10-K405

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                                 UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                    FORM 10-K

[X]    ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE
       ACT OF 1934

           For the fiscal year ended           DECEMBER 31, 2000

[ ]    TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES
       EXCHANGE ACT OF 1934

         For the transition period from ______________ to ______________


                         Commission file number 0-24274

                         LA JOLLA PHARMACEUTICAL COMPANY
             (Exact name of registrant as specified in its charter)

                                                    
           DELAWARE                                        33-0361285
(State or other jurisdiction of                         (I.R.S. Employer
 incorporation of organization)                        Identification No.)



                   6455 NANCY RIDGE DRIVE, SAN DIEGO, CA 92121
                    (Address of principal executive offices)

       Registrant's telephone number, including area code: (858) 452-6600

Securities registered pursuant to Section 12(b) of the Act:    None

Securities registered pursuant to Section 12(g) of the Act:    Common Stock, par
                                                               value $0.01
                                                               Warrants

       Indicate by check mark whether the registrant (1) has filed all reports
required to be filed by Section 13 or 15(d) of the Securities Exchange Act of
1934 during the preceding 12 months (or for such shorter period that the
registrant was required to file such reports), and (2) has been subject to such
filing requirements for the past 90 days.   Yes [X]   No [ ]

       Indicate by check mark if disclosure of delinquent filers pursuant to
Item 405 of Regulation S-K is not contained herein, and will not be contained,
to the best of registrant's knowledge, in definitive proxy or information
statements incorporated by reference in Part III of the Form 10-K or any
amendment to this Form 10-K.   [X]

       The aggregate market value of the voting stock held by non-affiliates of
the Registrant, computed by reference to the closing price of such stock on the
Nasdaq Stock Market on January 31, 2001, was $207,617,499. The number of shares
of the Registrant's common stock, $.01 par value, outstanding at January 31,
2001 was 29,395,087.

                       DOCUMENTS INCORPORATED BY REFERENCE

       Part III incorporates certain information by reference from the
Registrant's definitive proxy statement for its annual meeting of stockholders
to be held on May 18, 2001, which proxy statement will be filed on or about
April 10, 2001.


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                           FORWARD-LOOKING STATEMENTS

       This report includes forward-looking statements, including without
limitation those dealing with La Jolla Pharmaceutical Company's (the "Company")
drug development plans and clinical trials, and other matters described in terms
of our plans and expectations. The forward-looking statements in this report
involve risks and uncertainties, and a number of factors, both foreseen and
unforeseen, could cause actual results to differ from our current expectations.
Our analysis of clinical results of LJP 394, our drug candidate for the
treatment of systemic lupus erythematosus ("lupus"), is ongoing and future
analysis could result in a finding that LJP 394 is not effective in large
patient populations or does not provide a meaningful clinical benefit. Our blood
test to measure the binding affinity for LJP 394 is experimental and has not
been validated by independent laboratories. Our other potential drug candidates
are at earlier stages of development and involve comparable risks. Analysis of
our clinical trials could have negative or inconclusive results. Even if results
are promising, the Food and Drug Administration ("FDA") may require additional
clinical trials. Additional risk factors include the uncertainty of: obtaining
required regulatory approvals; successfully marketing products; receiving future
revenue from product sales or other sources such as collaborative relationships;
future profitability; the need for additional financing; the Company's
dependence on patents and other proprietary rights; the Company's limited
manufacturing capabilities; and the Company's lack of marketing experience.
Readers are cautioned to not place undue reliance upon forward-looking
statements, which speak only as of the date hereof, and the Company undertakes
no obligation to update forward-looking statements to reflect events or
circumstances occurring after the date hereof. Interested parties are urged to
review the risks described below under the heading "Certain Risk Factors" and
elsewhere in this report and in other reports and registration statements of the
Company filed with the Securities and Exchange Commission from time to time.


                                     PART I

ITEM 1. BUSINESS.

OVERVIEW

       La Jolla Pharmaceutical Company, which was founded in 1989, is a
biopharmaceutical company focused on the research and development of highly
specific therapeutic products for the treatment of certain life-threatening
antibody-mediated diseases. These diseases, including autoimmune conditions such
as lupus and antibody-mediated stroke, are caused by abnormal B cell production
of antibodies that attack healthy tissues. Current treatments for these
autoimmune disorders address only symptoms of the disease, or nonspecifically
suppress the normal operation of the immune system, which often results in
severe, negative side effects and hospitalization. We believe that our drug
candidates, called Toleragens(R), will treat the underlying cause of many
antibody-mediated diseases without these severe, negative side effects. Our
clinical drug candidate for the treatment of lupus is known as LJP 394, and is
currently being evaluated in a Phase III clinical trial. Our clinical drug
candidate for the treatment of antibody-mediated thrombosis, known as LJP 1082,
is currently being evaluated in toxicology studies that are required prior to
the initiation of clinical trials.


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ANTIBODY-MEDIATED DISEASES

       The immune system is the major biological defense mechanism responsible
for recognizing and fighting disease. The immune system identifies antigens,
such as bacteria, viruses and other disease-causing substances, and seeks to rid
the body of these antigens. There are two fundamental types of immune responses:
cell-mediated and antibody-mediated. Cell-mediated immunity is primarily
responsible for ridding the body of cells that have become infected.
Antibody-mediated immunity is primarily responsible for eliminating circulating
antigens. These immune responses are controlled by the activities of white blood
cells called T cells and B cells. T cells provide cell-mediated immunity and
regulate B cells. B cells produce antibodies that recognize and help to
eliminate antigens.

       Each B cell produces antibodies against a specific structure on the
antigen's surface called an epitope. The B cell is triggered to produce
antibodies when the specific epitope is recognized by and binds to the antibody
receptors on the surface of the B cell, and only when the B cell receives an
appropriate signal from a T cell. When an epitope binds to the B cell with no
corresponding T cell signal, the B cell may become "tolerized" and cease to
produce antibodies.

       A properly functioning immune system distinguishes between foreign
antigens and the body's healthy tissues. In a malfunctioning immune system,
healthy tissue may trigger an immune response that causes B cells to produce
disease-causing antibodies, resulting in antibody-mediated autoimmune disease.
For example, B cells can produce disease-causing antibodies that are associated
with the destruction of the kidneys in lupus and the wasting of muscles in
myasthenia gravis. Other antibody-mediated disorders include antibody-mediated
stroke, heart attack, deep vein thrombosis, recurrent fetal loss, as well as
organ rejection in xenotransplantation, and Rh hemolytic disease of the newborn.

       Current therapies for antibody-mediated diseases have significant
shortcomings, including severe side effects and a lack of specificity. Mild
forms of antibody-mediated diseases are generally treated with drugs that
address only the disease symptoms and fail to suppress disease progression,
because such drugs do not control the production of disease-causing antibodies.
Severe antibody-mediated diseases like lupus are treated with high levels of
corticosteroids and immunosuppressive therapy (primarily anti-cancer drugs)
which broadly suppress the normal function of the entire immune system. These
therapies can leave patients susceptible to potentially life-threatening
infections that may require hospitalization. Repeated dosing with
corticosteroids may cause other serious conditions, including diabetes,
hypertension, cataracts, osteonecrosis, and psychosis, and an increased risk of
severe infections which may limit the use of this therapy. The use of
chemotherapy may lead to acute problems, including weight loss, nausea, an
increased risk of severe infections and long-term adverse effects, including
sterility and an increased risk of malignancies.

LJPC'S TOLERANCE TECHNOLOGY(R) PROGRAM

       Our Tolerance Technology program focuses on the discovery and development
of proprietary therapeutics, called Toleragens, which target and suppress the
production of specific disease-causing antibodies without affecting the
protective functions of the immune system. We believe that our Toleragens will
be able to treat the underlying causes of antibody-mediated diseases, and that
our Tolerance Technology may be applied broadly wherever antibodies are involved
in the disease process.


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       Since the 1970s, hundreds of papers have been published describing animal
studies and a Nobel Prize was awarded for research in B cell tolerance. The
underlying science supporting our Tolerance Technology is based on these
discoveries as well as on our own patented research.

       Toleragens are composed of disease-specific epitopes and a carrier
platform, which are proprietary chemical structures that we have developed and
synthesized. To mimic the unique epitopes on an antigen's surface, we identify
and synthesize epitopes specific to particular antibody-mediated diseases and
attach or conjugate these epitopes to the carrier platform, which serves as a
vehicle for presenting the epitopes to the antibody receptors on the targeted B
cell. When the epitope binds to the antibody receptors on the B cell in the
absence of a T cell signal, the B cell may become tolerized and cease to produce
disease-causing antibodies. We believe that the Toleragen carrier platform, or a
modification thereof, can be used with epitopes specific to various diseases to
create therapeutics targeted at different antibody-mediated diseases.

       We design our Toleragens to bind selectively to disease-causing B cells
without affecting the function of disease-fighting B cells. This process
involves: (1) collecting and purifying the disease-causing antibodies from
patients with the targeted disease; (2) generating and selecting an epitope that
strongly binds to the purified antibodies; (3) modifying the epitope's structure
to maximize its binding properties (optimization), and (4) linking the optimized
epitope to the carrier platform. We believe this process enables us to create
Toleragens that will preferentially tolerize and shut down B cells that generate
antibodies with the highest binding affinity, and which are believed to be the
most harmful.

BUSINESS STRATEGY

       Our objective is to become the leading developer of highly specific
therapeutics for the treatment of life-threatening, antibody-mediated diseases
such as lupus, antibody-mediated stroke, heart attack, deep vein thrombosis,
recurrent fetal loss, as well as organ rejection in xenotransplantation,
myasthenia gravis and Rh hemolytic disease of the newborn. Our strategy includes
the following key elements:

       Complete the Clinical Development of LJP 394. Our primary near-term goal
is to complete development of LJP 394 to treat lupus. Following our analysis of
a Phase II/III clinical trial of LJP 394, and a positive meeting with the FDA in
April 2000, we initiated a Phase III clinical trial of LJP 394 in September
2000.

       Apply Tolerance Technology to Life-threatening Antibody-mediated
Diseases. We are focusing on chronic, life-threatening diseases and conditions
caused by antibodies, such as lupus, and antibody-mediated thrombosis, for which
there are no existing treatments or for which current therapeutics have
significant limitations. We intend to use our Tolerance Technology to design
therapeutics that specifically address other targeted antibody-mediated diseases
without adversely affecting normal immune system function.

       Utilize Strategic Collaborations to Develop and Commercialize Product
Candidates. We intend to seek appropriate collaborations with pharmaceutical
companies to provide support for our research programs and for the clinical
development and commercialization of other drug candidates.

       Expand Intellectual Property Leadership Position. We own 90 issued
patents and have 66 pending patent applications covering our various
technologies and drug candidates, including our Tolerance Technology, our lupus,
antibody-mediated thrombosis, and xenotransplantation


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drug candidates, and our platform and linkage technologies for our Toleragens.
We hope to broaden our position with future discoveries and additional patent
filings.


PRODUCTS UNDER DEVELOPMENT

       The Lupus Program

       Lupus is a life-threatening, antibody-mediated disease where
disease-causing antibodies damage various tissues. According to recent
statistics compiled by the Lupus Foundation of America, epidemiological studies
and other sources, the number of lupus patients in the United States is
estimated to be between 250,000 and 1,000,000, and approximately 16,000 new
cases are diagnosed each year. Approximately nine out of 10 lupus patients are
women, who usually develop the disease during their childbearing years. Lupus is
characterized by a multitude of symptoms, including chronic kidney inflammation
(which can lead to kidney failure), serious episodes of cardiac and
central-nervous-system inflammation, as well as extreme fatigue, arthritis and
rashes. Approximately 80% of all lupus patients will progress to serious
symptoms. Approximately 50% of lupus patients have kidney disease.

       Antibodies to double-stranded DNA ("dsDNA") can be detected in
approximately 90% of untreated lupus patients. These antibodies are widely
believed to cause kidney disease (nephritis), often resulting in morbidity and
mortality in lupus patients. These antibodies are also associated with episodes
of potentially life-threatening inflammation -- called "renal flares" -- that
may occur more than once per year and usually require intensive-care
hospitalization. Significant kidney destruction occurs during a renal flare.
Lupus nephritis can lead to deterioration of kidney function and to end-stage
kidney disease, requiring long-term renal dialysis or kidney transplantation to
sustain the patient's life.

       Current treatments for lupus patients with kidney disease and other
serious symptoms usually include repeated administration of corticosteroids,
often at high levels that can have toxic effects when used as a chronic
treatment regimen. Many patients with advanced disease are also treated with
immunosuppressive therapy, including anti-cancer drugs that have a general
suppressive effect on the immune system and may be carcinogenic. This
immunosuppressive treatment leaves the patient vulnerable to serious infection
and is a significant cause of morbidity and mortality.

       We have designed LJP 394 to suppress the production of antibodies to
dsDNA in lupus patients without suppressing the normal function of the immune
system. The design of LJP 394 is based upon scientific evidence of the role of
antibodies to dsDNA in lupus. Published studies of lupus patients indicate that
a rise in the level of antibodies to dsDNA may be predictive of renal flares in
lupus patients with renal involvement, and that suppressing antibodies to dsDNA
by treating with corticosteroids that non-specifically lower antibody levels
prevents relapses in a majority of patients. In a mouse model of lupus nephritis
that generates elevated levels of antibodies to dsDNA, administration of LJP 394
reduced the production of antibodies to dsDNA; reduced the number of
antibody-forming cells; reduced kidney disease; and extended the life of the
animals. We believe that our own and other studies provide evidence that
inhibiting antibodies to dsDNA may provide an effective therapy for lupus
nephritis.

       Certain studies of lupus patients indicate that antibodies to dsDNA with
the highest binding affinity are associated with the most damage to the kidneys.
We believe that our Tolerance Technology drug candidate preferentially targets
these antibodies.


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Results of Clinical Trials

       Based on our preclinical findings, we filed an Investigational New Drug
("IND") application for LJP 394 with the FDA in August 1994. In a double-blind,
placebo-controlled Phase I clinical trial conducted in December 1994, healthy
volunteers received LJP 394 and displayed no significant drug-related adverse
effects and no immune reaction to the drug.

       Our Phase II clinical trials included a single-dose trial, a repeat
escalating-dose trial, and a dose-ranging trial.

       The single-dose clinical trial evaluated the safety of a single, 100 mg
intravenous dose of LJP 394 in four female lupus patients by monitoring antibody
levels, blood chemistry, vital signs and complement (inflammation-promoting
proteins) levels for 28 days after dosing. LJP 394 was well tolerated by all
four patients, with no drug-related adverse clinical symptoms and no clinically
significant complement level changes. In addition, no clinically significant
immune complex formation (inflammation-promoting accumulation of antibodies and
antigens) was observed, indicating the absence of an adverse immune response to
LJP 394. A transient reduction in dsDNA antibody levels was also observed. These
results were presented at the American College of Rheumatology's Annual
International Conference in October 1996.

       The repeat escalating-dose clinical trial involved two female patients,
each receiving doses of 10, 10, 50, 50, 100 and 100 mg of LJP 394 at two-week
intervals. After the 10-week dosing regimen, the patients were followed for six
weeks. LJP 394 was well tolerated by both patients with no drug-related adverse
clinical symptoms, no clinically significant complement changes, and no
significant immune complex formation. Six weeks after the last dose, the
antibody levels in both patients remained suppressed below baseline levels.

       The dose-ranging trial evaluated 58 patients with mild lupus symptoms (53
females and five males). All patients were clinically stable and had dsDNA
antibody levels exceeding those generally found in healthy individuals. The
patients were organized into nine treatment groups at three dose levels (1 mg,
10 mg and 50 mg), and three frequencies (once per week, once every two weeks and
once every four weeks.) Patients were randomized to one of the nine treatment
groups so that at each dose and frequency, four to seven patients received LJP
394 and one patient received a placebo.

       Patients in the weekly treatment groups showed a dose-response
correlation between increasing doses of LJP 394 and reductions of levels of
dsDNA antibodies. In patients treated weekly with 10 mg or 50 mg doses of LJP
394, antibodies to dsDNA were reduced by statistically significant levels and
remained suppressed in certain patients for up to two months after the last
dose. In the patient group treated weekly with 50 mg, the reductions in median
levels of dsDNA antibodies were accompanied by increases in median levels of two
important inflammation-related complement proteins, C3 and C4, which normally
decrease during active lupus renal disease and increase with clinical
improvement. These study data suggest that complement levels and antibody levels
were normalizing in parallel.

       Throughout the dose-ranging trial, the drug was well tolerated with no
clinically significant dose-related adverse reactions observed. Three patients
experienced lupus renal flares, and three other patients were hospitalized as a
result of transient adverse events that the treating clinicians believed were
unrelated to the underlying disease or to LJP 394. Two of the patients


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with renal flares withdrew from the study, as did four patients who experienced
exacerbations of lupus, and one patient who experienced herpes rash. However, no
relationship was observed between the development of an adverse event and the
dose or frequency of administration of LJP 394.

       In December 1996, we initiated a double-blind, placebo-controlled
multi-center Phase II/III clinical trial of LJP 394. The purpose of the trial
was to evaluate the safety of the drug and its potential to prevent renal
flares, reduce disease severity and the need for immunosuppressive
steroids/chemotherapy drugs and improve patients' quality of life. The trial
enrolled over 200 patients and was conducted by LJPC and Abbott Laboratories in
over 50 sites in North America and Europe as part of our joint development
agreement with Abbott.

       In May 1999, an interim analysis of the Phase II/III clinical trial of
LJP 394 indicated that the trial was unlikely to reach statistical significance
for the primary endpoint, time to renal flare and it was decided to stop the
study and evaluate the data. There were no statistically significant serious
safety issues. In September 1999, Abbott and LJPC terminated the joint
development agreement for LJP 394.

       In November 1999, we announced encouraging initial results for LJP 394
from the analyses of the data from the Phase II/III clinical trial showing a
certain group of patients treated with LJP 394 had fewer renal flares and
treatment with high-dose corticosteroids and/or cyclophosphamide. These results
were based on an analysis of the trial using a new blood test developed at LJPC
that appears to predict which patients will respond to drug treatment. Developed
in 1998, the new blood test measures the strength of the binding between LJP 394
and a patient's antibodies to dsDNA. We found that it predicted which patients
in a previous Phase II dose-responsive trial responded to drug treatment as
measured by changes in antibody affinity following drug treatment.

