Note 14 - Share-based Compensation (Tables)

12 Months Ended

Dec. 31, 2016

Notes Tables

Schedule of Share-based Compensation, Expense [Table Text Block]

	Years ended December 31,
	2016		2015
Cost of goods sold	$	14	$	4
Research and development		127		29
Selling, general and administrative		801		250
Share-based compensation expense	$	942	$	283

Schedule of Share-based Compensation, Stock Options, Activity [Table Text Block]

	Options outstanding
						Weighted
				Weighted		average
				average		remaining		Aggregate
	Number of			exercise		contractual		intrinsic
	shares			price		term (years)		value
								(In thousands)
Balance, December 31, 2015		13,788,475			0.15		6.6
Options assumed in the Merger		80,000			0.22
Stock options granted		32,177,804			0.15
Stock options exercised		(161,521	)		0.14
Stock options cancelled		(3,981,030	)		0.15
Balance, December 31, 2016		41,903,728			0.15		8.7	$	39,046
Exercisable, December 31, 2016		9,306,443			0.14		5.7	$	8,731
Vested and expected to vest, December 31, 2016		40,273,850			0.15		8.6	$	37,530

Non-employee Stock Options [Member]

Notes Tables

Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]

	2016			2015
Risk-free interest rate	1.60	-	2.42%	1.26	-	2.30%
Volatility	89	-	91%	71	-	95%
Dividend yield	None			None
Expected term (in years)	9.6	-	9.9	8.5	-	9.7

Employee Stock Option [Member]

Notes Tables

Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]

	2016
Risk-free interest rate	1.28	-	1.58%
Volatility		88%
Dividend yield	None
Expected term (in years)		6.25