The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| Achillion Pharmaceuticals Inc. | COM | 00448Q201 | 12,614 | 1,279,340 | SH | DFND | 3 | 1,279,340 | 0 | 0 | |
| Agios Pharmaceuticals Inc. | COM | 00847X104 | 174,448 | 1,849,921 | SH | DFND | 3 | 1,849,921 | 0 | 0 | |
| Alexion Pharmaceuticals Inc. | COM | 015351109 | 116,532 | 672,428 | SH | DFND | 2 | 672,428 | 0 | 0 | |
| Alnylam Pharmaceuticals Inc. | COM | 02043Q107 | 87,243 | 835,499 | SH | DFND | 3 | 835,499 | 0 | 0 | |
| Celgene Corp. | COM | 151020104 | 409,739 | 3,554,298 | SH | DFND | 2 | 3,554,298 | 0 | 0 | |
| Cempra Inc. | COM | 15130J109 | 41,961 | 1,223,000 | SH | DFND | 3 | 1,223,000 | 0 | 0 | |
| Clovis Oncology Inc. | COM | 189464100 | 45,888 | 618,188 | SH | DFND | 3 | 618,188 | 0 | 0 | |
| Gilead Sciences Inc. | COM | 375558103 | 281,201 | 2,865,596 | SH | DFND | 1 | 2,865,596 | 0 | 0 | |
| Halozyme Therapeutics Inc. | COM | 40637H109 | 91,726 | 6,423,370 | SH | DFND | 3 | 6,423,370 | 0 | 0 | |
| ImmunoGen Inc. | COM | 45253H101 | 25,425 | 2,840,816 | SH | DFND | 3 | 2,840,816 | 0 | 0 | |
| Incyte Corp. | COM | 45337C102 | 347,563 | 3,791,867 | SH | DFND | 3 | 3,791,867 | 0 | 0 | |
| Infinity Pharmaceuticals Inc. | COM | 45665G303 | 36,638 | 2,620,737 | SH | DFND | 3 | 2,620,737 | 0 | 0 | |
| Intercept Pharmaceuticals | COM | 45845P108 | 43,713 | 155,000 | SH | DFND | 3 | 155,000 | 0 | 0 | |
| Isis Pharmaceuticals Inc. | COM | 464330109 | 364,793 | 5,729,426 | SH | DFND | 3 | 5,729,426 | 0 | 0 | |
| Medivation Inc. | COM | 58501N101 | 164,526 | 1,274,706 | SH | DFND | 3 | 1,274,706 | 0 | 0 | |
| Neurocrine Biosciences Inc. | COM | 64125C109 | 127,134 | 3,201,552 | SH | DFND | 3 | 3,201,552 | 0 | 0 | |
| Novavax Inc. | COM | 670002104 | 69,882 | 8,450,000 | SH | DFND | 3 | 8,450,000 | 0 | 0 | |
| PTC Therapeutics Inc. | COM | 69366J200 | 71,676 | 1,177,912 | SH | DFND | 3 | 1,177,912 | 0 | 0 | |
| Puma Biotechnology Inc. | COM | 74587V107 | 123,247 | 521,991 | SH | DFND | 3 | 521,991 | 0 | 0 | |
| Radius Health Inc. | COM | 750469207 | 153,203 | 3,722,140 | SH | DFND | 4 | 3,722,140 | 0 | 0 | |
| Receptos Inc. | COM | 756207106 | 104,750 | 635,272 | SH | DFND | 3 | 635,272 | 0 | 0 | |
| Regeneron Pharmaceuticals Inc. | COM | 75886F107 | 89,393 | 198,000 | SH | DFND | 2 | 198,000 | 0 | 0 | |
| Synageva BioPharma Corp. | COM | 87159A103 | 100,015 | 1,025,476 | SH | DFND | 3 | 1,025,476 | 0 | 0 | |
| Tesaro Inc. | COM | 881569107 | 49,053 | 854,582 | SH | DFND | 3 | 854,582 | 0 | 0 | |
| Tetraphase Pharmaceuticals Inc. | COM | 88165N105 | 54,121 | 1,477,114 | SH | DFND | 3 | 1,477,114 | 0 | 0 | |
| Theravance Inc. | COM | 88338T104 | 13,073 | 831,594 | SH | DFND | 3 | 831,594 | 0 | 0 | |
| Vertex Pharmaceuticals Inc. | COM | 92532F100 | 157,424 | 1,334,445 | SH | DFND | 3 | 1,334,445 | 0 | 0 | |