       In May 2000, we completed the affinity analysis of more than 99% of the
North American patients' samples. The affinity analysis showed that 89% of these
patients had high-affinity antibodies to LJP 394 ("high-affinity" patients). The
high-affinity patients treated with drug experienced significantly longer time
to renal flare, the primary endpoint of the trial, (p=0.008), fewer renal flares
(p=0.008), longer time to treatments with high-dose corticosteroids and/or
cyclophosphamide (p=0.002) and fewer exposures high-dose corticosteroids and/or
cyclophosphamide (p=0.001) when compared to the placebo-treated group

       Also in the Phase II/III study, mean levels of circulating antibodies to
dsDNA in patients treated with LJP 394 were reduced by a statistically
significant amount relative to placebo during drug treatment. Levels of an
important complement protein, C3, improved when antibodies were reduced. In
lupus patients, this inflammation-related protein decreases during active renal
disease and increases with clinical improvement. The concurrent reduction of
antibodies to dsDNA and increase in C3 complement levels is biologically
consistent. As noted earlier, this effect had been observed in a previous Phase
II study of LJP 394 in 58 lupus patients.

       Results from the Phase II/III lupus study suggest two ways to improve the
clinical trial design of a Phase III trial:

       -      eliminate the "off" periods, and

       -      use doses of 100 mg per week


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       The Phase II/III trial design included periods during which patients
received no drug for approximately two months (the "off" periods) and weekly
doses of 50 mg over three months (the "on" periods). When patients were on drug,
mean levels of antibodies to dsDNA decreased. Unfortunately, mean levels of
antibodies to dsDNA increased when patients were off drug. During the first four
months, when patients were treated with 100 mg per week, there were nine renal
flares in the placebo-treated group and four in the drug-treated group.
Furthermore, for high affinity patients, during the first four months, there
were eight renal flares in the placebo-treated group and only one renal flare in
the drug-treated group (p=0.035).

       Based on these observations and following discussions with the FDA, we
initiated a Phase III clinical trial in September 2000 to demonstrate the safety
and efficacy of LJP 394 for lupus. In the trial, patients will be treated with
100 mg per week of LJP 394 or with placebo and there will be no "off" periods.

       The Phase III clinical trial is a double-blind, placebo-controlled study,
which will be, conducted at over 60 major medical centers in North America and
Europe. The Company plans to enroll approximately 300 lupus patients to evaluate
the potential of LJP 394 to prevent or delay renal flares, reduce the need for
treatment with high-dose corticosteroids and/or chemotherapy drugs, and improve
a patient's quality of life. Completion of the trial is expected in 2002.

       We believe that the blood test we developed can identify lupus patients
who are most likely to respond to LJP 394 and we will use this affinity assay to
identify the patients to be included in the efficacy analysis of the Phase III
trial. We have filed a patent application on this new blood assay.

       In September 2000, the FDA granted us orphan drug designation for LJP 394
for the treatment of lupus kidney disease. The Orphan Drug Act provides for
seven years of marketing exclusivity in the U.S. and enables the Company to
obtain research funding, tax credits for certain research expenses, and a waiver
of the application user fees.

       In October 2000, we presented additional data from the Phase II/III trial
at the 64th Meeting of American College of Rheumatology concerning the effect of
LJP 394 treatment on patients with impaired renal function. In a predefined
group of patients with poor renal function, there were more renal flares in the
patients treated with placebo than in the patients treated with LJP 394
(p=0.046). In a group of patients with poor renal function and with
high-affinity antibodies to LJP 394, there were six renal flares in patients
treated with placebo and no renal flares in patients treated with drug
(p=0.004).

       In January 2001, we announced that approximately 90% of patients enrolled
in each of three previous clinical trials had high-affinity antibodies to LJP
394, prior to drug treatment. The ratios for the trials were: 89% (186/211) in
the Phase II/III trial, 94% (29/31) in the Phase II trial completed in 1996 and
90% (54/60) in the Phase II trial completed in 1999. Patients in the Phase
II/III trial had moderate to severe disease and a history of renal flares.
Patients in the two Phase II trials had mild to moderate disease. Placebo and
drug-treated groups had similar percentages at baseline in each clinical trial.

       The clinical trial, and the development of LJP 394 in general, involve
many risks and uncertainties, and there can be no assurance that any previous
clinical results can be replicated in further clinical testing or that LJP 394
will be effective in inducing and sustaining antibody suppression; will prove to
be clinically safe or effective; will receive required regulatory approvals, or
if the FDA will require further clinical testing in addition to a Phase III
clinical trial.


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If the continued development of LJP 394 produces negative or inconclusive
results, our business and financial condition will be adversely affected and it
may be difficult or impossible for LJPC to survive.

       Antibody-Mediated Thrombosis, Including Stroke, Heart Attack, Deep Vein
Thrombosis and Recurrent Fetal Loss

       Researchers believe that antibodies called "antiphospholipid" antibodies
promote arterial and venous blood clots, which can cause a variety of recurring
and potentially life-threatening medical problems. For example, blood clots that
lodge in the brain may cause stroke and those that lodge in the legs may cause
deep vein thrombosis. There are multiple conditions associated with these
antibodies which we collectively refer to as antibody-mediated thrombosis:
antibody-mediated stroke, heart attack, deep vein thrombosis, recurrent fetal
loss, and complications following cardiovascular surgery. Our program to develop
a Toleragen to treat antibody-mediated thrombosis targets stroke, myocardial
infarction, deep vein thrombosis, recurrent fetal loss, and post-operative
complications. We estimate that there are about 2,000,000 patients in the United
States and Europe with antibody-mediated thrombosis.

       Stroke is a leading cause of death in the United States. In 1996, there
were approximately 2,000,000 stroke patients in the United States, approximately
700,000 new episodes occurred, and in 1994, approximately 150,000 people died
from stroke. This debilitating condition results from acute neurological injury
caused by the blockage or rupture of blood vessels in the brain. Many of the
blockages are caused by thromboses (blood clots), which many clinicians believe
may be caused by a number of factors including a class of antibodies called
antiphospholipid antibodies, which can be identified and measured by a clinical
laboratory assay. It is estimated that these antibodies cause about 10% of the
strokes in the United States (affecting 100,000 to 200,000 patients).
Antibody-mediated stroke is thought to occur in younger individuals and with
greater frequency than non-antibody-mediated stroke. The cost of treatment for a
survivor of a serious stroke is approximately $30,000 per year for life, to
provide hospitalization and home nursing care.

       Antibody-mediated thrombosis is also associated with recurrent fetal
loss, a syndrome of repeated miscarriage. Published clinical reports estimate
that many women with elevated antiphospholipid antibody levels experience
multiple miscarriages, delayed fetal development or premature childbirth. Recent
academic research suggests that elevated levels of these antibodies are also
found in approximately 10 to 30% of patients with other clotting disorders,
including myocardial infarction (heart attack), deep vein thrombosis and cardiac
valve lesion, as well as in approximately 30% of lupus patients. In myocardial
infarction, recent research suggests the relative risk of having a thrombotic
event or death is twice as high in people with high antiphospholipid antibodies,
and this risk is independent of other risk factors. In deep vein thrombosis,
research indicates antiphospholipid antibody-positive patients have recurring
deep vein thromboses twice as often as antiphospholipid antibody-negative
patients.

       Current treatments for antibody-mediated thrombosis involve the use of
chronic, potentially life-long anticoagulant therapy with drugs such as heparin
or warfarin to prevent the formation of blood clots. Patients must be carefully
monitored to minimize serious bleeding episodes that can occur because of the
therapy. If patients are removed from anticoagulant therapy, they are at an
increased risk of stroke or another thrombotic episode. Warfarin is not
recommended in the treatment of recurrent fetal loss because it is toxic to the
developing fetus.


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       We believe that a Toleragen to treat this antibody-mediated thrombosis
would be a major step forward in specifically targeting the cause of this
clotting disorder, thereby avoiding the side effects of current therapy.

       Our research supports the finding that specific antibodies in
antibody-mediated thrombosis enhance blood-clot formation by interfering with
the natural breakdown of a blood component -- Factor Va -- that accelerates
clotting. The true target of these clot-promoting antibodies is not, in fact,
cardiolipin, but a small region on a blood protein called b2-glycoprotein I. To
date, our scientists have shown that approximately 90% of patients studied with
antibody-mediated thrombosis have antibodies that bind to this region. The
identification of a disease target for antibody-mediated thrombosis has allowed
us to begin building new drug candidates that bind to these antibodies with high
affinity and are designed to tolerize, or shut down, the B cells that produce
them.

       We have synthesized a family of candidate antibody-mediated thrombosis
Toleragens for testing. We have also developed a mouse model of the disease,
where the animals produce antibodies to b2-glycoprotein I and develop a clotting
defect similar to that seen in patients with antibody-mediated thrombosis. In
this animal model, several candidate molecules have been shown to reduce the
production of pathogenic antibodies, a key step in the development of a drug to
treat this disorder.

       In July 2000, we nominated LJP 1082 as our clinical drug candidate for
the treatment of antibody-mediated thrombosis. Based on positive preclinical
results in mice, rats, and primates, we chose this candidate for planned
toxicology studies required for the filing of an Investigational New Drug
Application (IND). In September 2000, we presented positive preclinical results
at the 9th International Symposium on Antiphospholipid Antibodies in Tours,
France which showed LJP 1082 reduced disease-causing antibodies and the B cells
involved in antibody-mediated thrombosis in an animal model of the disease.

       Other Antibody-Mediated Diseases

       We believe our Tolerance Technology may be applicable to additional
diseases and conditions caused by the production of disease-causing antibodies,
including xenotransplantation, myasthenia gravis and Rh hemolytic disease of the
newborn.

       Xenotransplantation, the use of animals as a source of donor organs for
human transplantation, has become an area of great interest due to the worldwide
shortage of human organs available for transplantation. According to the
American Society of Transplant Physicians, approximately 100,000 patients in the
United States are on waiting lists for organ transplants. More than 5,000
patients die annually, many of who are too sick to qualify for waiting lists. A
typical organ transplant can cost more than $100,000.

       Hyperacute rejection, or the immediate destruction of the transplanted
animal organ by the recipient's antibodies, is a major barrier to
xenotransplantation. Human antibodies recognize and bind to an epitope called
alpha galactose found on the tissues of transplanted animal organs. This binding
causes massive blood clots that block the blood supply to the transplanted
organ, destroying it within minutes.

       Myasthenia gravis is a form of muscular paralysis in which neuromuscular
receptors are attacked by antibodies, which can lead to a wasting of muscles,
progressive loss of strength and


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life-threatening respiratory arrest. This disease affected an estimated 20,000
people in the United States in 1994.

       Rh hemolytic disease of the newborn is a life-threatening fetal condition
characterized by the hemolysis (destruction) of fetal red blood cells. This
condition occurs in Rh-incompatible pregnancies in which maternal antibodies to
Rh cross the placenta, bind to fetal red blood cells and cause their
destruction. Each year approximately 500,000 women in the United States have
Rh-incompatible pregnancies. We believe that a Toleragen that binds to the
appropriate maternal B cells will suppress Rh antibody production, and that once
the level of antibodies to Rh(+) red blood cells is reduced, the risk of
life-threatening hemolysis will be reduced.

COLLABORATIVE ARRANGEMENTS

       As part of our business strategy, we attempt to pursue collaborations
with pharmaceutical companies in an effort to access their research, drug
development, manufacturing, marketing and financial resources. In December 1996,
we entered into a collaborative relationship with Abbott for worldwide
development and commercialization of LJP 394. This agreement was terminated in
September 1999 following the initial analysis of the Phase II/III lupus trial,
and all rights to LJP 394 were returned to us.

       Concurrently with the formation of the collaborative relationship, Abbott
had made an initial $4.0 million license payment to LJPC and purchased 1,000,050
shares of our common stock for gross proceeds of $4.0 million. In September 1997
and October 1998, Abbott also purchased 831,152 and 1,538,402 shares of our
common stock, respectively, for gross proceeds of $4.0 million on each purchase
date. We incurred research and development costs for the development of LJP 394
of approximately $9.9 million in 1997, $8.6 million in 1998 and $4.7 million in
1999 under the collaborative agreement with Abbott.

       We intend to pursue collaborative arrangements with other pharmaceutical
companies to assist in our research programs and the clinical development and
commercialization of our drug candidates. There can be no assurance that we will
be able to negotiate arrangements with any other collaborative partners on
acceptable terms, if at all. Once a collaborative relationship is established,
there can be no assurance that the collaborative partner will continue funding
any particular program or will not pursue alternative technologies or develop
alternative drug candidates, either individually or in collaboration with
others, including our competitors, as a means for developing treatments for the
diseases we have targeted. Furthermore, competing products, either developed by
a collaborative partner or to which a collaborative partner has rights, may
result in the withdrawal of support by the collaborative partner with respect to
all or a portion of our technology.

       Failure to establish or maintain collaborative arrangements will require
us to fund our own research and development activities, resulting in accelerated
depletion of capital, and will require us to develop our own marketing
capabilities for any drug candidate that may receive regulatory approval. The
failure of any collaborative partner to continue funding any particular program
of ours, or to commercialize successfully any product, could delay or halt the
development or commercialization of any products involved in such program. As a
result, failure to establish or maintain collaborative arrangements could hurt
our business, financial condition and results of operations.


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MANUFACTURING

       We have constructed and are currently operating a pilot production
facility for the manufacture of LJP 394 that is large enough to exceed
anticipated research and clinical trial needs for LJP 394. Through internal
development programs and external collaborations, we have made several
improvements to the manufacturing process for LJP 394 that have reduced our
costs and increased capacity. We have developed proprietary synthesis and
conjugation technologies that are being used in the development of our other
Toleragen candidates. We intend to further develop these technologies in order
to increase our manufacturing efficiencies and apply our expertise to the
development and manufacture of other potential products.

       While we believe that our current production facility will provide
sufficient capacity for launch as planned, additional capacity will be required.
Following launch, we plan to increase capacity through contract manufacturing
and additional capital investments in the expansion of our facilities. The
manufacture of our potential products for clinical trials and the manufacture of
any resulting products for commercial purposes is subject to current Good
Manufacturing Practices ("cGMP"), as defined by the FDA. We have never operated
a FDA-approved manufacturing facility, and there can be no assurance that we
will obtain the necessary approvals. We have limited manufacturing experience,
and no assurance can be given that we will be able to make the transition to
commercial production successfully. We may enter into arrangements with contract
manufacturers to expand our own production capacity in order to meet
requirements for our products or to attempt to improve our manufacturing
efficiency. If we choose to contract for manufacturing services and encounter
delays or difficulties in establishing relationships with manufacturers to
produce, package and distribute finished products, clinical trials, market
introduction and subsequent sales of such products would be adversely affected.
Moreover, contract manufacturers must operate in compliance with the FDA's cGMP
requirements. Our potential dependence upon others for the manufacture of our
products may adversely affect our profit margins and our ability to develop and
deliver such products on a timely and competitive basis.

MARKETING AND SALES

       In order to commercialize any drug candidate approved by the FDA, we must
either develop a marketing and sales force or enter into marketing arrangements
with others. These arrangements may be exclusive or nonexclusive and may provide
for marketing rights worldwide or in a specific market. We currently have no
arrangements with others for the marketing of any of our drug candidates. There
can be no assurance that we will be able to enter into any marketing agreements
on favorable terms, if at all, or that any such agreements that we may enter
into will result in payments to us. Under any co-promotion or other marketing
and sales arrangements that we may enter into with other companies, any revenues
that we may receive will be dependent on the efforts of others and there can be
no assurance that such efforts will be successful. To the extent that we choose
to attempt to develop our own marketing and sales capability, we will compete
with other companies that currently have experienced and well-funded marketing
and sales operations. Furthermore, there can be no assurance that we or any
collaborative partner will be able to establish sales and distribution
capabilities without undue delays or expenditures or gain market acceptance for
any of our drug candidates.

PATENTS AND PROPRIETARY TECHNOLOGIES

       We file patent applications in the United States and in foreign
countries, as we deem appropriate, for the protection of our proprietary
technologies and drug candidates. We own 90


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issued patents and have 66 pending patent applications covering various
technologies and drug candidates, including our Tolerance Technology, our lupus
and antibody-mediated stroke drug candidates, and our linkage technologies for
our Toleragens. Our issued patents include:

       (1)    four issued United States patents, one issued Australian patent,
              one granted Portuguese patent, one granted Norwegian patent, one
              granted European patent which has been unbundled as 13 European
              national patents and one granted Canadian patent concerning our
              lupus Toleragens (expiring in 2010, 2011, 2013, 2014, 2007, 2013,
              2011, 2011 and 2011, respectively);

       (2)    three issued United States patents, two issued Australian patents,
              one granted European patent which has been unbundled as 15
              European national patents, one granted Japanese patent, one
              granted Canadian patent, one granted South Korean patent and one
              granted Irish patent concerning our Tolerance Technology (expiring
              in 2011, 2011, 2014, 2008, 2014, 2012, 2012, 2012, 2012 and 2012,
              respectively);

       (3)    four issued United States patents, three issued Australian
              patents, one granted European patent which has been unbundled as
              15 European national patents, one issued Japanese patent, one
              granted Hong Kong patent, and one granted Portuguese patent
              concerning linkage technologies for our Toleragens (expiring in
              2012, 2015, 2015, 2016, 2014, 2012, 2012, 2012, 2012, 2012 and
              2014, respectively); and

       (4)    one issued U.S. patent and one issued Australian patent concerning
              our antibody-mediated stroke drug candidates (expiring in 2016 and
              2016, respectively).

       We have received a Notice of Allowance from the Canadian Patent Office
for a patent application for our lupus Toleragens, as well as a Notice of
Allowance from the United States Patent and Trademark Office (USPTO) for a
patent application for our antibody-mediated stroke drug candidates.

