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Note 12 - Related Party Transactions (Details Textual) - USD ($)
1 Months Ended 3 Months Ended 9 Months Ended 12 Months Ended
Aug. 31, 2016
Sep. 30, 2019
Sep. 30, 2018
Sep. 30, 2019
Sep. 30, 2018
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Aug. 19, 2016
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross       254,785   1,698,452      
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price, Ending Balance   $ 18.90   $ 18.90   $ 2.80 $ 2.96    
Share-based Payment Arrangement, Noncash Expense, Total       $ 2,142,000 $ 2,083,000 $ 2,774,000 $ 2,707,000 $ 942,000  
Chairman and Chief Executive Officer of OPKO [Member]                  
Related Party, Ownership Percentage 5.00%               5.00%
Chairman and Chief Executive Officer of OPKO [Member] | OPKO [Member]                  
Share-based Payment Arrangement, Noncash Expense, Total   $ 116,000 $ 59,000 $ 160,000 $ 121,000        
OPKO [Member] | Consulting Services [Member]                  
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross 418,977                
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period 4 years                
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price, Ending Balance $ 1.80                
Consulting Agreement, Term 4 years                
Consulting Agreement, Term, Length of Automatic Renewal Periods 1 year                
Share-based Payment Arrangement, Noncash Expense, Total           $ 142,000 $ 480,000