Exhibit 99.1 

SCHEDULE 13G JOINT FILING AGREEMENT

The undersigned hereby agree that this Schedule 13G (as may be amended from time to time, the “Schedule 13G”) with respect to the common stock, par value $0.001 per share, of Pacific Biosciences of California, Inc. is, and any amendment thereto signed by each of the undersigned shall be, filed on behalf of each of the undersigned pursuant to and in accordance with the provisions of Rule 13d-1(k) under the Securities Exchange Act of 1934, as amended, and that all amendments to the Schedule 13G shall be filed on behalf of each of the undersigned without the necessity of filing additional joint filing agreements.  The undersigned acknowledge that each shall be responsible for the timely filing of such amendments, and for the completeness and accuracy of the information concerning it contained therein, but shall not be responsible for the completeness and accuracy of the information concerning the other, except to the extent that it knows or has reason to believe that such information is inaccurate.

Dated:  September 15, 2016

ORACLE PARTNERS, L.P.

By:  ORACLE ASSOCIATES, LLC, its general partner

By:  /s/ Larry N. Feinberg                                                              

        Larry N. Feinberg, Managing Member

ORACLE TEN FUND PARTNERS, LP

By:  ORACLE ASSOCIATES, LLC, its general partner

By:  /s/ Larry N. Feinberg                                                              

        Larry N. Feinberg, Managing Member

ORACLE INSTITUTIONAL PARTNERS, LP

By:  ORACLE ASSOCIATES, LLC, its general partner

By:  /s/ Larry N. Feinberg                                                              

        Larry N. Feinberg, Managing Member

ORACLE INVESTMENT MANAGEMENT, INC. EMPLOYEES’ RETIREMENT PLAN

 By: /s/ Aileen Wiate                                                                             Aileen Wiate, Trustee

THE FEINBERG FAMILY FOUNDATION

By:  /s/ Larry N. Feinberg                                                              

        Larry N. Feinberg, Trustee

ORACLE INVESTMENT MANAGEMENT, INC.

By:  /s/ Larry N. Feinberg                                                              

        Larry N. Feinberg, President

ORACLE ASSOCIATES, LLC

By:  /s/ Larry N. Feinberg                                                              

        Larry N. Feinberg, Manager Member

/s/ Larry N. Feinberg                                                                       

Larry N. Feinberg, individually