COMPETITION

       The biotechnology and pharmaceutical industries are subject to rapid
technological change. Competition from domestic and foreign biotechnology
companies, large pharmaceutical companies and other institutions is intense and
expected to increase. A number of companies are pursuing the development of
pharmaceuticals in our targeted areas. These include companies that are
conducting clinical trials and preclinical studies for the treatment of lupus.

       In addition, there are many academic institutions, both public and
private, engaged in activities relating to the research and development of
therapeutics for autoimmune, inflammatory and other diseases. Most of these
companies and institutions have substantially greater facilities, resources,
research and development capabilities, regulatory compliance expertise, and
manufacturing and marketing capabilities than we do. In addition, other
technologies may in the future be the basis of competitive products. There can
be no assurance that our competitors will not develop or obtain regulatory
approval for products more rapidly than us, or develop and market technologies
and products that are more effective than those being developed by us or that
would render our technology and proposed products obsolete or noncompetitive.


                                       13
   14

       We believe that our ability to compete successfully will depend upon our
ability to attract and retain experienced scientists, develop patented or
proprietary technologies and products, obtain regulatory approvals, manufacture
and market products either alone or through third parties, and secure additional
capital resources to fund anticipated net losses for at least the next several
years. We expect that competition among products approved for marketing will be
based in large part upon product safety, efficacy, reliability, availability,
price and patent position.

GOVERNMENT REGULATION

       Our research and development activities and the future manufacturing and
marketing of any products developed by LJPC are subject to significant
regulation by numerous government authorities in the United States and other
countries. In the United States, the Federal Food, Drug and Cosmetic Act and the
Public Health Service Act govern the testing, manufacture, safety, efficacy,
labeling, storage, record keeping, approval, advertising and promotion of any
products we may develop. In addition to FDA regulations, we are subject to other
federal, state and local regulations, such as the Occupational Safety and Health
Act and the Environmental Protection Act, as well as regulations governing the
handling, use and disposal of radioactive and other hazardous materials used in
our research activities. Product development and approval within this regulatory
framework takes a number of years and involves the expenditure of substantial
resources. In addition, this regulatory framework is subject to changes that may
affect approval, delay an application or require additional expenditures.

       The steps required before a pharmaceutical compound may be marketed in
the United States include (1) preclinical laboratory and animal testing; (2)
submission to the FDA of an Investigational New Drug ("IND") application, which
must become effective before clinical trials may commence; (3) adequate and
well-controlled clinical trials to establish the safety and efficacy of the
drug; (4) submission to the FDA of a New Drug Application ("NDA"); and (5) FDA
approval of the NDA prior to any commercial sale or shipment of the drug. In
addition to obtaining FDA approval for each product, each domestic
drug-manufacturing establishment must be registered with, and approved by, the
FDA. Drug product manufacturing establishments located in California also must
be licensed by the State of California in compliance with separate regulatory
requirements.

       Preclinical testing includes laboratory evaluation of product chemistry
and animal studies to assess the safety and efficacy of the product and its
formulation. The results of preclinical testing are submitted to the FDA as part
of an IND and, unless the FDA objects, the IND will become effective 30 days
following its receipt by the FDA.

       Clinical trials involve administration of the drug to healthy volunteers
or to patients diagnosed with the condition for which the drug is being tested
under the supervision of a qualified clinical investigator. Clinical trials are
conducted in accordance with protocols that detail the objectives of the study,
the parameters to be used to monitor safety, and the efficacy criteria to be
evaluated. Each protocol is submitted to the FDA as part of the IND. Each
clinical trial is conducted under the auspices of an independent Institutional
Review Board ("IRB"). The IRB will consider, among other matters, ethical
factors, the safety of human subjects and the possible liability of the
institution.

       Clinical trials are typically conducted in three sequential phases, but
the phases may overlap. In Phase I, the initial introduction of the drug into
healthy human subjects, the drug is tested for safety (adverse effects), dosage
tolerance, metabolism, distribution, excretion and clinical pharmacology. Phase
II involves trials in a limited patient population to (1) characterize


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   15

the actions of the drug in targeted indications, (2) determine drug tolerance
and optimal dosage and (3) identify possible adverse side effects and safety
risks. When a compound is found to be effective and to have an acceptable safety
profile in Phase II clinical trials, Phase III clinical trials are undertaken to
further evaluate and confirm clinical efficacy and safety within an expanded
patient population at multiple clinical trial sites. The FDA reviews both the
clinical plans and the results of the trials and may discontinue the trials at
any time if significant safety issues arise.

       The results of preclinical testing and clinical trials are submitted to
the FDA in the form of an NDA or Product License Application for marketing
approval. The testing and approval process is likely to require substantial time
and effort and there can be no assurance that any approval will be granted on a
timely basis, if at all. The approval process is affected by a number of
factors, including the severity of the disease, the availability of alternative
treatments, and the risks and benefits demonstrated in clinical trials.

       Additional preclinical testing or clinical trials may be requested during
the FDA review period and may delay marketing approval. After FDA approval for
the initial indications, further clinical trials may be necessary to gain
approval for the use of the product for additional indications. The FDA mandates
that adverse effects be reported to the FDA and may also require post-marketing
testing to monitor for adverse effects, which can involve significant expense.

       Among the conditions for FDA approval is the requirement that the
prospective manufacturer's quality control and manufacturing procedures conform
to the FDA's cGMP requirements. Domestic manufacturing facilities are subject to
biennial FDA inspections and foreign manufacturing facilities are subject to
periodic inspections by the FDA or foreign regulatory authorities.

       We are also subject to numerous and varying foreign regulatory
requirements governing the design and conduct of clinical trials and marketing
approval for pharmaceutical products to be marketed outside of the United
States. The approval procedure varies among countries and can involve additional
testing, and the time required to obtain approval may differ from that required
to obtain FDA approval. The foreign regulatory approval process includes all of
the risks associated with obtaining FDA approval, and approval by the FDA does
not ensure approval by the health authorities of any other country.

EMPLOYEES

       We currently have 78 full-time employees (including 14 Ph.D.'s and 2
M.D.'s), 51 of whom are involved full-time in research, development and
manufacturing scale-up activities. All of our management has had prior
experience with pharmaceutical, biotechnology or medical product companies. We
believe that we have been successful in attracting skilled and experienced
scientific personnel, but competition for such personnel is intense and there
can be no assurance that we will be able to attract and retain the individuals
needed. None of our employees is covered by collective bargaining agreements and
management considers relations with our employees to be good.



                              CERTAIN RISK FACTORS

       In this section, all references to "LJPC", "we," "our," and "us," refer
to La Jolla Pharmaceutical Company, a Delaware corporation.


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   16

I.     RISK FACTORS RELATING TO LA JOLLA PHARMACEUTICAL AND THE INDUSTRY IN
       WHICH WE OPERATE.

OUR DRUG CANDIDATES MAY NOT PERFORM WELL IN CLINICAL TRIALS AND WE MAY NOT BE
PERMITTED TO CONDUCT FURTHER CLINICAL TRIALS. WITHOUT SUCCESSFUL CLINICAL
TRIALS, WE WILL NOT BE ABLE TO MARKET OR SELL ANY PRODUCTS.

       If LJP 394 is ultimately not found to be safe and effective, we would be
unable to obtain regulatory approval for its commercialization. Because LJP 394
is our only drug candidate that has advanced to clinical trials, and because
there is no guarantee that we would be able to develop an alternate drug
candidate, our inability to commercialize LJP 394 would have a severe negative
effect on our business, including revenues and profits.

       In order to sell our products that are under development, we must first
receive regulatory approval. To obtain regulatory approval, we must conduct
clinical studies demonstrating that our products are safe and effective.
Although LJP 394 appears promising, it may not be successful in future clinical
trials. Our prior clinical study of LJP 394, in collaboration with Abbott, was
halted, and the ongoing Phase III clinical study may also be delayed or halted
for various reasons, including:

       -      the product is not effective,

       -      patients experience severe side effects during treatment,

       _      patients do not enroll in the study at the rate we expect, or

       -      product supplies are not sufficient to treat the patients in the
              study.

       In addition, the FDA and foreign regulatory authorities have substantial
discretion in the approval process. The FDA and foreign regulatory authorities
may not agree that we have demonstrated that LJP 394 is safe and effective after
we complete clinical trials. Even if the results of prior clinical trials are
positive, the FDA and foreign regulatory authorities may require us to design
and conduct additional studies, which may result in significant expense and
delay. The FDA and foreign regulatory authorities may require new clinical
trials because of inconclusive results from earlier clinical trials, a possible
failure to conduct prior clinical trials in complete adherence to FDA good
clinical practice standards and similar standards of foreign regulatory
authorities and identification of new clinical trial endpoints.

OUR PRODUCTS ARE IN VARIOUS STAGES OF DEVELOPMENT AND THE TECHNOLOGY UNDERLYING
OUR PRODUCTS IS UNCERTAIN AND UNPROVEN. IF OUR PRODUCTS CANNOT BE SUCCESSFULLY
DEVELOPED, WE WILL NEVER BE ABLE TO GENERATE MEANINGFUL SALES.

       All of our product development efforts are based on unproven technologies
and therapeutic approaches that have not been widely tested or used. LJP 394 has
not been proven to be effective in humans and the technology on which it is
based has been used only in our preclinical tests and clinical trials. If our
products or technology is not effective, we will not generate meaningful sales.
Application of LJP 394's technology to antibody-mediated diseases other than
lupus is in even earlier research stages.

       LJP 394 and our other potential drug candidates require significant
additional research and development and are subject to significant risks.
Potential products that appear to be


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promising at early stages of development may nevertheless fail to reach market
or become profitable for some of the following reasons:

       -      products may be ineffective or cause harmful side effects during
              preclinical testing or clinical trials,

       -      products may fail to receive necessary regulatory approvals,

       -      products may be difficult to manufacture,

       -      products may be uneconomical to produce particularly if high
              dosages are required,

       -      products may fail to achieve market acceptance,

       -      physicians think that the products are not effective,

       -      products may be precluded from commercialization because of
              proprietary rights of third parties, and

       -      competitors may develop superior products.

       The technology underlying LJP 394 appears effective in humans. However,
no products have been developed to date that use our technology. There is no
guarantee that LJP 394 will work as intended. Furthermore, clinical trials of
LJP 394 may be viewed as a test of our entire approach to developing therapies
for antibody-mediated diseases. If the data from our clinical trials indicates
that LJP 394 is ineffective, the applicability of our technology to other
antibody-mediated diseases will be highly uncertain. Therefore, there is
significant risk that our therapeutic approaches will not prove to be
successful, and there can be no guarantee that our drug discovery technologies
will result in any commercially successful products.

OUR SUCCESS IN DEVELOPING OUR PRODUCTS AND MARKETING THEM SUCCESSFULLY DEPENDS
SIGNIFICANTLY UPON OUR ABILITY TO OBTAIN PATENT PROTECTION FOR LJP 394 AND ANY
OTHER DEVELOPED PRODUCTS. IN ADDITION, WE WILL NEED TO SUCCESSFULLY PRESERVE OUR
TRADE SECRETS AND OPERATE WITHOUT INFRINGING ON THE RIGHTS OF OTHERS.

       We will depend on patents and other unpatented intellectual property to
prevent others from profiting from products or technologies that we may have
developed, and to preserve our freedom to operate our business. We own 90 issued
patents and have 66 pending patent applications covering various technologies
and drug candidates. However, there can be no assurance that any additional
patents will be issued, or that the scope of any patent protection will be
sufficient, or that any current or future issued patent will be held valid if
subsequently challenged. There is a substantial backlog of biotechnology patent
applications at the U.S. Patent and Trademark Office that may delay the review
and issuance of any patents. The patent position of biotechnology firms like
ours generally is highly uncertain and involves complex legal and factual
questions, and no consistent policy has emerged regarding the breadth of claims
covered in biotechnology patents or protection afforded by these patents.
Presently, we have a number of patent applications pending in the United States
relating to our technology, as well as foreign counterparts to some of our U.S.
patent applications. We intend to continue to file applications as appropriate
for patents covering both our products and processes. There can be no assurance
that patents will be issued from any of these applications, or that the scope of
any issued patents will protect our technology.


                                       17
   18

       We are aware of one U.S. patent grant that contains claims covering
subject matter that may conflict with some of our key patents and patent
applications, and that may affect our ability to develop and sell our products.
Any conflict between our patents and patent applications, and patents or patent
applications of third parties, could result in a significant reduction of the
coverage of our existing patents or any future patents that may be issued. This
could have a negative effect on our ability to prevent competitors from
profiting from our products and technologies, and this could affect our future
sales. In addition, we may have to incur significant expenses in defending our
patents.

       If the U.S. Patent and Trademark Office or any foreign counterpart issues
or has issued to a competitor patents containing competitive or conflicting
claims, and if these claims are valid, there can be no guarantee that we would
be able to obtain licenses to these patents, that any licensing fees would be
reasonable, or that we would be able to develop or obtain alternative
technology. Patent applications in the United States are kept secret until a
patent is issued. As a result, we do not know if others, including competitors,
have filed patent applications for technology covered by our pending
applications, nor can we be certain that we were the first to invent or to file
patent applications for our technologies. Competitors may have patents or patent
applications pending that relate to compounds or processes that overlap or
compete with our intellectual property.

       We also rely on unpatented intellectual property such as trade secrets
and improvements, know-how, and continuing technological innovation. While we
seek to protect these rights, it is possible that:

       -      inventions relevant to our business will be developed by a person
              not bound by an LJPC invention assignment agreement,

       -      binding LJPC confidentiality agreements will be breached and we
              will not have adequate remedies for such a breach, or

       -      our trade secrets will otherwise become known or be independently
              discovered by competitors.

       We could incur substantial costs in defending suits brought against us by
others for infringement of intellectual property rights or in prosecuting suits
that we might bring against others to protect our intellectual property rights.

WE HAVE A HISTORY OF LOSSES AND MAY NOT BECOME PROFITABLE.

       We have incurred operating losses each year since our inception in 1989
and had an accumulated deficit of approximately $85.6 million as of December 31,
2000. Our losses are likely to exceed those experienced in prior years due to
the termination of a collaborative relationship with Abbott, unless we are
successful in establishing additional collaborative relationships to help
finance our research and development costs. To achieve profitability we must,
among other things, complete the development of our products, obtain all
necessary regulatory approvals and establish commercial manufacturing and
marketing capabilities. We expect to incur significant losses each year for at
least the next several years as our clinical trial, research, development and
manufacturing activities increase. The amount of losses and the time required by
us to reach sustained profitability are highly uncertain, and we do not expect
to generate revenues from the sale of products, if any, for at least several
years. We may never achieve product revenues or profitability.


                                       18
   19

WE WILL NEED ADDITIONAL FUNDS TO SUPPORT OPERATIONS AND MAY NEED TO REDUCE
OPERATIONS, SELL STOCK OR ASSETS, OR MERGE WITH ANOTHER ENTITY TO CONTINUE
OPERATIONS.

       Our operations to date have consumed substantial capital resources, and
we will continue to expend substantial and increasing amounts of capital for
research, product development, preclinical testing and clinical trials of drug
candidates, to establish commercial-scale manufacturing capabilities, and to
market potential products. We will need to raise additional funds in some way,
and if we are not able to do so we will not be able to fund our operations.

       Our future capital requirements will depend on many factors, including:

       -      continued scientific progress in our research and development
              programs and the size and complexity of these programs,

       -      the scope and results of preclinical testing and clinical trials,

       -      the time and costs involved in applying for regulatory approvals,

       -      the costs involved in preparing, filing, prosecuting, maintaining
              and enforcing patent claims,

       -      competing technological and market developments,

       -      our ability to establish and maintain collaborative research and
              development arrangements, and

       -      the cost of manufacturing scale-up and effective commercialization
              activities and arrangements.

       We expect to incur substantial and increasing losses each year for at
least the next several years as our clinical trial, research, development and
manufacturing activities increase. We expect that our existing capital resources
(including the net proceeds of approximately $33.1 raised through the sale of
5,700,000 shares of our common stock in February 2001) will be sufficient to
fund our activities, as currently planned, through 2002. However, the amounts
expended by us for various purposes may vary significantly, and it is possible
that our cash requirements will exceed current projections and that we will
therefore need additional financing sooner than currently expected. In the
future, it is possible that we will not have adequate resources to support our
business activities.

       We actively seek additional funding, including through collaborative
arrangements and public and private financings. Our choice of financing
alternatives may vary from time to time depending upon various factors,
including the market price of our securities, conditions in the financial
markets and the interest of other entities in strategic transactions with us.
There can be no guarantee that additional financing will be available on
acceptable terms, if at all, whether through collaborative arrangement, issuance
of securities, or otherwise. If adequate funds are not available, we may be
required to delay, scale back or eliminate one or more of our research and
development programs or obtain funds through arrangements with collaborative
partners or others that require us to relinquish rights to certain technologies
or potential products. This could have a negative impact on our ability to
develop products, or to achieve profitability if our products are brought to
market. If we obtain additional funding through sales of securities, your
investment in LJPC will be diluted.


                                       19
   20

WE MAY NOT EARN AS MUCH INCOME AS WE HOPE DUE TO POSSIBLE CHANGES IN HEALTHCARE
REIMBURSEMENT POLICIES.

       The continuing efforts of government and healthcare insurance companies
to reduce the costs of healthcare may reduce the amount of income we can
generate from our products. For example, in certain foreign markets, pricing and
profitability of prescription drugs are subject to government control. In the
United States, we expect that there will continue to be a number of federal and
state proposals to implement similar government controls. In addition,
increasing emphasis on managed care in the United States will continue to put
pressure on drug manufacturers to keep prices down. Cost control initiatives
could reduce the revenue that we receive for any products we may develop and
sell in the future. These cost control measures may also affect the
profitability of companies with whom we may transact business, such as
manufacturers of our products, and thus may have a negative effect on our
ability to continue to work with these companies.

BECAUSE A NUMBER OF COMPANIES COMPETE WITH US, MANY OF WHICH HAVE GREATER
RESOURCES THAN WE DO, AND BECAUSE WE FACE RAPID CHANGES IN TECHNOLOGY IN OUR
INDUSTRY, WE CANNOT BE CERTAIN THAT OUR PRODUCTS WILL BE ACCEPTED IN THE
MARKETPLACE OR CAPTURE MARKET SHARE.

