X0202 4 2006-03-31 1 0000920465 LA JOLLA PHARMACEUTICAL CO LJPC 0001237524 REILLY TEDDI 6455 NANCY RIDGE DRIVE SAN DIEGO CA 92121 0 1 0 0 VP of Human Resources Common Stock 2006-03-31 5 J 0 E 164 3.06 A 5330 D Stock Option (right to buy) 2007-04-17 Common Stock 100891 100891 D Acquired pursuant to the Company?s Employee Stock Purchase Plan. Same as previously reported. Reporting only direct holdings, no transaction data is necessary. As of April 17, 2006, pursuant to the terms of the Amended and Restated Employment Agreement between the Company and the reporting person, dated February 23, 2006, all options owned by the reporting person (the "Options"), including 42,034 Options that became vested and exercisble on that date, were exercisable. The Options will expire and become unexercisable as of the close of business on April 17, 2007. /s/ Gail A. Sloan Attorney-in-fact for Theodora Reilly 2006-04-18