The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| Achillion Pharmaceuticals Inc. | COM | 00448Q201 | 12,768 | 1,279,340 | SH | DFND | 3 | 1,279,340 | 0 | 0 | |
| Agios Pharmaceuticals Inc. | COM | 00847X104 | 115,983 | 1,890,521 | SH | DFND | 3 | 1,890,521 | 0 | 0 | |
| Alexion Pharmaceuticals Inc. | COM | 015351109 | 120,622 | 727,428 | SH | DFND | 2 | 727,428 | 0 | 0 | |
| Alnylam Pharmaceuticals Inc. | COM | 02043Q107 | 61,019 | 781,288 | SH | DFND | 3 | 781,288 | 0 | 0 | |
| Celgene Corp. | COM | 151020104 | 368,628 | 3,889,298 | SH | DFND | 2 | 3,889,298 | 0 | 0 | |
| Clovis Oncology Inc. | COM | 189464100 | 25,319 | 558,188 | SH | DFND | 3 | 558,188 | 0 | 0 | |
| Cubist Pharmaceuticals Inc. | RIGHT 99/99/9999 | 229678123 | 105 | 876,273 | SH | DFND | 3 | 876,273 | 0 | 0 | |
| Endocyte Inc. | COM | 29269A102 | 4,156 | 683,522 | SH | DFND | 3 | 683,522 | 0 | 0 | |
| Gilead Sciences Inc. | COM | 375558103 | 297,591 | 2,795,596 | SH | DFND | 1 | 2,795,596 | 0 | 0 | |
| Halozyme Therapeutics Inc. | COM | 40637H109 | 58,518 | 6,430,532 | SH | DFND | 3 | 6,430,532 | 0 | 0 | |
| Immunogen Inc. | COM | 45253H101 | 33,526 | 3,165,816 | SH | DFND | 3 | 3,165,816 | 0 | 0 | |
| Incyte Corp. | COM | 45337C102 | 211,007 | 4,301,867 | SH | DFND | 3 | 4,301,867 | 0 | 0 | |
| Infinity Pharmaceuticals Inc. | COM | 45665G303 | 31,144 | 2,320,737 | SH | DFND | 3 | 2,320,737 | 0 | 0 | |
| Isis Pharmaceuticals | COM | 464330109 | 257,696 | 6,636,526 | SH | DFND | 3 | 6,636,526 | 0 | 0 | |
| Medivation Inc. | COM | 58501N101 | 141,355 | 1,429,706 | SH | DFND | 3 | 1,429,706 | 0 | 0 | |
| Neurocrine Biosciences Inc. | COM | 64125C109 | 48,836 | 3,116,552 | SH | DFND | 3 | 3,116,552 | 0 | 0 | |
| Novavax Inc | COM | 670002104 | 31,275 | 7,500,000 | SH | DFND | 3 | 7,500,000 | 0 | 0 | |
| Puma Biotechnology Inc. | COM | 74587V107 | 113,796 | 476,991 | SH | DFND | 3 | 476,991 | 0 | 0 | |
| Pharmacyclics Inc. | COM | 716933106 | 85,905 | 731,542 | SH | DFND | 2 | 731,542 | 0 | 0 | |
| Radius Health Inc. | COM | 750469207 | 57,646 | 2,745,040 | SH | DFND | 2,745,040 | 0 | 0 | ||
| Receptos Inc. | COM | 756207106 | 39,550 | 636,773 | SH | DFND | 3 | 636,773 | 0 | 0 | |
| Regeneron Pharmaceuticals Inc. | COM | 75886F107 | 84,001 | 233,000 | SH | DFND | 2 | 233,000 | 0 | 0 | |
| Synageva BioPharma Corp. | COM | 87159A103 | 75,209 | 1,093,476 | SH | DFND | 3 | 1,093,476 | 0 | 0 | |
| Theravance Inc. | COM | 88338T104 | 12,702 | 743,244 | SH | DFND | 3 | 743,244 | 0 | 0 | |
| Tesaro Inc. | COM | 881569107 | 18,967 | 704,582 | SH | DFND | 3 | 704,582 | 0 | 0 | |
| Vertex Pharmaceuticals Inc. | COM | 92532F100 | 152,118 | 1,354,445 | SH | DFND | 3 | 1,354,445 | 0 | 0 | |