       Competition from domestic and foreign biotechnology companies, large
pharmaceutical companies and other institutions is intense and is expected to
increase. A number of companies and institutions are pursuing the development of
pharmaceuticals in our targeted areas, many of which are very large, and have
financial, technical, sales and distribution and other resources substantially
greater than ours. The greater resources of these competitors could enable them
to develop competing products more quickly than we are able to, and to market
any competing product more quickly so as to make it extremely difficult for us
to develop a share of the market for these products. These competitors also
include companies that are conducting clinical trials and preclinical studies
for the treatment of lupus. Our competitors may develop or obtain regulatory
approval for products more rapidly than we do. Also, the biotechnology and
pharmaceutical industries are subject to rapid changes in technology. Our
competitors may also develop and market technologies and products that are more
effective than those being developed by us or that would render our technology
and proposed products obsolete or noncompetitive.

WE MAY NEED TO ESTABLISH COLLABORATIVE AGREEMENTS, AND THIS COULD HAVE A
NEGATIVE EFFECT ON OUR FREEDOM TO OPERATE OUR BUSINESS, OR PROFIT FULLY FROM
SALES OF OUR PRODUCTS.

       We may seek to collaborate with pharmaceutical companies to gain access
to their research, drug development, manufacturing, marketing and financial
resources. However, we may not be able to negotiate arrangements with any
collaborative partners on acceptable terms, if at all. Any collaborative
relationships that we enter into may include restrictions on our freedom to
operate our business or to profit fully from the sales of our products.

       Once a collaborative arrangement is established, the collaborative
partner may not continue funding any particular program or may pursue
alternative technologies or develop alternative drug candidates, either alone or
with others, to develop treatments for the diseases we are targeting. Competing
products, developed by a collaborative partner or to which a collaborative
partner has rights, may result in the collaborative partner withdrawing support
as to all or a portion of our technology.

       Without collaborative arrangements, we must fund our own research and
development activities, accelerating the depletion of our capital and requiring
us to develop our own marketing


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capabilities. Therefore, if we are unable to establish and maintain
collaborative arrangements, we could experience a material adverse effect on our
ability to develop products and, once developed, to market them successfully.

OUR LIMITED MANUFACTURING CAPABILITIES COULD RESULT IN SHORTAGES OF PRODUCTS FOR
TESTING AND FUTURE SALE, AND OUR REVENUES AND PROFIT MARGIN COULD BE NEGATIVELY
AFFECTED.

       While we are producing limited quantities of LJP 394 for clinical trials,
our current facilities are not FDA approved for commercial production of our
potential products. The manufacture of our potential products for clinical
trials and the manufacture of any resulting products for commercial purposes are
subject to certain FDA standards. Substantial capital investment in the
expansion and build-out of our manufacturing facilities will be required to
enable us to manufacture any products in commercial quantities. While we have
initiated the process of obtaining FDA approval for our facilities, we have
never operated a FDA-approved manufacturing facility and may not obtain
necessary approvals. We have limited manufacturing experience, and we may be
unable to successfully transition to commercial production. We may enter into
arrangements with contract manufacturing companies to expand our own production
capacity in order to meet requirements for our products, or to attempt to
improve manufacturing efficiency. If we choose to contract for manufacturing
services and encounter delays or difficulties in establishing relationships with
manufacturers to produce, package and distribute our finished products, the
clinical trials, the introduction of our products into the market and the
subsequent sales of these products would be negatively affected by the lack of
available products, and our profit margins and our ability to develop and
deliver products on a timely and competitive basis may be negatively affected.

WE LACK EXPERIENCE IN MARKETING PRODUCTS FOR COMMERCIAL SALE AND THUS MAY HAVE
DIFFICULTY GAINING ACCEPTANCE FOR OUR PRODUCTS.

       In order to commercialize any drug candidate approved by the FDA, we must
either develop a marketing and sales force or enter into marketing arrangements
with others. If we cannot do either of these, we may have difficulty generating
sales for our products. We currently have no marketing arrangements with others,
and there can be no guarantee that we will be able to enter into any marketing
agreements on favorable terms, or that any such agreements will result in
payments to LJPC. To the extent that we enter into co-promotion or other
marketing and sales arrangements with other companies, any revenues that we may
receive will be dependent on the efforts of others. There can be no guarantee
that these efforts will be successful. If we attempt to develop our own
marketing and sales capabilities, we will compete with other companies that have
experienced and well-funded marketing and sales operations. Furthermore, if we
attempt to establish sales and distribution capabilities, we may experience
delays and expenditures and have difficulty in gaining market acceptance for our
drug candidates.

THE USE OF LJP 394 AND OTHER POTENTIAL PRODUCTS IN CLINICAL TRIALS, AND THE SALE
OF ANY APPROVED PRODUCTS MAY EXPOSE US TO LAWSUITS RESULTING FROM THE USE OF
THESE PRODUCTS.

       The use and possible sale of LJP 394 and other potential products may
expose us to legal liability and generate negative publicity if we are subject
to claims that people were harmed by our products. These claims might be made
directly by consumers, pharmaceutical companies, or others. We maintain $10.0
million of product liability insurance for claims arising from the use of LJPC
products in clinical trials. However, coverage is becoming increasingly
expensive, and there can be no guarantee that we will be able to maintain
insurance or that insurance can be acquired at a reasonable cost or in
sufficient amounts to protect us against possible losses.


                                       21
   22

Furthermore, it is possible that our financial resources would be insufficient
to satisfy potential product liability claims. A successful product liability
claim or series of claims brought against us could negatively impact our
business and financial condition.

OUR RESEARCH AND DEVELOPMENT AND OPERATIONS DEPEND IN PART ON CERTAIN KEY
EMPLOYEES AND CONSULTANTS. LOSING THESE EMPLOYEES OR CONSULTANTS WOULD HAVE A
NEGATIVE EFFECT ON OUR PRODUCT DEVELOPMENT AND OPERATIONS.

       We are highly dependent upon the principal members of our scientific and
management staff, the loss of whose services would delay the achievement of our
research and development objectives. This is because our key personnel,
including Steven Engle, Dr. Matthew Linnik, Dr. Paul Jenn and Dr. Andrew
Wiseman, have been involved in the development of LJP 394 and other drug
candidates for several years and have unique knowledge of our drug candidates
and of the technology on which they are based. Our anticipated growth and
expansion into areas requiring additional expertise, such as clinical trials,
government approvals, manufacturing, and marketing, is expected to place
increased demands on our resources and require the addition of new management
personnel as well as the development of additional expertise by existing
management personnel.

       Retaining our current key employees and recruiting additional qualified
scientific personnel to perform research and development work in the future will
also be critical to our success. Because competition for experienced scientists
among numerous pharmaceutical and biotechnology companies and research and
academic institutions is intense, we may not be able to attract and retain these
people. If we cannot attract and retain qualified people, our ability to conduct
necessary clinical trials and to develop our products may be negatively affected
because, for instance, the trials may not be conducted properly, or the trials
or our manufacturing of products may be delayed. In addition, we rely upon
consultants and advisors to assist us in formulating our research and
development, clinical, regulatory and manufacturing strategies. All of our
consultants and advisors are employed outside LJPC and may have commitments or
consulting or advisory contracts with other entities that may affect their
ability to contribute to our business.

IT IS POSSIBLE THAT WE MAY FACE ENVIRONMENTAL LIABILITIES RELATED TO CERTAIN
HAZARDOUS MATERIALS USED IN OUR OPERATIONS.

       Due to the nature of our manufacturing processes, we are subject to
stringent federal, state and local laws governing the use, handling and disposal
of certain materials and wastes. It is possible that we may have to incur
significant costs to comply with environmental regulations as our manufacturing
increases to commercial volumes. Our operations may be significantly impacted by
current or future environmental laws because, for instance, our ability to
produce products may be slowed down, which may cause our costs in producing
these products to increase. In our research activities, we use radioactive and
other materials that could be hazardous to human health, safety, or the
environment. These materials and various wastes resulting from their use are
stored at our facility pending ultimate use and disposal. The risk of accidental
injury or contamination from these materials cannot be eliminated. In the event
of such an accident, we could be held liable for any resulting damages, and any
such liability could exceed our resources.


                                       22
   23

II.    RISK FACTORS RELATED SPECIFICALLY TO OUR STOCK.

OUR COMMON STOCK PRICE IS VOLATILE AND MAY DECLINE EVEN IF OUR BUSINESS IS DOING
WELL.

       The market price of our common stock has been and is likely to continue
to be highly volatile. Market prices for securities of biotechnology and
pharmaceutical companies, including ours, have historically been highly
volatile, and the market has from time to time experienced significant price and
volume fluctuations that are unrelated to the operating performance of
particular companies. The following factors can have a significant effect on the
market price of our securities:

       -      announcements of technological innovations or new therapeutic
              products by LJPC or others,

       -      clinical trial results,

       -      developments concerning agreements with collaborators,

       -      government regulation,

       -      developments in patent or other proprietary rights,

       -      public concern as to the safety of drugs discovered or developed
              by LJPC or others,

       -      future sales of substantial amounts of our common stock by
              existing stockholders, and

       -      comments by securities analysts and general market conditions.

       The realization of any of the risks described in these "Risk Factors"
could have a negative effect on the market price of our common stock.

IN THE FUTURE, OUR STOCK MAY BE REMOVED FROM LISTING ON THE NASDAQ QUOTATION
SYSTEM AND MAY NOT QUALIFY FOR LISTING ON ANY STOCK EXCHANGE, IN WHICH CASE IT
MAY BE DIFFICULT TO FIND A MARKET IN OUR STOCK.

       If our stock is no longer traded on a national trading market it may be
more difficult for you to sell shares that you own, and the price of the stock
may be negatively affected. Currently our securities are traded on the Nasdaq
National Market. Nasdaq has certain continued listing requirements, including a
minimum trading price. Previously, we have received notice from Nasdaq that our
stock price fell below this minimum trading price. While we have since come back
into compliance with this Nasdaq requirement, it is possible that we will fall
out of compliance with this and/or other Nasdaq continued listing criteria at
some point in the future. Failure to comply with any one of several Nasdaq
requirements may cause our stock to be removed from listing on Nasdaq. Should
this happen, we may not be able to secure listing on other exchanges or
quotation systems. This would have a negative effect on the price and liquidity
of our stock.


                                       23
   24

FUTURE SALES OF OUR STOCK BY EXISTING STOCKHOLDERS COULD NEGATIVELY AFFECT THE
MARKET PRICE OF OUR STOCK AND MAKE IT MORE DIFFICULT FOR US TO SELL STOCK IN THE
FUTURE.

       Sales of our common stock in the public market, or the perception that
such sales could occur, could result in a drop in the market price of our
securities and make it more difficult for us to complete future equity
financings

ANTI-TAKEOVER DEVICES MAY PREVENT CHANGES IN MANAGEMENT OF LJPC.

       We have in place some anti-takeover devices, including a stockholder
rights plan, which may have the effect of delaying or preventing changes in the
management of LJPC. For example, one anti-takeover device provides for a board
of directors that is separated into three classes, with their terms in office
staggered over three year periods. This has the effect of delaying a change in
control of the Board of Directors without the cooperation of the incumbent
board. In addition, our bylaws do not allow stockholders to call a special
meeting of stockholders, require stockholders to give written notice of any
proposal or director nomination to us within a certain period of time prior to
the stockholder annual meeting, and establish certain qualifications for a
person to be elected or appointed to the Board of Directors during the pendency
of certain business combination transactions.

       We may also issue shares of preferred stock without stockholder approval
and upon terms that our Board of Directors may determine in the future. The
issuance of preferred stock could have the effect of making it more difficult
for a third party to acquire a majority of our outstanding stock, and the
holders of such preferred stock could have voting, dividend, liquidation and
other rights superior to those of holders of our common stock.

WE DO NOT PAY DIVIDENDS AND THIS MAY NEGATIVELY AFFECT THE PRICE OF OUR STOCK.

       We have not paid any cash dividends since our inception and do not
anticipate paying any cash dividends in the foreseeable future. The future price
of our common stock may be depressed by the fact that we have not paid
dividends.


ITEM 2. PROPERTIES.

       We lease two adjacent buildings in San Diego, California for a total of
approximately 54,000 square feet. One building contains research and development
labs and clinical manufacturing facilities which lease expires in July 2004 and
the other contains general offices and our warehouse which lease expires in
October 2001. Each building lease includes an option to extend the term of the
agreement for an additional five years and is subject to escalation clauses that
provide for annual rent increases based on the U.S. Consumer Price Index. We
believe that these facilities will be adequate to meet our needs for the near
term. Over the longer term, management believes additional space can be secured
at commercially reasonable rates.


ITEM 3. LEGAL PROCEEDINGS.

       We are currently not a party to any legal proceedings.


                                       24
   25

ITEM 4. SUBMISSION OF MATTERS TO A VOTE OF SECURITY HOLDERS.

       No matters were submitted to a vote of security holders during the three
month period ended December 31, 2000.

                                     PART II


ITEM 5. MARKET FOR REGISTRANT'S COMMON EQUITY AND RELATED STOCKHOLDER MATTERS.

       Our Common Stock trades on the Nasdaq National Market under the symbol
"LJPC." Set forth below are the high and low sales prices for our Common Stock
for each full quarterly period within the two most recent fiscal years.




                                                        Prices
Year Ended December 31, 2000                  High                    Low
                                          -----------------------------------

                                                               
         First Quarter                       12-1/4                  2-7/16
         Second Quarter                      6-5/8                   2-5/8
         Third Quarter                       9-7/8                   4-1/16
         Fourth Quarter                      10                      4

Year Ended December 31, 1999

         First Quarter                       5-3/8                   2-1/8
         Second Quarter                      3-3/4                   11/16
         Third Quarter                       31/32                   7/16
         Fourth Quarter                      3-1/8                   7/32


       We have not paid dividends on our Common Stock and we do not anticipate
paying dividends in the foreseeable future.

       The number of record holders of our Common Stock as of March 26, 2001 was
approximately 280.

       On February 9, 2001, we sold 5,700,000 shares of our Common Stock to
private investors for an aggregate price of $35.3 million. The sale was a
privately negotiated sale to selected institutional investors and other
accredited investors as defined in Rule 501(1) of Regulation D promulgated under
the Securities Act of 1933. The shares were sold without registration under the
Securities Act of 1933 in reliance on Rule 506. The sale was made for the
purpose of financing working capital. We filed a registration statement covering
the resale of these shares on Form S-3 that became effective on February 14,
2001.


ITEM 6. SELECTED FINANCIAL DATA.

       The following Selected Financial Data should be read in conjunction with
"Management's Discussion and Analysis of Financial Condition and Results of
Operations" included in Item 7 below and the financial statements of the Company
and related notes thereto beginning at page F-1 of this report.


                                       25
   26



                                                                           Years Ended December 31,
                                                     --------------------------------------------------------------------
                                                       1996           1997           1998           1999           2000
                                                     --------------------------------------------------------------------
                                                                    (In thousands, except per share data)
                                                                                                  
STATEMENT OF OPERATIONS DATA:

Revenue from collaborative agreements                $  4,000       $  9,860       $  8,600       $  4,690       $     --

Expenses:
   Research and development                            11,663         14,676         14,627         11,686         12,933
   General and administrative                           2,920          2,937          3,076          2,944          2,706
                                                     --------------------------------------------------------------------
Loss from operations                                  (10,583)        (7,753)        (9,103)        (9,940)       (15,639)

Interest expense                                         (183)           (56)            (6)           (20)            (6)
Interest income                                         1,170          1,441          1,232            811          1,846
                                                     --------------------------------------------------------------------

Net loss                                             $ (9,596)      $ (6,368)      $ (7,877)      $ (9,149)      $(13,799)
                                                     ====================================================================

Basic and diluted net loss per share                 $  (0.63)      $  (0.36)      $  (0.42)      $  (0.45)      $  (0.53)
                                                     ====================================================================

Shares used in computing basic and diluted net
  loss per share                                       15,150         17,547         18,649         20,135         26,138
                                                     ====================================================================

BALANCE SHEET DATA:

Working capital                                      $ 25,886       $ 23,705       $ 19,911       $ 10,661       $ 37,215
Total assets                                         $ 31,687       $ 29,646       $ 25,815       $ 14,043       $ 43,016
Noncurrent portion of obligations under capital
  leases                                             $    168       $     --       $     --       $     44       $     --
Stockholders' equity                                 $ 27,938       $ 25,715       $ 21,859       $ 12,793       $ 39,742



                                       26
   27

QUARTERLY RESULTS OF OPERATIONS

       The following is a summary of the quarterly results of operations for the
years ended December 31, 2000 and 1999:



                                                                            Quarters Ended

                                                          Mar. 31,      Jun. 30,       Sept. 30,      Dec. 31,
                                                         ------------------------------------------------------
                                                                                          
                2000
- -------------------------------------
Revenue from collaborative agreements                    $     --       $     --       $     --       $     --

Expenses:
   Research and development                                 2,435          2,708          4,184          3,606
   General and administrative                                 719            585            617            785
                                                         ------------------------------------------------------
Loss from operations                                       (3,154)        (3,293)        (4,801)        (4,391)

Interest expense                                               (3)            (2)            (1)            --
Interest income                                               280            301            580            685
                                                         ------------------------------------------------------

Net loss                                                 $ (2,877)      $ (2,994)      $ (4,222)      $ (3,706)
                                                         ======================================================

Basic and diluted net loss per share
                                                         $  (0.13)      $  (0.12)      $  (0.15)      $  (0.13)
                                                         ======================================================

Shares used in computing basic and diluted net loss
  per share                                                22,249         24,401         28,037         29,293
                                                         ======================================================



                 1999
- -------------------------------------
Revenue from collaborative agreements                    $  1,659       $  1,455       $  1,576       $     --

Expenses:
   Research and development                                 3,175          3,232          3,170          2,109
   General and administrative                                 822            881            717            524
                                                         ------------------------------------------------------
Loss from operations                                       (2,338)        (2,658)        (2,311)        (2,633)

Interest expense                                               (9)            (4)            (3)            (4)
Interest income                                               252            196            197            166
                                                         ------------------------------------------------------

Net loss                                                 $ (2,095)      $ (2,466)      $ (2,117)      $ (2,471)
                                                         ======================================================

Basic and diluted net loss per share
                                                         $  (0.10)      $  (0.12)      $  (0.11)      $  (0.12)
                                                         ======================================================

Shares used in computing basic and diluted net loss
  per share                                                20,109         20,111         20,160         20,162
                                                         ======================================================



                                       27
   28
       ITEM 7. MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND
               RESULTS OF OPERATIONS.

