The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ADICET BIO, INC. | COM | 007002108 | 7,501 | 728,944 | SH | DFND | 1 | 0 | 728,944 | 0 | |
| ALDEYRA THERAPEUTICS, INC. | COM | 01438T106 | 4,473 | 394,834 | SH | DFND | 1 | 0 | 394,834 | 0 | |
| ARROWHEAD PHARMACEUTICALS | COM | 04280A100 | 270,065 | 3,260,869 | SH | DFND | 1 | 0 | 3,260,869 | 0 | |
| BIOMX INC. | COM | 09090D103 | 11,648 | 2,133,402 | SH | DFND | 1 | 0 | 2,133,402 | 0 | |
| CASTLIGHT HEALTH INC. | CL B | 14862Q100 | 2,134 | 811,295 | SH | DFND | 1 | 0 | 811,295 | 0 | |
| CATALYST BIOSCIENCES, INC. | COM | 14888D208 | 290 | 66,951 | SH | DFND | 1 | 0 | 66,951 | 0 | |
| CVRX, INC. | COM | 126638105 | 97,876 | 3,495,575 | SH | DFND | 1 | 0 | 3,495,575 | 0 | |
| FATE THERAPEUTICS, INC. | COM | 31189P102 | 293,269 | 3,379,064 | SH | DFND | 1 | 0 | 3,379,064 | 0 | |
| FUSION PHARMACEUTICALS INC. | COM | 36118A100 | 29,658 | 3,670,516 | SH | DFND | 1 | 0 | 3,670,516 | 0 | |
| GRAYBUG VISION, INC. | COM SHS | 38942Q103 | 269 | 49,547 | SH | DFND | 1 | 0 | 49,547 | 0 | |
| LEGEND BIOTECH CORPORATION | SPONSORED ADS | 52490G102 | 66,878 | 1,629,173 | SH | DFND | 1 | 0 | 1,629,173 | 0 | |
| MEIRAGTX HOLDINGS PLC | COM | G59665102 | 44,928 | 2,898,550 | SH | DFND | 1 | 0 | 2,898,550 | 0 | |
| NEUROPACE, INC. | COM | 641288105 | 1,319 | 55,435 | SH | DFND | 1 | 0 | 55,435 | 0 | |
| PHASEBIO PHARMACEUTICALS, INC. | COM | 717224109 | 5,978 | 1,607,044 | SH | DFND | 1 | 0 | 1,607,044 | 0 | |
| THERAPEUTICS ACQUISITION COR | COM CL A | 88339T103 | 10,274 | 1,000,000 | SH | DFND | 1 | 0 | 1,000,000 | 0 | |
| PROTAGONIST THERAPEUTICS INC. | COM | 74366E102 | 109,919 | 2,449,183 | SH | DFND | 1 | 0 | 2,449,183 | 0 | |
| PULMONX CORPORATION | COM | 745848101 | 249 | 5,639 | SH | DFND | 1 | 0 | 5,639 | 0 | |
| SENSEONICS HOLDINGS, INC. | COM | 81727U105 | 210 | 54,621 | SH | DFND | 1 | 0 | 54,621 | 0 | |
| TRACON PHARMACEUTICALS, INC. | COM | 89237H209 | 545 | 84,003 | SH | DFND | 1 | 0 | 84,003 | 0 | |
| VOR BIOPHARMA, INC. | COM | 929033108 | 20,042 | 1,074,658 | SH | DFND | 1 | 0 | 1,074,658 | 0 | |
| ZYMERGEN INC. | COM | 98985X100 | 662 | 16,553 | SH | DFND | 1 | 0 | 16,553 | 0 | |