X0306 4 2018-08-17 0 0000926617 VERMILLION, INC. VRML 0001623017 Palmieri Valerie Barber C/O VERMILLION, INC. 12117 BEE CAVES RD, BLDG 3 STE 100 AUSTIN TX 78738 1 1 0 0 President & CEO Common Stock, par value $0.001 per share 2018-08-17 4 P 0 97000 0.52 A 178063 D The purchase reported in column 4 is a weighted average price. The shares were purchased in multiple transactions at prices ranging from $0.5014 to $0.5335 per share. The reporting person undertakes to provide to Vermillion, any security holder of Vermillion or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each price within the range set forth in this footnote. /s/ Valerie B. Palmieri 2018-08-20