       Since our inception in May 1989, we have devoted substantially all of our
resources to the research and development of technology and potential drugs to
treat antibody-mediated diseases. We have never generated any revenue from
product sales and have relied upon private and public investors, revenue from
collaborative agreements, equipment lease financings and interest income on
invested cash balances for our working capital. We have been unprofitable since
inception and we expect to incur substantial additional expenses and net
operating losses for at least the next several years as we increase our clinical
trial and manufacturing scale-up activities including the production of LJP 394
for clinical trials, and increase our research and development expenditures on
additional drug candidates, and general and administrative expenditures to
support increased clinical trial, research and development and manufacturing
scale-up activities. Our activities to date are not as broad in depth or scope
as the activities we must undertake in the future and our historical operations
and the financial information included in this report are not necessarily
indicative of our future operating results or financial condition.

       We expect that losses are likely to exceed those experienced in prior
years due to the termination of the Abbott collaborative relationship in
September 1999. In addition, we expect losses to fluctuate from quarter to
quarter as a result of differences in the timing of expenses incurred. Some of
these fluctuations may be significant. As of December 31, 2000, our accumulated
deficit was approximately $85.6 million.

       Our business is subject to significant risks including, but not limited
to, the risks inherent in research and development efforts, including clinical
trials, uncertainties associated with both obtaining and enforcing patents and
with the patent rights of others, the lengthy, expensive and uncertain process
of seeking regulatory approvals, uncertainties regarding government reforms and
of product pricing and reimbursement levels, technological change and
competition, manufacturing uncertainties, our lack of marketing experience and
the uncertainty of receiving future revenue from product sales or other sources
such as collaborative relationships, future profitability and the need for
additional financing. Even if our product candidates appear promising at an
early stage of development, they may not reach the market for numerous reasons.
Such reasons include the possibilities that the products will be ineffective or
unsafe during clinical trials, will fail to receive necessary regulatory
approvals, will be difficult to manufacture on a large scale, will be
uneconomical to market or will be precluded from commercialization by
proprietary rights of third parties.

RESULTS OF OPERATIONS
YEARS ENDED DECEMBER 31, 2000, 1999 AND 1998

       Revenue. We earned no revenue for the year ended December 31, 2000
compared to $4.7 million and $8.6 million for the years ended December 31, 1999
and 1998, respectively. In December 1996, we entered into a collaborative
agreement with Abbott for the worldwide development and commercialization of LJP
394, our lupus drug candidate. All revenue in 1999 and 1998 was attributable to
the funding from Abbott under this collaborative agreement for the development
of LJP 394. Our collaborative agreement with Abbott granted Abbott the exclusive
right to market and sell LJP 394 throughout the world in exchange for
development funding, royalties on sales and milestone payments. Abbott's
obligations to make payments to us and to conduct development activities were
conditioned on the progress of clinical trials and the attainment of milestones
related to regulatory approvals and sales levels. In May 1999, Abbott and LJPC
elected to stop the enrollment and treatment of the more than 200 patients
enrolled in


                                       28
   29

the jointly conducted Phase II/III clinical trial of LJP 394. In September 1999,
Abbott and LJPC terminated the collaborative agreement and all rights to LJP 394
were returned to us. There can be no assurance that we will realize any further
revenue from any other collaborative arrangement.

       Research and Development Expenses. Our research and development expenses
increased to $12.9 million for the year ended December 31, 2000 from $11.7
million in 1999 and decreased from $14.6 million in 1998. The increase in
research and development expense in 2000 from 1999 was primarily due to the
initiation of the Phase III clinical trial for LJP 394 in September 2000. The
decrease in research and development expense in 1999 from 1998 was primarily due
to the decrease in expenses as a result of stopping our Phase II/III clinical
trial for LJP 394. Our research and development expenses are expected to
increase significantly in the future as clinical trial and manufacturing
scale-up activities including the production of LJP 394 for clinical trials are
increased, efforts to develop additional drug candidates are intensified, and
other potential products progress into and through clinical trials.

       General and Administrative Expenses. Our general and administrative
expenses of $2.7 million for the year ended December 31, 2000 decreased slightly
from $2.9 million in 1999 and from $3.1 million in 1998. The slight decrease in
general and administrative expense in 2000 compared to 1999 was due to the
reduction in expenses related to a restructuring completed in 1999. The slight
decrease in general and administrative expense in 1999 compared to 1998 was due
to the reduction in investor relations activities. We expect general and
administrative expenses to increase in the future to support increased clinical
trial, manufacturing scale-up and research and development activities.

       Interest Income and Expense. Our interest income increased to $1.8
million for the year ended December 31, 2000 from $0.8 million in 1999 and from
$1.2 million in 1998. The increase in interest income in 2000 was due to the
higher investment balances as a result of the net proceeds received of $12.7
million and $27.5 million from the sale of our common stock in February and July
2000, respectively. The decrease in interest income in 1999 from 1998 was due to
lower investment balances in 1999. Interest expense decreased to $6,000 for the
year ended December 31, 2000 from $20,000 in 1999 and was comparable to $6,000
in 1998. The decrease in interest expense in 2000 was due to the termination of
some capital leases in 2000. The increase in interest expense in 1999 was due to
new capital lease obligations entered into in 1999.

       Net Operating Loss Carryforwards. At December 31, 2000, we had available
net operating loss carryforwards and research tax credit carryforwards of
approximately $81.9 million and $3.9 million, respectively, for federal income
tax purposes, which will begin to expire in 2004 unless previously utilized.

LIQUIDITY AND CAPITAL RESOURCES

       From inception through December 31, 2000, we have incurred a cumulative
net loss of approximately $85.6 million and have financed our operations through
private and public offerings of securities, revenues from collaborative
agreements, capital and operating lease transactions, and interest income on
invested cash balances. As of December 31, 2000, we have raised $124.1 million
in net proceeds since inception from sales of equity securities.

       At December 31, 2000, we had $39.9 million in cash, cash equivalents and
short-term investments, as compared to $11.4 million at December 31, 1999. Our
working capital at December 31, 2000 was $37.2 million, as compared to $10.7
million at December 31, 1999. The


                                       29
   30

increase in cash, cash equivalents and short-term investments resulted from net
proceeds of approximately $12.7 million received from the sale of 4,040,000
shares of our common stock to private investors in February 2000 and net
proceeds of approximately $27.5 million received from the sale of 4,800,000
shares of our common stock to private investors in July 2000. We invest our cash
in corporate and United States Government-backed debt instruments.

       As of December 31, 2000, we had acquired an aggregate of $4.7 million in
property and equipment, of which approximately $329,000 of equipment is financed
under capital lease obligations. In addition, we lease our office and laboratory
facilities and certain equipment under operating leases. We have no material
commitments for the acquisition of property and equipment. However, we
anticipate increasing our investment in property and equipment in connection
with the enhancement of our research and development and manufacturing
facilities and capabilities.

       We intend to use our financial resources to fund clinical trials and
manufacturing scale-up activities including the production of LJP 394 for
clinical trials, research and development efforts, and for working capital and
other general corporate purposes. The amounts actually expended for each purpose
may vary significantly depending upon numerous factors, including the results of
clinical trials, the timing of regulatory applications and approvals, and
technological developments. Expenditures also will depend upon the establishment
and progression of collaborative arrangements and contract research as well as
the availability of other financings. There can be no assurance that these funds
will be available on acceptable terms, if at all.

       We anticipate that our existing capital along with the net proceeds of
approximately $33.1 million received from the sale of 5,700,000 shares of our
common stock to private investors in February 2001, and interest earned thereon,
will be sufficient to fund our operations as currently planned through 2002. Our
future capital requirements will depend on many factors, including continued
scientific progress in our research and development programs, the size and
complexity of these programs, the scope and results of clinical trials, the
analysis of data from the Phase II/III clinical trial, the time and costs
involved in applying for regulatory approvals, the costs involved in preparing,
filing, prosecuting, maintaining and enforcing patent claims, competing
technological and market developments, ability to establish and maintain
collaborative relationships, and the cost of manufacturing scale-up and
effective commercialization activities and arrangements. We expect to incur
significant net operating losses each year for at least the next several years
as we expand our current research and development programs, including clinical
trials and manufacturing scale-up activities, and increase our general and
administrative expenses to support a larger, more complex organization. It is
possible that our cash requirements will exceed current projections and that we
will therefore need additional financing sooner than currently expected.

       We have no current means of generating cash flow from operations. Our
lead drug candidate, LJP 394, will not generate revenues, if at all, until it
has been proven safe and effective, has received regulatory approval and has
been successfully commercialized, a process that is expected to take at least
the next several years. Our other drug candidates are much less developed than
LJP 394. There can be no assurance that our product development efforts with
respect to LJP 394 or any other drug candidate will be successfully completed,
that required regulatory approvals will be obtained, or that any product, if
introduced, will be successfully marketed or achieve commercial acceptance.
Accordingly, we must continue to rely upon outside sources of financing to meet
our capital needs for the foreseeable future.


                                       30
   31

       We will continue to seek capital through any appropriate means, including
issuance of our securities and establishment of additional collaborative
arrangements. However, there can be no assurance that additional financing will
be available on acceptable terms and our negotiating position in capital-raising
efforts may worsen as we continue to use existing resources. There is no
assurance that we will be able to enter into further collaborative
relationships.


ITEM 7A. QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK.

       We invest our excess cash in interest-bearing investment-grade securities
that we hold for the duration of the term of the respective instrument. We do
not utilize derivative financial instruments, derivative commodity instruments
or other market risk sensitive instruments, positions or transactions in any
material fashion. Accordingly, we believe that, while the investment-grade
securities we hold are subject to changes in the financial standing of the
issuer of such securities, we are not subject to any material risks arising from
changes in interest rates, foreign currency exchange rates, commodity prices or
other market changes that affect market risk sensitive instruments.


ITEM 8. FINANCIAL STATEMENTS AND SUPPLEMENTARY DATA.

       The financial statements and supplementary data required by this item are
at the end of this report beginning on page F-1.


ITEM 9. CHANGES IN AND DISAGREEMENTS WITH ACCOUNTANTS ON ACCOUNTING AND
        FINANCIAL DISCLOSURE.

       None.



                                    PART III


ITEM 10. DIRECTORS AND EXECUTIVE OFFICERS OF THE REGISTRANT.

       Our executive officers and key employees and their ages are set forth
below.

                                       
Steven B. Engle                     46       Chairman of the Board, Chief Executive Officer

Matthew D. Linnik, Ph.D.            41       Executive Vice President of Research, Assistant
                                             Secretary

Andrew Wiseman, Ph.D.               52       Senior Director of Business Development

Paul Jenn, Ph.D.                    50       Vice President of Operations

Theodora Reilly                     51       Vice President of Human Resources

Gail A. Sloan, CPA                  38       Controller, Secretary




                                       31
   32

       STEVEN B. ENGLE, Chairman of the Board and Chief Executive Officer,
joined the Company in 1993 as Executive Vice President and Chief Operating
Officer. He assumed the offices of President, Director and Secretary in 1994,
and became Chief Executive Officer in 1995, and Chairman of the Board in 1997.
From 1991 to 1993, Mr. Engle served as Vice President of Marketing and in other
senior management positions while at Cygnus Inc., a publicly held company that
develops drug-delivery systems for therapeutic drugs. From 1987 to 1991, he was
Chief Executive Officer of Quantum Management Company, a privately held
management consulting firm serving the pharmaceutical industry. From 1984 to
1987, he was Vice President of Marketing and Divisional General Manager for
Micro Power Systems Inc., a privately held company that manufactures high
technology products including medical devices. From 1979 to 1984, he was a
management consultant at Strategic Decisions Group and SRI International where
he advised pharmaceutical, high technology and other companies. Mr. Engle was
the former Chairman of BIOCOM, a regional trade association for the
biotechnology and medical devices industries, and is a member of the Board of
the Lupus Foundation of America. Mr. Engle holds an M.S.E.E. and a B.S.E.E. with
a focus in biomedical engineering from the University of Texas.

       MATTHEW D. LINNIK, Ph.D., Executive Vice President of Research, joined
the Company in 1998 as Director of Research and Development, and was promoted to
Vice President of Research in 1999 and then Executive Vice President of Research
in 2000. Prior to joining the Company, from 1989 to 1998, Dr. Linnik served as
Senior Pharmacologist, Scientist, Research Scientist and Project Leader for
Hoechst Marion Roussel, formerly Marion Merrell Dow and Marion Laboratories, a
pharmaceutical company. From 1996 to 1998, he also served as Adjunct Associate
Professor of Neurosurgery at the University of Cincinnati School of Medicine.
From 1986 to 1988, he served as Postdoctoral Fellow, then Instructor, in the
Departments of Neurology and Neurosurgery at Massachusetts General Hospital and
Harvard Medical School. Dr. Linnik holds a B.A. in Physiology from Southern
Illinois University and a Ph.D. in Physiology and Pharmacology from Southern
Illinois University School of Medicine.

       ANDREW WISEMAN, Ph.D., Senior Director of Business Development, joined
the Company in May 1989 as Director of Business Development and was one of the
Company's original founders. Dr. Wiseman has also served as head of investor
relations since 1994. From 1983 to 1989, Dr. Wiseman held several positions with
Quidel Corporation, including Manager of Business Development, Project Manager
in Diagnostic Research and Development and Senior Research Scientist. Dr.
Wiseman was an Assistant Professor at the Medical Biology Institute and an
Assistant Member at the Scripps Clinic and Research Foundation. He received a
B.S. in Zoology and a Ph.D. in Genetics from Duke University.

       PAUL JENN, Ph.D., Vice President of Operations, joined the Company in
1994 as Associate Director of Production & Process Development. Dr. Jenn was
promoted to Director of Operations in 1999, Senior Director of Operations in
2000, and Vice President of Operations in 2001. Prior to joining the Company,
from 1992 to 1994, Dr. Jenn was Director of Peptide Manufacturing at Telios
Pharmaceuticals, Inc. a pharmaceutical company, and held several other
positions. From 1988 to 1992, he served as Senior Research Associate at
Mallinckrodt Specialty Chemicals, a specialty chemical company. From 1984 to
1988, Dr. Jenn served as a Research Scientist at International Minerals and
Chemical Corp., a chemical company. From 1982 to 1984, he performed his
Post-doctoral research at the Lawrence Berkeley Laboratory at the University of
California at Berkley. Dr. Jenn holds a B.S. in Chemistry from Fu-Jen Catholic
University, Taipei, Taiwan and a Ph.D. in Chemistry from New York State
University at Buffalo.

       THEODORA REILLY, Vice President of Human Resources, joined the Company in
1998 as Director of Human Resources and was promoted to Vice President of Human
Resources


                                       32
   33

in 2001. Prior to joining the Company, from 1997 to 1998, Ms. Reilly was
Director of Human Resources at ThermoLase Corporation, a public subsidiary of
Thermo Electron Corporation, which developed laser-based systems for laser-based
skin resurfacing. From 1994 to 1997, Ms. Reilly served as Director of Human
Resources at Solectek Corporation, a privately held high tech manufacturer of
wireless interconnectivity products. Ms. Reilly received a B.S. in Psychology
from the Christian Bible College and Seminary, Independence, MO.

       GAIL A. SLOAN, Controller, joined the Company in 1996 as Assistant
Controller. Prior to joining the Company, from 1993 to 1996, Ms. Sloan served as
Assistant Controller at Affymax Research Institute, a drug discovery research
company and a part of the Glaxo Wellcome Group. From 1985 to 1993, she
progressed to the position of Audit Manager with Ernst & Young, LLP. Ms. Sloan
holds a B.S. in Business Administration from California Polytechnic State
University at San Luis Obispo and is a Certified Public Accountant.

       Other information for Item 10 is incorporated by reference from portions
of our definitive proxy statement for the annual meeting of stockholders to be
held on May 18, 2001 under the captions "Proposal 1 -- Election of Directors"
and "Section 16(a) Beneficial Ownership Reporting Compliance," which will be
filed with the Securities and Exchange Commission no later than 120 days after
the close of the fiscal year ended December 31, 2000.


ITEM 11. EXECUTIVE COMPENSATION.

       Information for Item 11 is incorporated by reference from portions of our
definitive proxy statement for the annual meeting of stockholders to be held on
May 18, 2001 under the captions "Executive Compensation and Other Information,"
"Report of the Compensation Committee on Executive Compensation," "Compensation
Committee Interlocks and Insider Participation," and "Stock Performance Graph,"
which will be filed with the Securities and Exchange Commission no later than
120 days after the close of the fiscal year ended December 31, 2000.


ITEM 12. SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT.

       Information for Item 12 is incorporated by reference from the portion of
our definitive proxy statement for the annual meeting of stockholders to be held
on May 18, 2001 entitled "Security Ownership of Certain Beneficial Owners and
Management," which will be filed with the Securities and Exchange Commission no
later than 120 days after the close of the fiscal year ended December 31, 2000.


ITEM 13. CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS.

       None.



                                       33
   34
                                    PART IV

ITEM 14. EXHIBITS, FINANCIAL STATEMENT SCHEDULES, AND REPORTS ON FORM 8-K.

              (a) Documents filed as part of this report:

                                                                                           
                     1. Financial Statements.

                        The following financial statements of La Jolla
                        Pharmaceutical Company are included in Item 8:

                        Report of Independent Auditors........................................F-1

                        Balance Sheets at December 31, 2000 and 1999..........................F-2

                        Statements of Operations for the years
                        ended December 31, 2000, 1999 and 1998................................F-3

                        Statements of Stockholders' Equity for the years
                        ended December 31, 2000, 1999 and 1998................................F-4

                        Statements of Cash Flows for the years
                        ended December 31, 2000, 1999 and 1998................................F-5

                        Notes to Financial Statements.........................................F-6

                     2. Financial Statement Schedules.

                        No financial statement schedules are required.




