Mail Stop 3-9

							April 13, 2005


Louis G. Lange, M.D., Ph.D.
Chief Executive Officer
CV Therapeutics, Inc.
3172 Porter Drive
Palo Alto, California 94304

Re:	CV Therapeutics, Inc.
	Post-effective Amendment No. 1 to
	Registration Statement on Form S-3
	File Number 333-118805

Dear Dr. Lange:

	This is to advise you that we have reviewed only those
portions
of the above registration statement that relate to the
identification
of selling security holders and have the following comments.

Selling Securityholders, page 48

1. We note the footnote to the Selling Securityholders table
indicating that sellers who are broker-dealers "may be" deemed to
be
underwriters.  Please revise this footnote to state that such
sellers
"are" underwriters.  Additionally, revise the Plan of Distribution
section such that it identifies the sellers who are broker-dealers
and states they are underwriters.

2. We note that in footnote 5 to the Selling Securityholders
table,
you state you "will identify additional selling securityholders,
if
any, by prospectus supplements or post-effective amendments."
Please
be advised that you may not use a prospectus supplement to add
selling securityholders to the registration statement unless the
new
seller is a transferee of a seller who was identified in the
registration statement pre-effectively.

*	*	*

	We urge all persons who are responsible for the accuracy and
adequacy of the disclosure in the filings reviewed by the staff to
be
certain that they have provided all information investors require
for
an informed decision.  Since the company and its management are in
possession of all facts relating to a company`s disclosure, they
are
responsible for the accuracy and adequacy of the disclosures they
have made.

	Notwithstanding our comments, in the event the company
requests
acceleration of the effective date of the pending registration
statement, it should furnish a letter, at the time of such
request,
acknowledging that:

* should the Commission or the staff, acting pursuant to delegated
authority, declare the filing effective, it does not foreclose the
Commission from taking any action with respect to the filing;

* the action of the Commission or the staff, acting pursuant to
delegated authority, in declaring the filing effective, does not
relieve the company from its full responsibility for the adequacy
and
accuracy of the disclosure in the filing; and

* the company may not assert this action as a defense in any
proceeding initiated by the Commission or any person under the
federal securities laws of the United States.

	In addition, please be advised that the Division of
Enforcement
has access to all information you provide to the staff of the
Division of Corporation Finance in connection with our review of
your
filing or in response to our comments on your filing.

	We will consider a written request for acceleration of the
effective date of the registration statement as a confirmation of
the
fact that those requesting acceleration are aware of their
respective
responsibilities under the Securities Act of 1933 and the
Securities
Exchange Act of 1934 as they relate to the proposed public
offering
of the securities specified in the above registration statement.
We
will act on the request and, pursuant to delegated authority,
grant
acceleration of the effective date.

	Please contact Greg Belliston at (202) 824-5219 or me at
(202)
942-1840 with any questions.

							Sincerely,



							Jeffrey P. Riedler
							Assistant Director


cc: 	William Davisson, Esq.
	Latham & Watkins LLP
	135 Commonwealth Drive
	Menlo Park, California 94025
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Louis G. Lange, M.D., Ph.D.
CV Therapeutics, Inc.
April 13, 2005
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