NT 10-K

                            UNITED STATES
                  SECURITIES AND EXCHANGE COMMISSION
                         Washington, DC 20549

                             FORM 12b-25           SEC File Number: 0-24930

                                                   CUSIP Number: 12642Q 10 1

                     NOTIFICATION OF LATE FILING

(Check One):  [x] Form 10-K  Form 20-F Form 11-K Form 10-Q Form 10-D Form  N-SAR
                  Form N-CSR

For Period Ended:  December 31, 2007

     Transition Report on Form 10-K
     Transition Report on Form 20-F
     Transition Report on Form 11-K
     Transition Report on Form 10-Q
     Transition Report on Form N-SAR

For the Transition Period Ended:

Nothing  in this  form  shall be  construed  to imply  that the  Commission  has
verified any information contained herein.

If the notification  relates to a portion of the filing checked above,  identify
the Item(s) to which the notification relates:

PART I - REGISTRANT INFORMATION

Full Name of Registrant:

             CTD HOLDINGS, INC

Former Name if Applicable:

             N/A

Address of Principal Executive Office (Street and Number)

             27317 N.W. 78th AVENUE

City State and Zip Code

             HIGH SPRINGS FL 32643

PART II - RULES 12b-25(b) AND (c)

If the subject report could not be filed without  unreasonable effort or expense
and the registrant seeks relief pursuant to Rule 12b-25(b), the following should
be completed. (Check box if appropriate)

     (a)  The reasons  described in  reasonable  detail in Part III of this form
          could not be eliminated without unreasonable effort or expense;

     (b)  The subject annual report,  semi-annual  report,  transition report on
          Form  10-K,  Form  20-F,  11-K,  Form  N-SAR or Form  N-CSR or portion
          thereof,  will be  filed  on or  before  the  fifteenth  calendar  day
 [X]      following the prescribed due date; or the subject  quarterly report or
          transition report on Form 10-Q, or subject distribution report on Form
          10-D,  or  portion  thereof,  will be filed  on or  before  the  fifth
          calendar day following the prescribed due date; and

     (c)  The accountant's statement or other exhibit required by Rule 12b-25(c)
          has been attached if applicable.

PART III - NARRATIVE

State below in reasonable  detail the reasons why Forms 10-K,  20-F, 11-K, 10-Q,
10-D, N-SAR,  N-CSR, or the transition  report or portion thereof,  could not be
filed within the prescribed period of time.

Auditors required additional time to complete audit.

PART IV - OTHER INFORMATION

(1)  Name  and  telephone  number  of  person  to  contact  in  regard  to  this
notification:

                Bruce Brashear, Esq.               352-336-0800

(2) Have all other  periodic  reports  required under Section 13 of 15(d) of the
Securities and Exchange Act of 1934 or Section 30 of the Investment  Company Act
of 1940  during the  preceding  12 months or for such  shorter  period  that the
registrant  was  required to file such  report(s)  been filed?  If answer is no,
identify report(s). Yes

(3) Is it anticipated that any significant  change in results of operations from
the  corresponding  period for the last  fiscal  year will be  reflected  by the
earnings statements to be included in the subject report or portion thereof? No

If so, attach an explanation of the  anticipated  change,  both  narratively and
quantitatively, and, if appropriate, state the reasons why a reasonable estimate
of the results cannot be made.


Name of Registrant as Specified in Charter:   CTD HOLDINGS, INC

has  caused  this  notification  to be signed on its  behalf by the  undersigned
hereunto duly authorized.

                                                      /s/ C.E. RICK STRATTAN
Date: March 31, 2008                              By: C.E. RICK STRATTAN
                                                      President, CEO

INSTRUCTION: The form may be signed by an executive officer of the registrant or
by any other duly  authorized  representative.  The name and title of the person
signing  the form  shall  be typed or  printed  beneath  the  signature.  If the
statement is signed on behalf of the registrant by an authorized  representative
(other than an executive officer), evidence of the representative's authority to
sign on behalf of the registrant shall be filed with the form.

EX-5

BAUMANN, RAYMONDO & COMPANY, P.A.
405 N. REO STREET, SUITE 200
TAMPA, FL  33609
(813) 288-8826


March 31, 2008

Mr. Bruce Brashear
Brashear & Associates

Re:	CTD Holdings, Inc.

Dear Mr. Brashear:

Please note additional time is necessary to complete our audit of CTD Holdings
 as of December 31, 2007 and for the year then ended. Please file an
 extension to file the 10K.

The additional time is needed to complete our review process to the recent
 changes in the Form 10K .

Thank you for your assistance.


/s/ Baumann, Raymondo & Company, P.A.

BAUMANN, RAYMONDO & COMPANY, P.A.