                                       34
   35

                 3. Exhibits.



Exhibit
Number           Description
- --------         -----------
              
3.1              Intentionally omitted

3.2              Amended and Restated Bylaws of the Company (15)

3.3              Amended and Restated Certificate of Incorporation of the Company (13)

4.0              Rights Agreement dated as of December 3, 1998 between the Company and American
                 Stock Transfer & Trust Company (11) and Amendment to Rights Agreement (16)

4.1              Certificate of Designation, Preferences and Rights of Series A Junior Participating
                 Preferred Stock of the Company (12)

10.1             Intentionally omitted

10.2             Stock Option Agreement dated February 4, 1993 entitling Joseph Stemler to purchase
                 35,000 shares of Common Stock (1) *

10.3             Intentionally omitted

10.4             Intentionally omitted

10.5             Intentionally omitted

10.6             Steven B. Engle Employment Agreement (1), Amendment No. 1 (9) and Amendment No. 2 (15)*

10.7             Form of Directors and Officers Indemnification Agreement (1)

10.8             Intentionally omitted

10.9             Intentionally omitted

10.10            Option and Collaborative Research Agreement dated June 10, 1991 regarding certain
                 compounds for potential treatment of muscular dystrophies or myasthenia gravis between
                 the Company and CepTor Corporation (1)

10.11            Intentionally omitted

10.12            Intentionally omitted

10.13            Form of Employee Invention and Confidential Information Agreement (1)

10.14            Industrial Real Estate Lease (1)

10.15            Intentionally omitted

10.16            Intentionally omitted

10.17            La Jolla Pharmaceutical Company 1989 Incentive Stock Option Plan and 1989
                 Nonstatutory Stock Option Plan (1) *

10.18            Form of Stock Option Agreement under the 1989 Nonstatutory Stock Option Plan (1)

10.19            La Jolla Pharmaceutical Company 1994 Stock Incentive Plan (Amended and Restated
                 as of July 21, 2000)  (15)*

10.20            La Jolla Pharmaceutical Company 1995 Employee Stock Purchase Plan (Amended and
                 Restated as of March 19, 2001) (17)*

10.21            Letter of Agreement dated June 7, 1993 between the Company and Vector Securities
                 International regarding Vector's engagement as financial advisor to the Company with
                 respect to potential corporate strategic alliances (1)

10.22            Intentionally omitted



                                       35
   36

              
10.23            Intentionally omitted

10.24            Intentionally omitted

10.25            Second Amendment to Lease dated June 30, 1994 by and between the Company and BRE
                 Properties, Inc. (2)

10.26            Intentionally omitted

10.27            Third Amendment to Lease dated January 26, 1995 by and between the Company and
                 BRE Properties, Inc. (3)

10.28            Intentionally omitted

10.29            Master Lease Agreement dated September 13, 1995 by and between the Company and
                 Comdisco Electronics Group (4)

10.30            Intentionally omitted

10.31            Agreement dated September 22, 1995 between the Company and Joseph Stemler regarding
                 option vesting (5) *

10.32            Intentionally omitted

10.33            Building Lease Agreement effective November 1, 1996 by and between the Company and
                 WCB II-S BRD Limited Partnership (6)

10.34            Master Lease Agreement dated December 20, 1996 by and between the Company and
                 Transamerica Business Credit Corporation (8)

10.35            License and Supply Agreement dated December 23, 1996 by and between the
                 Company and Abbott Laboratories (7), (8)

10.36            Stock Purchase Agreement dated December 23, 1996 by and between the Company and
                 Abbott Laboratories (8) and Waiver of Contractual Restrictions dated February 6, 2001 (17)

10.37            Intentionally omitted

10.38            Master Lease Agreement No. 2 dated June 23, 1998 by and between the Company and
                 Transamerica Business Credit Corporation (10)

10.39            Intentionally omitted

10.40            Supplement to employment offer letter for Matthew Linnik, Ph.D. (14)*

23.1             Consent of Ernst & Young LLP, Independent Auditors (17)



- ----------

*      This exhibit is a management contract or compensatory plan or
       arrangement.

(1)    Previously filed with the Company's Registration Statement on Form S-1
       (No. 33-76480) as declared effective by the Securities and Exchange
       Commission on June 3, 1994.

(2)    Previously filed with the Company's quarterly report on Form 10-Q for the
       quarter ended June 30, 1994 and incorporated by reference herein.

(3)    Previously filed with the Company's quarterly report on Form 10-Q for the
       quarter ended March 31, 1995 and incorporated by reference herein.

(4)    Previously filed with the Company's quarterly report on Form 10-Q for the
       quarter ended September 30, 1995 and incorporated by reference herein.

(5)    Previously filed with the Company's annual report on Form 10-K for the
       fiscal year ended December 31, 1995 and incorporated by reference herein.

(6)    Previously filed with the Company's quarterly report on Form 10-Q for the
       quarter ended September 30, 1996 and incorporated by reference herein.

(7)    Portions of the Exhibit 10.35 have been omitted and filed separately with
       the Securities and Exchange Commission pursuant to a request for
       confidential treatment under Rule 24b-2 of the Securities Exchange Act of
       1934.


                                       36
   37

(8)    Previously filed with the Company's annual report on Form 10-K for the
       fiscal year ended December 31, 1996 and incorporated by reference herein.

(9)    Previously filed with the Company's quarterly report on Form 10-Q for the
       quarter ended June 30, 1997 and incorporated by reference herein.

(10)   Previously filed with the Company's quarterly report on Form 10-Q for the
       quarter ended June 30, 1998 and incorporated by reference herein.

(11)   Previously filed with the Company's Registration Statement on Form 8-A
       (No. 000-24274) as filed with the Securities and Exchange Commission on
       December 4, 1998.

(12)   Previously filed with the Company's quarterly report on Form 10-Q for the
       quarter ended June 30, 1999 and incorporated by reference herein.

(13)   Previously filed with the Company's quarterly report on Form 10-Q for the
       quarter ended September 30, 1999 and incorporated by reference herein.

(14)   Previously filed with the Company's annual report on Form 10-K for the
       fiscal year ended December 31, 1999 and incorporated by reference herein

(15)   Previously filed with the Company's quarterly report on Form 10-Q for the
       quarter ended September 30, 2000 and incorporated by reference herein.

(16)   Previously filed with the Company's report on Form 8-K filed on January
       26, 2001 and incorporated by reference herein.

(17)   Filed herein.



              (b) Reports on Form 8-K:

                  None.


                                       37
   38

                         Report of Independent Auditors



The Board of Directors and Stockholders
La Jolla Pharmaceutical Company

We have audited the accompanying balance sheets of La Jolla Pharmaceutical
Company as of December 31, 2000 and 1999, and the related statements of
operations, stockholders' equity, and cash flows for each of the three years in
the period ended December 31, 2000. These financial statements are the
responsibility of the Company's management. Our responsibility is to express an
opinion on these financial statements based on our audits.

We conducted our audits in accordance with auditing standards generally accepted
in the United States. Those standards require that we plan and perform the audit
to obtain reasonable assurance about whether the financial statements are free
of material misstatement. An audit includes examining, on a test basis, evidence
supporting the amounts and disclosures in the financial statements. An audit
also includes assessing the accounting principles used and significant estimates
made by management, as well as evaluating the overall financial statement
presentation. We believe that our audits provide a reasonable basis for our
opinion.

In our opinion, the financial statements referred to above present fairly, in
all material respects, the financial position of La Jolla Pharmaceutical Company
at December 31, 2000 and 1999, and the results of its operations and its cash
flows for each of the three years in the period ended December 31, 2000, in
conformity with accounting principles generally accepted in the United States.




                                        ERNST & YOUNG LLP


San Diego, California
February 8, 2001


                                      F-1
   39

                         La Jolla Pharmaceutical Company

                                 Balance Sheets

                 (In thousands, except share and per share data)




                                                                                              DECEMBER 31,
                                                                                       -------------------------
                                                                                         2000            1999
                                                                                       -------------------------
                                                                                                 
ASSETS
Current assets:
   Cash and cash equivalents                                                           $   8,061       $   4,409
   Short-term investments                                                                 31,838           6,994
   Other current assets                                                                      590             464
                                                                                       -------------------------
      Total current assets                                                                40,489          11,867

Property and equipment, net                                                                  780             658

Patent costs and other assets, net                                                         1,747           1,518
                                                                                       -------------------------
                                                                                       $  43,016       $  14,043
                                                                                       =========================
LIABILITIES AND STOCKHOLDERS' EQUITY
Current liabilities:
   Accounts payable                                                                    $     468       $     225
   Accrued clinical expenses                                                               1,914              --
   Accrued expenses                                                                          560             520
   Accrued payroll and related expenses                                                      288             262
   Current portion of obligations under capital leases                                        44             199
                                                                                       -------------------------
      Total current liabilities                                                            3,274           1,206

Noncurrent portion of obligations under capital leases                                        --              44

Commitments

Stockholders' equity:
Preferred stock, $.01 par value; 8,000,000 shares authorized, no shares issued or
   outstanding                                                                                --              --
Common stock, $.01 par value; 100,000,000 shares authorized, 29,393,078 and
   20,204,424 shares issued and outstanding at December 31, 2000 and 1999,
   respectively                                                                              294             202
Additional paid-in capital                                                               124,909          84,358
Other comprehensive income                                                                   105              --
Accumulated deficit                                                                      (85,566)        (71,767)
                                                                                       -------------------------
      Total stockholders' equity                                                          39,742          12,793
                                                                                       -------------------------
                                                                                       $  43,016       $  14,043
                                                                                       =========================



See accompanying notes.


                                      F-2
   40

                         La Jolla Pharmaceutical Company

                            Statements of Operations

                      (In thousands, except per share data)





                                                                           YEARS ENDED DECEMBER 31,
                                                                   --------------------------------------
                                                                     2000           1999           1998
                                                                   --------------------------------------
                                                                                        
Revenues:
   Revenue from collaborative agreement - related party            $     --       $  4,690       $  8,600

Expenses:
   Research and development                                          12,933         11,686         14,627
   General and administrative                                         2,706          2,944          3,076
                                                                   --------------------------------------
      Total expenses                                                 15,639         14,630         17,703

                                                                   --------------------------------------
Loss from operations                                                (15,639)        (9,940)        (9,103)

Interest expense                                                         (6)           (20)            (6)
Interest income                                                       1,846            811          1,232

                                                                   --------------------------------------
Net loss                                                           $(13,799)      $ (9,149)      $ (7,877)
                                                                   ======================================
Basic and diluted net loss per share                               $  (0.53)      $  (0.45)      $  (0.42)
                                                                   ======================================
Shares used in computing basic and diluted net loss per share        26,138         20,135         18,649
                                                                   ======================================



See accompanying notes.


                                      F-3
   41

                         La Jolla Pharmaceutical Company


                       Statements of Stockholders' Equity

              For the Years Ended December 31, 1998, 1999 and 2000





(In thousands)                                 COMMON STOCK       ADDITIONAL                                 OTHER         TOTAL
                                             ------------------    PAID-IN      DEFERRED    ACCUMULATED  COMPREHENSIVE STOCKHOLDERS'
                                             SHARES     AMOUNT     CAPITAL    COMPENSATION    DEFICIT        INCOME       EQUITY
                                             ---------------------------------------------------------------------------------------
                                                                                                  
Balance at December 31, 1997                 18,160     $   182    $  80,304     $  (30)    $ (54,741)      $    --     $  25,715
   Issuance of common stock                   1,538          15        3,767         --            --            --         3,782
   Issuance of common stock under
      Employee Stock Purchase Plan               43          --          128         --            --            --           128
   Exercise of stock options                    365           4           85         --            --            --            89
   Amortization of deferred compensation         --          --           --         22            --            --            22
   Adjustment to deferred compensation
        for terminations                         --          --           (8)         8            --            --            --
   Net loss                                      --          --           --         --        (7,877)           --        (7,877)
                                             ---------------------------------------------------------------------------------------
Balance at December 31, 1998                 20,106         201       84,276         --       (62,618)           --        21,859
   Issuance of common stock under
        Employee Stock Purchase Plan             78           1           53         --            --            --            54
   Exercise of stock options                     20          --           29         --            --            --            29
   Net loss                                      --          --           --         --        (9,149)           --        (9,149)
                                             ---------------------------------------------------------------------------------------
Balance at December 31, 1999                 20,204         202       84,358         --       (71,767)           --        12,793
   Issuance of common stock                   8,840          88       40,156         --            --            --        40,244
   Issuance of common stock under
        Employee Stock Purchase Plan            186           2          189         --            --            --           191
   Exercise of stock options                    159           2          196         --            --            --           198
   Exercise of warrants                           4          --           10         --            --            --            10
   Net loss                                      --          --           --         --       (13,799)           --       (13,799)
   Net unrealized gains on available-for-sale
        securities                               --          --           --         --            --           105           105
                                                                                                                        ---------
   Comprehensive loss                                                                                                     (13,694)
                                             ---------------------------------------------------------------------------------------
Balance at December 31, 2000                 29,393     $   294    $ 124,909     $   --     $ (85,566)      $   105     $  39,742
                                             =======================================================================================



See accompanying notes.


                                      F-4
   42

                         La Jolla Pharmaceutical Company

                            Statements of Cash Flows
                                 (In thousands)




                                                                                         YEARS ENDED DECEMBER 31,
                                                                                  --------------------------------------
                                                                                    2000           1999           1998
                                                                                  --------------------------------------
                                                                                                       
OPERATING ACTIVITIES
Net loss                                                                          $(13,799)      $ (9,149)      $ (7,877)
Adjustments to reconcile net loss to net cash used for
  operating activities:
      Depreciation and amortization                                                    381            357            367
      Write-off of property and equipment                                               --             --              8
      Deferred compensation amortization                                                --             --             22
      Accretion of interest income                                                    (634)            --             --
      Changes in operating assets and liabilities:
         Other current assets                                                         (126)            53            141
         Accrued clinical expenses                                                   1,914             --             --
         Accounts payable and accrued expenses                                         283         (1,084)          (307)
         Accrued payroll and related expenses                                           26            (93)           (22)
         Deferred revenue - related party                                               --         (1,769)           492
                                                                                  --------------------------------------
              Net cash used for operating activities                               (11,955)       (11,685)        (7,176)

INVESTING ACTIVITIES
Purchases of short-term investments                                                (40,716)       (12,289)       (20,576)
Sales of short-term investments                                                     13,439          6,667          2,500
Maturities of short-term investments                                                 3,172         10,802         20,881
Additions to property and equipment                                                   (541)          (180)           (55)
Proceeds from sale of property and equipment                                            97            275             --
Increase in patent costs and other assets                                             (288)          (275)          (258)
                                                                                  --------------------------------------
              Net cash (used for) provided by investing activities                 (24,837)         5,000          2,492

FINANCING ACTIVITIES
Net proceeds from issuance of common stock                                          40,643             83            217
Net proceeds from issuance of common stock to related party                             --             --          3,782
Payments on obligations under capital leases                                          (199)          (165)          (138)
                                                                                  --------------------------------------
              Net cash provided by (used for) financing activities                  40,444            (82)         3,861

                                                                                  --------------------------------------
Increase (decrease) in cash and cash equivalents                                     3,652         (6,767)          (823)
Cash and cash equivalents at beginning of period                                     4,409         11,176         11,999
                                                                                  --------------------------------------
Cash and cash equivalents at end of period                                        $  8,061       $  4,409       $ 11,176
                                                                                  ======================================
SUPPLEMENTAL DISCLOSURE OF CASH FLOW INFORMATION:
Interest paid                                                                     $      6       $     20       $      6
                                                                                  ======================================
SUPPLEMENTAL SCHEDULE OF NONCASH INVESTING AND FINANCING ACTIVITIES:
Capital lease obligations incurred for property and equipment                     $     --       $    405       $     --
                                                                                  ======================================
Other comprehensive income on investments                                         $    105       $     --       $     --
                                                                                  ======================================
Adjustment to deferred compensation for terminations                              $     --       $     --       $      8
                                                                                  ======================================



See accompanying notes


                                      F-5
   43

                         La Jolla Pharmaceutical Company

                          Notes to Financial Statements

1. ORGANIZATION AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES

ORGANIZATION AND BUSINESS ACTIVITY

La Jolla Pharmaceutical Company (the "Company") is a biopharmaceutical company
focused on the research and development of highly specific therapeutics for the
treatment of certain life-threatening antibody-mediated diseases. These
diseases, including autoimmune conditions such as systemic lupus erythematosus
("lupus") and antibody-mediated stroke, are caused by abnormal B cell production
of antibodies that attack healthy tissues. Current therapies for these
autoimmune disorders target the symptoms of the disease or nonspecifically
suppress the normal operation of the immune system, frequently resulting in
severe, adverse side effects and hospitalization. The Company's drug candidates,
called Toleragens(R), are designed to treat the underlying cause of many
antibody-mediated diseases without these severe, adverse side effects. The
Company's clinical drug candidate for the treatment of lupus is known as LJP
394.

The Company actively seeks additional financing to fund its research and
development efforts and commercialize its technologies. There is no assurance
such financing will be available to the Company when required or that such
financing would be available under favorable terms.

The Company believes that patents and other proprietary rights are important to
its business. The Company's policy is to file patent applications to protect
technology, inventions and improvements to its inventions that are considered
important to the development of its business. The patent positions of
biotechnology firms, including the Company, are uncertain and involve complex
legal and factual questions for which important legal principles are largely
unresolved. There can be no assurance that any additional patents will be
issued, or that the scope of any patent protection will be sufficient, or that
any current or future issued patent will be held valid if subsequently
challenged.

USE OF ESTIMATES

The preparation of financial statements in conformity with generally accepted
accounting principles requires management to make estimates and assumptions that
affect the amounts reported in the financial statements and disclosures made in
the accompanying notes to the financial statements. Actual results could differ
from those estimates.

RECLASSIFICATION

Certain amounts in the 1999 and 1998 financial statements have been reclassified
to conform to the 2000 presentation.


