X0202 5 2005-12-31 0 0 0 0000920465 LA JOLLA PHARMACEUTICAL CO LJPC 0001344203 Naini Nader J 601 UNION STREET, SUITE 3200 SEATTLE WA 98101 1 0 0 0 Common Stock 4000000 I By Frazier Healthcare V, LP Warrants (right to buy) Common Stock 1000000 1000000 I By Frazier Healthcare V, LP Stock Options (right to buy) Common Stock 8000 8000 D These securities are held by Frazier Healthcare V, L.P. Mr. Naini is a managing member of FHM V, LLC (the general partner of FHM V, L.P., which is the general partner of Frazier Healthcare V, L.P.). As a managing member of FHM V, LLC, Mr. Naini shares voting and investment powers for securities held by Frazier Healthcare V. Mr. Naini and the Frazier entities disclaim beneficial ownership of all such securities except to the extent of their proportionate pecuniary interests therein. Reporting only indirect holdings, no transaction data is necessary. Reporting only direct holdings, no transaction data is necessary /s/ Gail A. Sloan Attorney-in-fact for Nader J. Naini 2006-02-13