The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| Achillion Pharmaceuticals Inc. | COM | 00448Q201 | 5,872 | 1,279,340 | SH | DFND | 3 | 1,279,340 | 0 | 0 | |
| Agios Pharmaceuticals Inc. | COM | 00847X104 | 147,637 | 2,869,528 | SH | DFND | 3 | 2,869,528 | 0 | 0 | |
| Alder Biopharmaceuticals Inc. | COM | 014339105 | 22,225 | 1,941,008 | SH | DFND | 3 | 1,941,008 | 0 | 0 | |
| Alexion Pharmaceuticals Inc. | COM | 015351109 | 164,793 | 1,354,428 | SH | DFND | 2 | 1,354,428 | 0 | 0 | |
| Alnylam Pharmaceuticals Inc. | COM | 02043Q107 | 97,414 | 1,221,338 | SH | DFND | 3 | 1,221,338 | 0 | 0 | |
| AveXis, Inc. | COM | 05366U100 | 33,094 | 402,800 | SH | DFND | 3 | 402,800 | 0 | 0 | |
| Celgene Corp | COM | 151020104 | 421,986 | 3,249,298 | SH | DFND | 2 | 3,249,298 | 0 | 0 | |
| Cidara Therapeutics Inc. | COM | 171757107 | 8,269 | 1,102,578 | SH | DFND | 3 | 1,102,578 | 0 | 0 | |
| Esperion Therapeutics Inc. | COM | 29664W105 | 70,047 | 1,513,542 | SH | DFND | 3 | 1,513,542 | 0 | 0 | |
| Five Prime Therapeutics Inc. | COM | 33830X104 | 23,411 | 777,500 | SH | DFND | 3 | 777,500 | 0 | 0 | |
| Gilead Sciences Inc. | COM | 375558103 | 196,386 | 2,774,596 | SH | DFND | 1 | 2,774,596 | 0 | 0 | |
| Halozyme Therapeutics Inc. | COM | 40637H109 | 105,961 | 8,265,304 | SH | DFND | 3 | 8,265,304 | 0 | 0 | |
| Incyte Corp. | COM | 45337C102 | 442,551 | 3,514,822 | SH | DFND | 3 | 3,514,822 | 0 | 0 | |
| Intercept Pharmaceuticals Inc. | COM | 45845P108 | 30,960 | 255,719 | SH | DFND | 3 | 255,719 | 0 | 0 | |
| Intra-Cellular Therapies Inc. | COM | 46116X101 | 26,703 | 2,150,000 | SH | DFND | 3 | 2,150,000 | 0 | 0 | |
| Ionis Pharmaceuticals Inc. | COM | 462222100 | 374,103 | 7,354,095 | SH | DFND | 3 | 7,354,095 | 0 | 0 | |
| Juno Therapeutics Inc. | COM | 48205A109 | 65,310 | 2,185,000 | SH | DFND | 3 | 2,185,000 | 0 | 0 | |
| Kite Pharma Inc. | COM | 49803L109 | 66,349 | 640,000 | SH | DFND | 3 | 640,000 | 0 | 0 | |
| MacroGenics Inc. | COM | 556099109 | 41,150 | 2,350,112 | SH | DFND | 3 | 2,350,112 | 0 | 0 | |
| Myovant Sciences Ltd. | COM | G637AM102 | 38,811 | 3,317,171 | SH | DFND | 3 | 3,317,171 | 0 | 0 | |
| Neurocrine Biosciences Inc. | COM | 64125C109 | 158,541 | 3,446,552 | SH | DFND | 3 | 3,446,552 | 0 | 0 | |
| Novavax Inc. | COM | 670002104 | 9,580 | 8,330,000 | SH | DFND | 3 | 8,330,000 | 0 | 0 | |
| Prothena Corp. PLC | COM | G72800108 | 18,942 | 350,000 | SH | DFND | 3 | 350,000 | 0 | 0 | |
| Radius Health Inc. | COM | 750469207 | 227,905 | 5,038,799 | SH | DFND | 4 | 5,038,799 | 0 | 0 | |
| Regeneron Pharmaceuticals Inc. | COM | 75886F107 | 88,405 | 180,000 | SH | DFND | 2 | 180,000 | 0 | 0 | |
| Sage Therapeutics Inc. | COM | 78667J108 | 72,268 | 907,439 | SH | DFND | 3 | 907,439 | 0 | 0 | |
| Tesaro Inc. | COM | 881569107 | 122,796 | 877,990 | SH | DFND | 3 | 877,990 | 0 | 0 | |
| Vertex Pharmaceuticals Inc. | COM | 92532F100 | 190,141 | 1,475,445 | SH | DFND | 3 | 1,475,445 | 0 | 0 | |