                                      F-6
   44

                         La Jolla Pharmaceutical Company

                          Notes to Financial Statements

1. ORGANIZATION AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (CONTINUED)

CASH, CASH EQUIVALENTS AND SHORT-TERM INVESTMENTS

Cash and cash equivalents consist of cash and highly liquid investments which
include debt securities with remaining maturities when acquired of three months
or less and are stated at market. Short-term investments mainly consist of debt
securities with maturities greater than three months. Management has classified
the Company's cash equivalents and short-term investments as available-for-sale
securities in the accompanying financial statements. Available-for-sale
securities are stated at fair market value, with unrealized gains and losses
reported in other comprehensive income (loss). Realized gains and losses and
declines in value judged to be other-than-temporary on available-for-sale
securities are included in interest income and have been immaterial for each of
the years presented. The cost of securities sold is based on the specific
identification method. Interest and dividends on securities classified as
available-for-sale are included in interest income.

CONCENTRATION OF RISK

Cash, cash equivalents and short-term investments are financial instruments
which potentially subject the Company to concentrations of credit risk. The
Company deposits its cash in financial institutions. At times, such deposits may
be in excess of insured limits. The Company invests its excess cash in United
States Government securities and debt instruments of financial institutions and
corporations with strong credit ratings. The Company has established guidelines
relative to the diversification of its cash investments and their maturities in
an effort to maintain safety and liquidity. These guidelines are periodically
reviewed and modified to take advantage of trends in yields and interest rates.
To date, the Company has not experienced any impairment losses on its cash, cash
equivalents and short-term investments.

DERIVATIVE INSTRUMENTS AND HEDGING ACTIVITIES

In June 1998, the Financial Accounting Standards Board issued Statement of
Financial Accounting Standard No. 133, "Accounting for Derivative Instruments
and Hedging Activities" ("SFAS 133"). SFAS 133 provides a comprehensive and
consistent standard for the recognition and measurement of derivatives and
hedging activities. SFAS 133 was amended in June 2000 by Financial Accounting
Standard No. 138, "Accounting for Certain Derivative Instruments and Certain
Hedging Activities -- An Amendment of FASB Statement 133", ("SFAS 138"). SFAS
138 addresses a limited number of SFAS 133 implementation issues. SFAS 138 is
effective for fiscal years beginning after June 15, 2000. The adoption of this
statement is not expected to have a significant effect on the financial position
or results of operations of the Company.


                                      F-7
   45

                         La Jolla Pharmaceutical Company

                          Notes to Financial Statements

1. ORGANIZATION AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (CONTINUED)

PROPERTY AND EQUIPMENT

Property and equipment is stated at cost and depreciated using the straight-line
method over the estimated useful lives of the assets (primarily five years).
Leasehold improvements and equipment under capital leases are stated at cost and
amortized on a straight-line basis over the shorter of the estimated useful life
or the lease term.

Property and equipment is comprised of the following (in thousands):



                                                           DECEMBER 31,
                                                        2000         1999
                                                      ---------------------
                                                              
Laboratory equipment                                  $ 3,274       $ 3,279
Computer equipment                                        521           297
Furniture and fixtures                                    115           108
Leasehold improvements                                    740           702
                                                      ---------------------
                                                        4,650         4,386
Less:  Accumulated depreciation and amortization       (3,870)       (3,728)
                                                      ---------------------
                                                      $   780       $   658
                                                      =====================


IMPAIRMENT OF LONG-LIVED ASSETS

The Company records impairment losses on long-lived assets used in operations
when events and circumstances indicate that assets might be impaired and the
undiscounted cash flows estimated to be generated by those assets are less than
the carrying amount of those assets. The Company also records the assets to be
disposed of at the lower of their carrying amount or fair value less cost to
sell. To date, the Company has not experienced any impairment losses on its
long-lived assets used in operations. While the Company's current and historical
operating and cash flow losses are indicators of impairment, the Company
believes the future cash flows to be received support the carrying value of its
long-lived assets and accordingly, the Company has not recognized any impairment
losses as of December 31, 2000.

PATENTS

The Company has filed several patent applications with the United States Patent
and Trademark Office and in foreign countries. Legal costs and expenses incurred
in connection with pending patent applications have been deferred. Costs related
to successful patent applications are amortized using the straight-line method
over the lesser of the remaining useful life of the related technology or the
remaining patent life, commencing on the date the patent is issued. Total cost
and accumulated amortization were $1,823,000 and $225,000 at December 31, 2000
and $1,555,000 and $166,000 at December 31, 1999, respectively. Deferred costs
related to patent applications are charged to operations at the time a
determination is made not to pursue such applications.


                                      F-8
   46

                         La Jolla Pharmaceutical Company

                          Notes to Financial Statements

1. ORGANIZATION AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (CONTINUED)

STOCK-BASED COMPENSATION

As allowed under Statement of Financial Accounting Standard No. 123, "Accounting
and Disclosure of Stock-Based Compensation" ("SFAS 123"), the Company has
elected to continue to account for stock option grants in accordance with
Accounting Principles Board Opinion No. 25, "Accounting for Stock Issued to
Employees" ("APB 25") and related interpretations. Pursuant to APB 25,
compensation expense for employee or director stock options represents the
difference between the exercise price and the fair value of the common stock on
the date of grant. This compensation expense is amortized to expense in
accordance with FASB Interpretation No. 28 over the vesting period of the
options. The Company generally grants stock options for a fixed number of shares
to employees and directors with an exercise price equal to the fair value of the
shares at the date of grant and therefore, under APB 25, recognized no
compensation expense for such stock option grants.

Options or stock awards issued to non-employees have been determined in
accordance with SFAS 123 and EITF 96-18. Deferred charges for options granted to
non-employees are periodically remeasured as the options vest. There were no
options granted to non-employees or charges related to non-employee stock
options in the current period.

In March 2000, the Financial Accounting Standards Board ("FASB") issued FASB
Interpretation No. 44, Accounting for Certain Transactions Involving Stock
Compensation ("FIN 44"). FIN 44 clarifies certain issues in the application of
Accounting Principles Board Opinion No. 25. FIN 44 is effective July 1, 2000,
but certain conclusions cover specific events that occur after either December
15, 1998, or January 12, 2000. The adoption of FIN 44 did not have a material
impact on the Company's financial statements.

REVENUE RECOGNITION

Revenue from collaborative agreements typically consists of ongoing research and
development funding and milestone, royalty and other payments, which are
nonrefundable. Revenue from ongoing research and development funding is recorded
as the expenses are incurred. Revenue from milestone, royalty and other payments
will be recognized when the achievement of the milestone criteria, royalty
generating events or other criteria according to the collaborative agreement
have occurred. Payments received in advance under these agreements are recorded
as deferred revenue until earned.

In December 1999, the Securities and Exchange Commission staff issued Staff
Accounting Bulletin No. 101, Revenue Recognition in Financial Statements ("SAB
101"). SAB 101 formalizes the basic revenue recognition criteria that must be
met in order to record revenue. In June 2000, SAB 101 was amended to delay the
implementation date to the fourth quarter of 2000 to provide additional time to
study the guidance. There were no up-front payments or license fees received
during 2000 or in prior years which were subject to the adoption of SAB 101 as
all fees received related to agreements under which the research portion of the
collaboration had been completed, the scientific milestones had been achieved or
the agreements had been terminated entirely.


                                      F-9
   47

                         La Jolla Pharmaceutical Company

                          Notes to Financial Statements

1. ORGANIZATION AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (CONTINUED)

NET LOSS PER SHARE

Basic and diluted net loss per share is computed using the weighted-average
number of common shares outstanding during the periods in accordance with
Statement of Financial Accounting Standard No. 128, "Earnings per Share". As the
Company has incurred a net loss for all three years presented, stock options and
warrants are not included in the computation of net loss per share since their
effect is anti-dilutive.

COMPREHENSIVE LOSS

In accordance with Statement of Financial Accounting Standard No. 130,
"Reporting Comprehensive Income (Loss)" ("SFAS 130"), unrealized gains and
losses on available-for-sale securities are included in other comprehensive
income (loss), net of taxes.

SEGMENT INFORMATION

On January 1, 1998, the Company adopted Statement of Financial Accounting
Standard No. 131, "Segment Information" ("SFAS 131"). SFAS 131 redefines
segments and requires companies to report financial and descriptive information
about their operating segments. The Company has determined that it operates in
one business segment.

2. COLLABORATIVE AGREEMENTS

In September 1999, following the May 1999 suspension of the jointly conducted
Phase II/III clinical trial of LJP 394, Abbott and the Company terminated the
collaborative agreement which was entered into in December 1996 and all rights
to LJP 394 were returned to the Company. Under the agreement, in exchange for an
exclusive, worldwide license to market and sell LJP 394, Abbott, a diversified
health-care company, agreed to pay an initial nonrefundable license fee of
$4,000,000 upon signing, and agreed to fund the development of the Company's
lupus drug candidate, LJP 394, in accordance with a mutually agreed upon budget,
and to make certain payments to the Company upon the attainment of specific
milestones, as well as royalty and sales incentive payments to the Company on
sales of LJP 394.

Under a separate stock purchase agreement, Abbott also purchased common stock of
the Company in December 1996, September 1997 and October 1998 for an aggregate
purchase price of $4,000,000 on each date at values based on the reported last
sale price of the common stock on each of the 20 trading days immediately
preceding each purchase date. The stock purchase agreement originally allowed
Abbott certain registration rights and rights of first refusal and imposed
transfer restrictions on the shares, among other things, and allowed the Company
certain rights of first refusal and imposed certain other continuing obligations
on the Company. However, by waiver dated February 6, 2001, both Abbott and the
Company have waived any material continuing obligations of the other party under
the stock purchase agreement.

Until its termination in September 1999, the Company incurred research and
development costs under the collaborative agreement with Abbott of approximately
$4,690,000 and $8,600,000 during the years ended December 31, 1999 and 1998,
respectively, for the development of LJP 394. In 1999, the Company


                                      F-10
   48

                         La Jolla Pharmaceutical Company

                          Notes to Financial Statements

2. COLLABORATIVE AGREEMENTS (CONTINUED)

recorded revenue of $4,690,000 from Abbott for the development of LJP 394, of
which $2,921,000 was received in cash in 1999 and $1,769,000 was revenue
recognized from previously deferred revenue. In 1998, the Company received
$9,077,000 from Abbott for the development of LJP 394, of which $8,600,000 was
recorded as revenue.

3. RESTRUCTURING CHARGES

As a result of the termination of the Company's collaborative agreement with
Abbott in September 1999, the Company restructured its operations in order to
reduce expenses and to focus its resources on its remaining potential drug
candidates. In September 1999, the Company recorded estimated restructuring
charges of approximately $742,000. When the restructuring was completed in
December 1999, actual total restructuring expenses paid and charged against the
restructuring liability were approximately $640,000 and approximately $108,000
of the estimated liability was reversed in November and December 1999. Total
restructuring expenses paid consisted of termination benefits paid to 38
employees terminated from various company departments, and are included in both
research and development and general and administrative expense. There were no
material changes to the restructuring liability subsequent to December 31, 1999.

4. CASH EQUIVALENTS AND SHORT-TERM INVESTMENTS

The following is a summary of available-for-sale securities (in thousands):



                                                                            GROSS       GROSS
                                                                          UNREALIZED  UNREALIZED    ESTIMATED
                                                           ADJUSTED COST    GAINS       LOSSES     FAIR VALUE
                                                           --------------------------------------------------
                                                                                       
DECEMBER 31, 2000
Money market accounts                                         $ 1,093      $    --      $    --      $ 1,093
United States corporate debt securities                        31,344          121           36       31,429
Government-asset-backed securities                              4,968           14           --        4,982
United States Treasury securities and
    obligations of the United States
    government agencies                                         1,023            6           --        1,029
                                                              ----------------------------------------------
                                                              $38,428      $   141      $    36      $38,533
                                                              ==============================================

DECEMBER 31, 1999
Money market accounts                                         $   570      $    --      $    --      $   570
United States corporate debt securities                         4,899           --           --        4,899
Government-asset-backed securities                              4,500           --           --        4,500
                                                              ----------------------------------------------
                                                              $ 9,969      $    --      $    --      $ 9,969
                                                              ==============================================


The net adjustment to unrealized holding gains (losses) on available-for-sale
securities included in comprehensive income totaled $105,000 in 2000. Included
in cash and cash equivalents at December 31, 2000 and 1999 were $6,695,000 and
$2,975,000, respectively, of securities classified as available-for-


                                      F-11
   49

                         La Jolla Pharmaceutical Company

                          Notes to Financial Statements


4. CASH EQUIVALENTS AND SHORT-TERM INVESTMENTS (CONTINUED)

sale. As of December 31, 2000, available-for-sale securities of $30,457,000
mature in one year or less and $8,076,000 are due after one year through two
years.

5. COMMITMENTS

LEASES

In July 1992, the Company entered into a non-cancellable operating lease for the
rental of its office and research and development facilities, which expires in
July 2004. The lease is subject to an escalation clause that provides for annual
increases based on the Consumer Price Index. The lease also contains an option
to extend the lease term for an additional five years and a one-time
cancellation option effective any time after August 1, 1998 with the payment of
certain penalties.

In October 1996, the Company entered into a non-cancellable operating lease for
the rental of office and research and development facilities, which expires in
October 2001. The lease contains a provision for scheduled annual rent increases
and an option to extend the lease term for an additional five years.

The Company leases certain other equipment and leasehold improvements under
operating leases. As of December 31, 2000, the total amount of equipment and
leasehold improvements financed under these operating leases was $6,245,000.

Annual future minimum lease payments as of December 31, 2000, are as follows (in
thousands):



                                             OPERATING       CAPITAL
YEARS ENDED DECEMBER 31,                      LEASES         LEASES
- --------------------------------------------------------------------
                                                       
2001                                         $ 2,319          $ 44
2002                                           1,284            --
2003                                             791            --
2004                                             447            --
2005                                              14            --
                                             ---------------------
Total                                        $ 4,855            44
                                             =======
Less amount representing interest                              (--)
                                                              ----
Present value of net minimum lease payments                     44
Less current portion                                           (44)
                                                              ----
Noncurrent portion of capital lease obligations               $ --
                                                              ====


Rent expense under all operating leases totaled $2,776,000, $2,360,000, and
$2,179,000 for the years ended December 31, 2000, 1999 and 1998, respectively.
Equipment acquired under capital leases included in property and equipment
totaled $36,000 and $233,000 (net of accumulated amortization of $293,000 and
$331,000) at December 31, 2000 and 1999, respectively.


                                      F-12
   50

6. STOCKHOLDERS' EQUITY

PREFERRED STOCK

As of December 31, 2000, the Company is authorized to issue 8,000,000 shares of
preferred stock with a par value of $0.01 per share, in one or more series.

The Board of Directors has designated 75,000 of preferred stock as nonredeemable
Series A Junior Participating Preferred Stock ("Series A Preferred Stock"). In
the event of liquidation, each share of Series A Preferred Stock is entitled to
receive a preferential liquidation payment of $1,000 per share plus the amount
of accrued unpaid dividends. The Series A Preferred Stock is subject to certain
anti-dilution adjustments, and the holder of each share is entitled to 1,000
votes, subject to adjustments. Cumulative quarterly dividends of the greater of
$0.25 or, subject to certain adjustments, 1,000 times any dividend declared on
shares of common stock, are payable when, as and if declared by the Board of
Directors, from funds legally available for this purpose.

WARRANTS

In connection with the Company's initial public offering in June 1994, including
the conversion of the principal and accrued interest on stockholder bridge
notes, the Company issued a total of 4,250,214 warrants . The warrant holders
were entitled to purchase one-half of one share of common stock for each warrant
at an exercise price ranging from $3.00-$5.00 per one-half share. During 2000,
warrants to purchase 4,000 shares of common stock were exercised and the
remaining warrants expired on June 3, 2000.

There are no future performance obligations, or any stated or unstated rights or
privileges associated with the issuance of the above warrants.

STOCK OPTION PLANS

In May 1989, the Company adopted the 1989 Stock Option Plan and the 1989
Nonstatutory Stock Option Plan (the "1989 Plan"), under which 904,000 shares of
common stock have been authorized for issuance upon exercise of options granted
by the Company. The 1989 Plan expired in 1999.

In June 1994, the Company adopted the 1994 Stock Incentive Plan (the "1994
Plan"), under which 3,500,000 shares of common stock have been authorized for
issuance upon exercise of options granted by the Company. The 1994 Plan provides
for the grant of incentive and non-qualified stock options, as well as other
stock-based awards, to employees, consultants and advisors of the Company with
various vesting periods as determined by the compensation committee, as well as
automatic fixed grants to non-employee directors of the Company.


