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(6) Income Taxes (Details 2) (USD $)
12 Months Ended
Dec. 31, 2012
Dec. 31, 2011
Dec. 31, 2010
Income Taxes Tables      
Tax at Federal statutory rate $ (4,969,270) $ (7,755,983) $ (6,230,576)
Increase (reduction) in income taxes resulting from:      
State and local taxes (3,130) (59) (131,563)
Non-deductible expenses 50,070 (25,071) (36,423)
Settlement costs (553,700) 2,625,000 0
Shared-based payment compensation 0 0 38,042
Net effect of foreign operations 259,592 530,630 619,953
Research and development credit 0 0 (515,324)
Uncertain tax positions 140,625 118,351 28,206
Change in valuation allowance 5,862,220 5,715,464 23,538,534
Income tax reconciliation $ 786,407 $ 1,208,332 $ 17,573,975