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Stock-Based Compensation (Shares Reserved for Future Issuance) (Details) - shares
Mar. 31, 2019
Dec. 31, 2018
Stock options outstanding 863,892 1,150,065
Employee stock purchase plan 76,472  
Warrants 26,480,505  
Total shares reserved 29,767,968  
Equity Incentive Plan 2016 [Member]    
Available for future grants under the 2016 Plan 2,347,099