The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| Achillion Pharmaceuticals Inc. | COM | 00448Q201 | 11,335 | 1,279,340 | SH | DFND | 3 | 1,279,340 | 0 | 0 | |
| Agios Pharmaceuticals Inc. | COM | 00847X104 | 221,160 | 1,989,921 | SH | DFND | 3 | 1,989,921 | 0 | 0 | |
| Alder Biopharmaceuticals | COM | 014339105 | 61,188 | 1,155,150 | SH | DFND | 3 | 1,155,150 | 0 | 0 | |
| Alexion Pharmaceuticals Inc. | COM | 015351109 | 140,536 | 777,428 | SH | DFND | 2 | 777,428 | 0 | 0 | |
| Alnylam Pharmaceuticals Inc. | COM | 02043Q107 | 115,734 | 965,499 | SH | DFND | 3 | 965,499 | 0 | 0 | |
| Celgene Corp. | COM | 151020104 | 412,514 | 3,564,298 | SH | DFND | 2 | 3,564,298 | 0 | 0 | |
| Cempra Inc. | COM | 15130J109 | 60,711 | 1,766,900 | SH | DFND | 3 | 1,766,900 | 0 | 0 | |
| Clovis Oncology Inc. | COM | 189464100 | 54,326 | 618,188 | SH | DFND | 3 | 618,188 | 0 | 0 | |
| Gilead Sciences Inc. | COM | 375558103 | 317,942 | 2,715,596 | SH | DFND | 1 | 2,715,596 | 0 | 0 | |
| Halozyme Therapeutics Inc. | COM | 40637H109 | 137,222 | 6,077,168 | SH | DFND | 3 | 6,077,168 | 0 | 0 | |
| Incyte Corp. | COM | 45337C102 | 389,788 | 3,740,406 | SH | DFND | 3 | 3,740,406 | 0 | 0 | |
| Infinity Pharmaceuticals Inc. | COM | 45665G303 | 29,573 | 2,700,737 | SH | DFND | 3 | 2,700,737 | 0 | 0 | |
| Intercept Pharmaceuticals | COM | 45845P108 | 43,622 | 180,719 | SH | DFND | 3 | 180,719 | 0 | 0 | |
| Isis Pharmaceuticals Inc. | COM | 464330109 | 341,238 | 5,929,426 | SH | DFND | 3 | 5,929,426 | 0 | 0 | |
| Juno Therapeutics, Inc. | COM | 48205A109 | 23,999 | 450,000 | SH | DFND | 3 | 450,000 | 0 | 0 | |
| Kite Pharma, Inc. | COM | 49803L109 | 21,340 | 350,000 | SH | DFND | 3 | 350,000 | 0 | 0 | |
| Medivation Inc. | COM | 58501N101 | 147,381 | 1,290,556 | SH | DFND | 3 | 1,290,556 | 0 | 0 | |
| Neurocrine Biosciences Inc. | COM | 64125C109 | 153,861 | 3,221,552 | SH | DFND | 3 | 3,221,552 | 0 | 0 | |
| Novavax Inc. | COM | 670002104 | 91,125 | 8,180,000 | SH | DFND | 3 | 8,180,000 | 0 | 0 | |
| PTC Therapeutics Inc. | COM | 69366J200 | 60,303 | 1,252,912 | SH | DFND | 3 | 1,252,912 | 0 | 0 | |
| Puma Biotechnology Inc. | COM | 74587V107 | 60,942 | 521,991 | SH | DFND | 3 | 521,991 | 0 | 0 | |
| Radius Health Inc. | COM | 750469207 | 265,529 | 3,922,140 | SH | DFND | 4 | 3,922,140 | 0 | 0 | |
| Receptos Inc. | COM | 756207106 | 126,435 | 665,272 | SH | DFND | 3 | 665,272 | 0 | 0 | |
| Regeneron Pharmaceuticals Inc. | COM | 75886F107 | 101,006 | 198,000 | SH | DFND | 2 | 198,000 | 0 | 0 | |
| Tesaro Inc. | COM | 881569107 | 53,180 | 904,582 | SH | DFND | 3 | 904,582 | 0 | 0 | |
| Tetraphase Pharmaceuticals Inc. | COM | 88165N105 | 71,497 | 1,507,114 | SH | DFND | 3 | 1,507,114 | 0 | 0 | |
| Theravance Biopharma Inc. | COM | G8807B106 | 4,677 | 359,190 | SH | DFND | 3 | 359,190 | 0 | 0 | |
| Theravance Inc. | COM | 88338T104 | 5,992 | 331,594 | SH | DFND | 3 | 331,594 | 0 | 0 | |
| Vertex Pharmaceuticals Inc. | COM | 92532F100 | 164,777 | 1,334,445 | SH | DFND | 3 | 1,334,445 | 0 | 0 | |