The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| Agios Pharmaceuticals Inc. | COM | 00847X104 | 132,711 | 2,878,134 | SH | DFND | 3 | 2,878,134 | 0 | 0 | |
| Akcea Therapeutics, Inc. | COM | 00972L107 | 71,928 | 2,386,471 | SH | DFND | 3 | 2,386,471 | 0 | 0 | |
| Alder Biopharmaceuticals Inc. | COM | 014339105 | 28,352 | 2,766,008 | SH | DFND | 3 | 2,766,008 | 0 | 0 | |
| Alexion Pharmaceuticals, Inc. | COM | 015351109 | 127,973 | 1,314,428 | SH | DFND | 2 | 1,314,428 | 0 | 0 | |
| Alnylam Pharmaceuticals, Inc. | COM | 02043Q107 | 114,570 | 1,571,389 | SH | DFND | 3 | 1,571,389 | 0 | 0 | |
| Argenx SE | SPONSORED ADR | 04016X101 | 84,997 | 884,739 | SH | DFND | 3 | 884,739 | 0 | 0 | |
| Audentes Therapeutics, Inc. | COM | 05070R104 | 16,404 | 769,404 | SH | DFND | 3 | 769,404 | 0 | 0 | |
| Celgene Corp | COM | 151020104 | 147,655 | 2,303,875 | SH | DFND | 2 | 2,303,875 | 0 | 0 | |
| Cidara Therapeutics, Inc. | COM | 171757107 | 5,394 | 2,295,272 | SH | DFND | 3 | 2,295,272 | 0 | 0 | |
| Esperion Therapeutics, Inc. | COM | 29664W105 | 156,076 | 3,392,964 | SH | DFND | 3 | 3,392,964 | 0 | 0 | |
| Exelixis, Inc. | COM | 30161Q104 | 55,764 | 2,835,000 | SH | DFND | 3 | 2,835,000 | 0 | 0 | |
| G1 Therapeutics, Inc. | COM | 3621LQ109 | 12,867 | 671,925 | SH | DFND | 3 | 671,925 | 0 | 0 | |
| Gilead Sciences Inc. | COM | 375558103 | 83,329 | 1,332,204 | SH | DFND | 1 | 1,332,204 | 0 | 0 | |
| Halozyme Therapeutics Inc. | COM | 40637H109 | 121,763 | 8,322,860 | SH | DFND | 3 | 8,322,860 | 0 | 0 | |
| Incyte Corp. | COM | 45337C102 | 242,171 | 3,808,322 | SH | DFND | 3 | 3,808,322 | 0 | 0 | |
| Intercept Pharmaceuticals, Inc. | COM | 45845P108 | 58,027 | 575,719 | SH | DFND | 3 | 575,719 | 0 | 0 | |
| Intra-Cellular Therapies, Inc. | COM | 46116X101 | 25,058 | 2,200,000 | SH | DFND | 3 | 2,200,000 | 0 | 0 | |
| Ionis Pharmaceuticals Inc. | COM | 462222100 | 472,557 | 8,741,334 | SH | DFND | 3 | 8,741,334 | 0 | 0 | |
| Kezar Life Sciences, Inc. | COM | 49372L100 | 19,315 | 818,432 | SH | DFND | 4 | 818,432 | 0 | 0 | |
| MacroGenics Inc. | COM | 556099109 | 41,698 | 3,283,272 | SH | DFND | 3 | 3,283,272 | 0 | 0 | |
| Moderna, Inc. | COM | 60770K107 | 73,077 | 4,785,681 | SH | DFND | 4 | 4,785,681 | 0 | 0 | |
| Myokardia Inc. | COM | 62857M105 | 42,863 | 877,266 | SH | DFND | 3 | 877,266 | 0 | 0 | |
| Myovant Sciences Ltd. | COM | G637AM102 | 59,041 | 3,597,882 | SH | DFND | 3 | 3,597,882 | 0 | 0 | |
| Nektar Therapeutics | COM | 640268108 | 45,393 | 1,380,975 | SH | DFND | 3 | 1,380,975 | 0 | 0 | |
| Neurocrine Biosciences Inc. | COM | 64125C109 | 238,730 | 3,343,090 | SH | DFND | 3 | 3,343,090 | 0 | 0 | |
| Novavax Inc. | COM | 670002104 | 15,327 | 8,330,000 | SH | DFND | 3 | 8,330,000 | 0 | 0 | |
| Radius Health, Inc. | COM NEW | 750469207 | 110,652 | 6,710,276 | SH | DFND | 4 | 6,710,276 | 0 | 0 | |
| Regeneron Pharmaceuticals Inc. | COM | 75886F107 | 25,456 | 68,156 | SH | DFND | 2 | 68,156 | 0 | 0 | |
| Sage Therapeutics, Inc. | COM | 78667J108 | 131,733 | 1,375,229 | SH | DFND | 3 | 1,375,229 | 0 | 0 | |
| Sangamo Therapeutics, Inc. | COM | 800677106 | 15,498 | 1,350,000 | SH | DFND | 3 | 1,350,000 | 0 | 0 | |
| Scholar Rock Holding Corp | COM | 80706P103 | 29,401 | 1,279,978 | SH | DFND | 3 | 1,279,978 | 0 | 0 | |
| Vertex Pharmaceuticals Inc. | COM | 92532F100 | 227,096 | 1,370,445 | SH | DFND | 3 | 1,370,445 | 0 | 0 | |
| Voyager Therapeutics, Inc. | COM | 92915B106 | 26,939 | 2,865,841 | SH | DFND | 3 | 2,865,841 | 0 | 0 | |
| Wave Life Sciences Ltd. | SHS | Y95308105 | 61,589 | 1,465,002 | SH | DFND | 3 | 1,465,002 | 0 | 0 | |