-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
 MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen
 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 AcNTPOVIqLOfAVqjpiOBawcVBlkLZFNFJST7PVrzoiS150bwThlGCD7F3xn8+KUO
 2KQeN8DbGQmfkrtToEGkHg==

<SEC-DOCUMENT>0000919574-07-004406.txt : 20070904
<SEC-HEADER>0000919574-07-004406.hdr.sgml : 20070903
<ACCEPTANCE-DATETIME>20070904132302
ACCESSION NUMBER:		0000919574-07-004406
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20070829
FILED AS OF DATE:		20070904
DATE AS OF CHANGE:		20070904

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			VERMILLION, INC.
		CENTRAL INDEX KEY:			0000926617
		STANDARD INDUSTRIAL CLASSIFICATION:	LABORATORY ANALYTICAL INSTRUMENTS [3826]
		IRS NUMBER:				330595156
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		6611 DUMBARTON CIRCLE
		CITY:			FREMONT
		STATE:			CA
		ZIP:			94555
		BUSINESS PHONE:		5105052100

	MAIL ADDRESS:	
		STREET 1:		6611 DUMBARTON CIRCLE
		CITY:			FREMONT
		STATE:			CA
		ZIP:			94555

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	CIPHERGEN BIOSYSTEMS INC
		DATE OF NAME CHANGE:	20000316

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ABIOTIC SYSTEMS
		DATE OF NAME CHANGE:	19950407

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			WIGGINS JAMES
		CENTRAL INDEX KEY:			0001310682

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-31617
		FILM NUMBER:		071096410

	BUSINESS ADDRESS:	
		BUSINESS PHONE:		(614) 224-3800

	MAIL ADDRESS:	
		STREET 1:		C/O PHRONESIS PARTNERS, L.P.
		STREET 2:		180 EAST BROAD STREET, SUITE 1704
		CITY:			COLUMBUS
		STATE:			OH
		ZIP:			43215

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			PHRONESIS PARTNERS L P
		CENTRAL INDEX KEY:			0000937074

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-31617
		FILM NUMBER:		071096411

	BUSINESS ADDRESS:	
		STREET 1:		180 EAST BROAD STREET
		STREET 2:		SUITE 1704
		CITY:			COLUMBUS
		STATE:			OH
		ZIP:			43215
		BUSINESS PHONE:		6142243800

	MAIL ADDRESS:	
		STREET 1:		180 EAST BROAD STREET
		STREET 2:		SUITE 1704
		CITY:			COLUMBUS
		STATE:			OH
		ZIP:			43215
</SEC-HEADER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>p807360_ex.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2007-08-29</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0000926617</issuerCik>
        <issuerName>VERMILLION, INC.</issuerName>
        <issuerTradingSymbol>VRML</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0000937074</rptOwnerCik>
            <rptOwnerName>PHRONESIS PARTNERS L P</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>180 EAST BROAD STREET</rptOwnerStreet1>
            <rptOwnerStreet2>SUITE 1704</rptOwnerStreet2>
            <rptOwnerCity>COLUMBUS</rptOwnerCity>
            <rptOwnerState>OH</rptOwnerState>
            <rptOwnerZipCode>43215</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001310682</rptOwnerCik>
            <rptOwnerName>WIGGINS JAMES</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O PHRONESIS PARTNERS, L.P.</rptOwnerStreet1>
            <rptOwnerStreet2>180 EAST BROAD STREET, SUITE 1704</rptOwnerStreet2>
            <rptOwnerCity>COLUMBUS</rptOwnerCity>
            <rptOwnerState>OH</rptOwnerState>
            <rptOwnerZipCode>43215</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>6665678</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                    <footnoteId id="F1"/>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>6665678</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>Footnote</value>
                    <footnoteId id="F2"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <derivativeTable>
        <derivativeHolding>
            <securityTitle>
                <value>Common Stock Warrants (right to buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>0.925</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <value>2007-08-29</value>
            </exerciseDate>
            <expirationDate>
                <value>2012-08-29</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>3895428</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                    <footnoteId id="F1"/>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
        <derivativeHolding>
            <securityTitle>
                <value>Common Stock Warrants (right to buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>0.925</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <value>2007-08-29</value>
            </exerciseDate>
            <expirationDate>
                <value>2012-08-29</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>3895428</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>Footnote</value>
                    <footnoteId id="F2"/>
                </natureOfOwnership>
            </ownershipNature>
        </derivativeHolding>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">These securities are owned by Phronesis Partners, L.P., which is a Reporting Person.</footnote>
        <footnote id="F2">These securities may be deemed to be beneficially owned by James E. Wiggins, the general partner of Phronesis Partners, L.P.
 Mr. Wiggins disclaims beneficial ownership of the reported securities except to the extent of his pecuniary interest
 therein, and this report shall not be deemed an admission that Mr. Wiggins is the beneficial owner of the securities for
 purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose.</footnote>
    </footnotes>

    <remarks>(+)  The Reporting Person disclaims beneficial ownership of the reported securities except to the extent of his pecuniary
 interest therein, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of the
 securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose.</remarks>

    <ownerSignature>
        <signatureName>Phronesis Partners, L.P.(+), By: /s/ James E. Wiggins, General Partner</signatureName>
        <signatureDate>2007-09-04</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ James E. Wiggins</signatureName>
        <signatureDate>2007-09-04</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----