c6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_8ac8c9f7-bda2-4d93-88d3-0cc3db72d504" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_2e3d7716-d182-4f38-966b-7d8525b5f251" xlink:to="loc_dei_AmendmentFlag_8ac8c9f7-bda2-4d93-88d3-0cc3db72d504" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
