Stockholders' Equity (Tables)

9 Months Ended

12 Months Ended

Sep. 30, 2013

Dec. 31, 2012

Equity [Abstract]

Summary of stock option activity

A summary of the Company’s stock option activity and related data for the nine months ended September 30, 2013 is as follows:

	Outstanding Options
	Number of Shares		Weighted-Average Exercise Price
Balance at December 31, 2012	592,230,567		$	0.0655
Granted
Forfeited/Expired	(5	)	88,740
Canceled	(592,230,471	)	0.0655
Balance at September 30, 2013	91		$	16,192

A summary of the Company’s stock option award activity as of and for the years ended December 31, 2012 and 2011 is as follows:

	Outstanding Options
	Shares Underlying Stock Options		Weighted-Average Exercise Price per Share		Weighted- Average Remaining Contractual Term (yrs)	Aggregate Intrinsic Value
Outstanding at December 31, 2010	980		$	20,370
Granted	—		$	—
Forfeited/Expired	(86	)	$	50,529
Outstanding at December 31, 2011	894		$	17,462
Granted	592,230,471		$	0.06
Forfeited/Expired	(798	)	$	12,095
Outstanding at December 31, 2012	592,230,567		$	0.0655	9.27	$	2,961,152
Vested and expected to vest at December 31, 2012	592,230,567		$	0.0655	1.17	$	2,961,152
Exercisable at December 31, 2012	14,180,719		$	0.2917	9.27	$	70,903

Fair value of each option grant on the date of grant using the Black-Scholes option-pricing model

The Company estimated the fair value of each option grant on the date of grant using the Black-Scholes option-pricing model with the following weighted-average assumptions:

	December 31,
	2012		2011
Risk-free interest rate	1.1	%	0	%
Dividend yield	0	%	0
Volatility	236	%	0	%
Expected life	6.04 years		0 years

Summary of share-based compensation expense related to share-based awards

The following table summarizes all share-based compensation expense related to stock options, restricted stock and restricted stock units by expense category (in thousands):

	Three Months Ended September 30,				Nine Months Ended September 30,
	2013		2012		2013		2012
Research and development
Stock options	$	250	$	267	$	897	$	503
Restricted stock	7		12		51		23
Restricted stock units	—		—		—		—
General and administrative
Stock options	1,892		2,384		6,854		4,527
Restricted stock	593		46		714		86
Restricted stock units	—		253		52		533
Share-based compensation expense included in operating expenses	$	2,742	$	2,962	$	8,568	$	5,672

The following table summarizes share-based compensation expense related to stock options by expense category (in thousands): 

	Three Months Ended September 30,				Nine Months Ended September 30,
	2013		2012		2013		2012
Research and development	$	250	$	267	$	897	$	503
General and administrative	1,892		2,384		6,854		4,527
Stock option share-based compensation expense included in operating expenses	$	2,142	$	2,651	$	7,751	$	5,030

Total share-based compensation expense related to share-based awards for the years ended December 31, 2012 and 2011 was comprised of the following (in thousands):

	December 31,
	2012		2011
Research and development	$	805	$	—
General and administrative	7,799		254
Share-based compensation expense included in operating expenses	$	8,604	$	254
Share-based compensation expense from:
Stock options	$	7,640	$	254
Restricted stock awards and restricted stock units	964		—
Share-based compensation expense included in operating expenses	$	8,604	$	254