                                      F-13
   51

                         La Jolla Pharmaceutical Company

                          Notes to Financial Statements

6. STOCKHOLDERS' EQUITY (CONTINUED)

A summary of the Company's stock option activity and related data follows:



                                                              OUTSTANDING OPTIONS
                                                          --------------------------
                                           OPTIONS                       WEIGHTED-
                                          AVAILABLE       NUMBER OF       AVERAGE
                                          FOR GRANT        SHARES     EXERCISE PRICE
                                         -------------------------------------------
                                                             
Balance at December 31, 1997               570,943        1,963,063       $3.25
      Granted                             (723,800)         723,800       $3.54
      Exercised                                 --         (364,903)      $1.06
      Cancelled                            388,192         (388,192)      $3.37
                                         --------------------------
Balance at December 31, 1998               235,335        1,933,768       $3.75
      Additional shares authorized         750,000               --          --
      Expired                             (225,743)              --       $1.00
      Granted                             (905,206)         905,206       $0.64
      Exercised                                 --          (19,919)      $1.49
      Cancelled                            559,204         (559,204)      $3.89
                                         --------------------------
Balance at December 31, 1999               413,590        2,259,851       $2.49
      Additional shares authorized       1,000,000               --          --
      Expired                               (7,988)              --       $1.00
      Granted                           (1,081,544)       1,081,544       $5.28
      Exercised                                 --         (159,170)      $1.34
      Cancelled                             66,688          (66,688)      $4.48
                                         --------------------------
Balance at December 31, 2000               390,746        3,115,537       $3.47
                                         ==========================





                                                                      YEARS ENDED DECEMBER 31,
                                                  2000                          1999                            1998
                                        -----------------------------------------------------------------------------------------
                                                        WEIGHTED-                      WEIGHTED-                        WEIGHTED-
                                                        AVERAGE                        AVERAGE                          AVERAGE
                                                        EXERCISE                       EXERCISE                         EXERCISE
                                         OPTIONS         PRICE         OPTIONS          PRICE          OPTIONS           PRICE
                                        ------------------------      -------------------------        --------------------------
                                                                                                      
Exercisable at end of year              2,121,134        $2.62        1,660,777         $2.43          879,502           $3.55

Weighted-average fair value of options
granted during the year                     $4.18                         $0.52                          $1.62



                                      F-14
   52

                         La Jolla Pharmaceutical Company

                          Notes to Financial Statements

6. STOCKHOLDERS' EQUITY (CONTINUED)

Exercise prices and weighted-average remaining contractual lives for the options
outstanding as of December 31, 2000 follow:



                                      WEIGHTED-
                                       AVERAGE         WEIGHTED-                             WEIGHTED-
                                      REMAINING        AVERAGE                               AVERAGE
    OPTIONS          RANGE OF        CONTRACTUAL       EXERCISE            OPTIONS           EXERCISE
  OUTSTANDING     EXERCISE PRICES        LIFE           PRICE            EXERCISABLE          PRICE
- ------------------------------------------------------------------------------------------------------
                                                                              
    115,437           $0.34              8.84            $0.34              103,012           $0.34
    614,910           $0.48              8.74            $0.48              531,951           $0.48
    520,985       $1.00 - $3.50          6.26            $1.97              453,307           $1.86
    552,285       $3.56 - $3.69          8.27            $3.64              415,149           $3.64
    603,720       $3.75 - $5.03          6.43            $4.33              481,140           $4.37
    708,200       $5.13 - $12.06         8.83            $6.83              136,575           $5.86
- -----------                                                               ---------
  3,115,537       $0.34 - $12.06         7.82            $3.47            2,121,134           $2.62
===========                                                               =========


At December 31, 2000, the Company has reserved 3,506,283 shares of common stock
for future issuance under the 1989 and 1994 Plans.

EMPLOYEE STOCK PURCHASE PLAN

Effective August 1, 1995, the Company adopted the 1995 Employee Stock Purchase
Plan, as amended (the "Purchase Plan"). Under the amended Purchase Plan, a total
of 500,000 shares of common stock are reserved for sale to employees, as
defined. Employees may purchase common stock under the Purchase Plan every three
months (up to but not exceeding 10% of each employee's earnings) over the
offering period at 85% of the fair market value of the common stock at certain
specified dates. The offering period may not exceed 24 months. For the year
ended December 31, 2000, 185,755 shares of common stock had been issued under
the Purchase Plan (78,202 shares for the year ended December 31, 1999). To date,
375,648 shares of common stock have been issued under the Purchase Plan and
124,352 shares of common stock are available for issuance.




                                                               YEARS ENDED DECEMBER 31,
                                                        2000             1999            1998
                                                    -----------       ----------      ----------
                                                                             
Weighted-average fair value of employee stock
purchase plan purchases                                $2.70             $0.91           $1.54



                                      F-15
   53

                         La Jolla Pharmaceutical Company

                          Notes to Financial Statements

6. STOCKHOLDERS' EQUITY (CONTINUED)

STOCK-BASED COMPENSATION

Pro forma information regarding net loss and net loss per share is required by
SFAS 123, which also requires that the information be determined as if the
Company has accounted for its employee stock plans granted after December 31,
1994 under the fair value method of that statement. The fair value was estimated
at the date of grant using a Black-Scholes option pricing model with the
following weighted-average assumptions for 2000, 1999 and 1998, respectively:
risk-free interest rate of 5.6%, 6.8% and 4.8%; volatility factor of the
expected market price of the Company's common stock of 1.113, 1.09 and 0.60; a
weighted-average expected life of 4.5 years for 2000 and 5 years for 1999 and
1998 and a dividend yield of 0% for all three years presented.

The Black-Scholes option valuation model was developed for use in estimating the
fair value of traded options which have no vesting restrictions and are fully
transferable. In addition, option valuation models require the input of highly
subjective assumptions including the expected stock price volatility. Because
the Company's employee stock options have characteristics significantly
different from those of traded options and because changes in the subjective
input assumptions can materially affect the fair value estimate, in management's
opinion the existing models do not necessarily provide a reliable single measure
of the fair value of its employee stock options.

For purposes of pro forma disclosures, the estimated fair value of the options
is amortized to expense over the options' vesting period. The Company's pro
forma information follows (in thousands except for net loss per share
information):



                                                                YEARS ENDED DECEMBER 31,
                                                  ---------------------------------------------------
                                                     2000                1999                  1998
                                                  ---------------------------------------------------
                                                                                   
Pro forma net loss                                $ (15,423)           $ (9,985)            $ (8,500)
                                                  ===================================================

Pro forma basic and diluted net loss per share    $   (0.59)           $  (0.50)            $  (0.46)
                                                  ===================================================


The effects of applying SFAS 123 for either recognizing compensation expense or
providing pro forma disclosures are not likely to be representative of the
effects on reported net loss for future years.

STOCKHOLDER RIGHTS PLAN

The Company has adopted a Stockholder Rights Plan (the "Rights Plan") which was
amended in July 2000. The Rights Plan provides for a dividend of one right (a
"Right") to purchase fractions of shares of the Company's Series A Preferred
Stock for each share of the Company's common stock. Under certain conditions
involving an acquisition by any person or group of 15% or more of the common
stock (or in the case of State of Wisconsin Investment Board, 20% or more), the
Rights permit the holders (other than the 15% holder, or in the case of State of
Wisconsin Investment Board, 20% holder) to purchase the Company's common stock
at a 50% discount upon payment of an exercise price of $30 per Right. In
addition, in the event of certain business combinations, the Rights permit the
purchase of the common stock of an acquirer at a 50% discount. Under certain
conditions, the Rights may be redeemed by the


                                      F-16
   54

                         La Jolla Pharmaceutical Company

                          Notes to Financial Statements


6. STOCKHOLDERS' EQUITY (CONTINUED)

Board of Directors in whole, but not in part, at a price of $.001 per Right. The
Rights have no voting privileges and are attached to and automatically trade
with the Company's common stock. The Rights expire on December 2, 2008.

7. 401(k) PLAN

The Company has established a 401(k) defined contribution retirement plan (the
"401(k) Plan"), which was amended in May 1999 to cover all employees. The 401(k)
Plan provides for voluntary employee contributions up to 20% of annual
compensation (as defined). The Company does not match employee contributions or
otherwise contribute to the 401(k) Plan.

8. INCOME TAXES

At December 31, 2000, the Company had federal and California income tax net
operating loss carryforwards of approximately $81,936,000 and $13,635,000,
respectively. The difference between the federal and California tax loss
carryforwards is primarily attributable to the capitalization of research and
development expenses for California income tax purposes and the 50% percent
limitation on California loss carryforwards. The Company also had federal and
California research tax credit carryforwards of approximately $3,940,000 and
$1,974,000, respectively. The federal net operating loss and tax credit
carryforwards will begin to expire in 2004 unless previously utilized. A portion
of the California net operating loss carryforwards totaling approximately
$231,000 expired in 2000, and will continue to expire in 2001.

Pursuant to Sections 382 and 383 of the Internal Revenue Code, annual use of the
Company's net operating loss and credit carryforwards may be limited if a
cumulative change in ownership of more than 50% occurs within a three-year
period.

Significant components of the Company's deferred tax assets are shown below (in
thousands):



                                                        DECEMBER 31,
                                                 -----------------------
                                                     2000           1999
                                                 -----------------------
                                                          
Deferred tax assets:
   Net operating loss carryforwards              $ 29,462       $ 24,553
   Research and development credits                 5,223          4,017
   Capitalized research and development             3,760          3,493
                                                 -----------------------
Total deferred tax assets                          38,445         32,063
Deferred tax liability                               (152)           (61)
                                                 -----------------------
                                                   38,293         32,002
Valuation allowance for deferred tax assets       (38,293)       (32,002)
                                                 -----------------------
Net deferred tax assets                          $     --        $    --
                                                 =======================


A valuation allowance of $38,293,000 has been recognized to offset the deferred
tax assets as realization of such assets is uncertain.


                                      F-17
   55

                         La Jolla Pharmaceutical Company

                          Notes to Financial Statements

9. SUBSEQUENT EVENT

In February 2001, the Company issued 5,700,000 shares of common stock in a
private placement to selected institutional investors and other accredited
investors for gross proceeds of approximately $35,340,000 at a discounted per
share value based on the reported last sale price of the common stock on the
purchase date.




                                      F-18
   56

                                   SIGNATURES

               Pursuant to the requirements of Section 13 or 15(d) of the
Securities Exchange Act of 1934, the Registrant has duly caused this report to
be signed on its behalf by the undersigned thereunto duly authorized.

                                         LA JOLLA PHARMACEUTICAL COMPANY


                                         By:    /s/ Steven B. Engle
                                                --------------------------------
March 27, 2001                           Name:  Steven B. Engle
                                         Title: Chairman of the Board and
                                                Chief Executive Officer


               Pursuant to the requirements of the Securities Exchange Act of
1934, this report has been signed below by the following persons on behalf of
the Registrant and in the capacities and on the dates indicated.




          Signature                         Title                            Date
          ---------                         -----                            ----
                                                                    
  /s/ Steven B. Engle               Chairman of the Board and Chief       March 27, 2001
- -------------------------------     Executive Officer
Steven B. Engle                     (PRINCIPAL EXECUTIVE OFFICER
                                    AND DIRECTOR)



  /s/ Gail A. Sloan                 Controller and Secretary              March 27, 2001
- -------------------------------     (PRINCIPAL FINANCIAL AND
Gail A. Sloan                       ACCOUNTING OFFICER)



  /s/ Thomas H. Adams               Director                              March 27, 2001
- -------------------------------
Thomas H. Adams, Ph.D.

  /s/ William E. Engbers            Director                              March 27, 2001
- -------------------------------
William E. Engbers

  /s/ Robert A. Fildes              Director                              March 27, 2001
- -------------------------------
Robert A Fildes, Ph.D.

/s/ Stephen M. Martin               Director                              March 27, 2001
- -------------------------------
Stephen M. Martin

  /s/ W. Leigh Thompson             Director                              March 27, 2001
- -------------------------------
W. Leigh Thompson, M.D., Ph.D.



   57

                         La Jolla Pharmaceutical Company

                                  Exhibit Index


Exhibit Number                          Description
- --------------                          -----------

    10.20              La Jolla Pharmaceutical Company 1995 Employee Stock
                       Purchase Plan (Amended and Restated as of March 19, 2001)

    10.36              Waiver of Contractual Restrictions dated February 6, 2001

    23.1               Consent of Ernst & Young LLP, Independent Auditors

EX-10.20

   1
                                                                   EXHIBIT 10.20

                        LA JOLLA PHARMACEUTICAL COMPANY

                       1995 EMPLOYEE STOCK PURCHASE PLAN
               (AS AMENDED AND RESTATED EFFECTIVE MARCH 19, 2001)

               The following constitutes the provisions of the La Jolla
Pharmaceutical Company 1995 Employee Stock Purchase Plan (as amended and
restated effective March 19, 2001) (the "PLAN").

1.      PURPOSE.

               The purpose of the Plan is to maintain competitive equity
compensation programs and to provide employees of La Jolla Pharmaceutical
Company (the "COMPANY") with an opportunity and incentive to acquire a
proprietary interest in the Company through the purchase of the Company's Common
Stock, thereby more closely aligning the interests of the Company's employees
and stockholders. It is the intention of the Company to have the Plan qualify as
an "Employee Stock Purchase Plan" under Section 423 of the Internal Revenue Code
of 1986, as amended ("SECTION 423"). Accordingly, the provisions of the Plan
shall be construed to extend and limit participation consistent with the
requirements of Section 423.

2.      DEFINITIONS.

               Capitalized terms used in this Plan and not otherwise defined
have the meanings set forth below.

               "ADMINISTRATOR" means the Committee, or the Board if the Board
asserts administrative authority over the Plan pursuant to Section 13.

               "BOARD" means the Board of Directors of the Company.

               "CODE" means the Internal Revenue Code of 1986, as amended.

               "COMMITTEE" means a committee of members of the Board meeting the
qualifications described in Section 13 and appointed by the Board to administer
the Plan.

               "COMMON STOCK" shall mean the Common Stock of the Company.

               "COMPENSATION" means base salary or hourly compensation and any
cash bonus paid to a participant.


   2

               "ELIGIBLE EMPLOYEE" means any employee of the Company whose
customary employment is for more than five months per calendar year and for more
than 20 hours per week. For purposes of the Plan, the employment relationship
shall be treated as continuing while the individual is on sick leave or other
leave of absence approved by the Company, except that when the period of leave
exceeds 90 days and the individual's right to reemployment is not guaranteed
either by statute or by contract, the employment relationship will be deemed to
have terminated on the 91st day of such leave.

               "ENROLLMENT DATE" means the first day of each Offering Period.

               "EXCHANGE ACT" means the Securities Exchange Act of 1934, as
amended.

               "EXERCISE DATE" means the last day of each Purchase Period.

               "FAIR MARKET VALUE" of the Common Stock as of the time of any
determination thereof means the value of Common Stock determined as follows:

                      (1) If the Common Stock is listed on any established stock
exchange or trades on the Nasdaq National Market, its Fair Market Value shall be
the most recent closing sales price for such stock (or the closing bid, if no
sales were reported), as quoted on such exchange or system (or the exchange or
system with the greatest volume of trading in the Common Stock) as of the time
of such determination as reported in the Wall Street Journal or such other
source as the Administrator deems reliable; or

                      (2) If the Common Stock is not listed on any established
stock exchange or traded on the Nasdaq National Market its Fair Market Value
shall be the mean between the most recent closing high and low asked prices for
the Common Stock as of the time of such determination, as reported in the Wall
Street Journal or such other source as the Administrator deems reliable; or

                      (3) In the absence of an established market for the Common
Stock, the Fair Market Value of the Common Stock shall be determined in good
faith by the Administrator.

               "OFFERING PERIOD" means (i) the period of twenty-three (23)
months commencing on August 1, 1996 and terminating on June 30, twenty-three
(23) months later; (ii) each period of twenty-four (24) months commencing on
January 1, 1997 and each January 1 thereafter for the duration of the Plan and
terminating on the December 31 twenty-four (24) months later; (iii) each period
of twenty-four (24) months commencing on July 1, 1997 and each July 1 thereafter
for the duration of the Plan and terminating on the June 30 twenty-four (24)
months later; (iv) each period of twenty-four (24) months commencing on October
1, 2000 and each October 1 thereafter for the duration of the Plan and
terminating on the September 30 twenty-four (24) months later; and (v) each
period of twenty-four (24) months commencing on April 1, 2001 and each April 1
thereafter for the duration of the Plan and terminating on the March 31
twenty-four (24) months later. The Administrator shall have the power to change
the duration of Offering Periods without stockholder approval as set forth in
Section 12 or if such change is announced at least fifteen (15) days prior to
the scheduled beginning of the first Offering Period to be affected.

               "OPTION" means the option granted to each participant pursuant to
Section 4 upon enrollment in an Offering Period.


                                       2
   3

               "PERIODIC EXERCISE LIMIT" has the meaning set forth in Section
4(a).

               "PLAN ACCOUNT" means an account maintained by the Company for
each participant in the Plan, to which are credited the payroll deductions made
for such participant pursuant to Section 5 and from which are debited amounts
paid for the purchase of shares upon exercise of such participant's Option
pursuant to Section 6.

               "PURCHASE PRICE" as of any Exercise Date means an amount equal to
85% of the Fair Market Value of a share of Common Stock as of the close of
business on the Exercise Date or the opening of business on the Enrollment Date
for the Offering Period in which such Exercise Date occurs, whichever is lower.

               "PURCHASE PERIOD" means (i) the period of five (5) months
commencing on August 1, 1996 and ending on December 31, 1996; (ii) with respect
to the Offering Periods beginning on January and July 1, 1997, January and July
1, 1998, and January 1, 1999, each period of six (6) months within any such
Offering Period, commencing January 1, 1997 and each July 1 and January 1
thereafter, and ending on the December 31 or June 30 following such commencement
date; (iii) with respect to the Offering Period beginning on July 1, 1999, the
period of six (6) months commencing July 1, 1999 and ending on December 31,
1999, the period of six (6) months commencing on January 1, 2000 and ending on
June 30, 2000, the period of six (6) months commencing on July 1, 2000 and
ending on December 31, 2000, the period of three (3) months commencing on
January 1, 2001 and ending on March 31, 2001, and the period of three (3) months
commencing on April 1, 2001 and ending on June 30, 2001, (iv) with respect to
the Offering Period beginning on January 1, 2000, the period of six (6) months
commencing on January 1, 2000 and ending on June 30, 2000, the period of six (6)
months commencing on July 1, 2000 and ending on December 31, 2000, and each
period of three (3) months commencing on January 1, 2001 and each April 1, July
1, and October 1 thereafter, and ending on the March 31, June 30, September 30
and December 31 following such commencement date; (v) with respect to the
Offering Period beginning on July 1, 2000, the period of six (6) months
commencing on July 1, 2000 and ending on December 31, 2000, and each period of
three (3) months commencing on January 1, 2001 and each April 1, July 1, and
October 1 thereafter, and ending on the March 31, June 30, September 30 and
December 31 following such commencement date; and (vi) for any Offering Period
commencing on or after October 1, 2000, each period of three (3) months within
the Offering Period commencing on October 1, 2000 and each January 1, April 1,
July 1, and October 1 thereafter, and ending on the December 31, March 31, June
30, and September 30 following such commencement date.

               "RESERVES" means the number of shares of Common Stock covered by
each Option that has not yet been exercised and the number of shares of Common
Stock that have been authorized for issuance under the Plan, but not yet placed
under any Option.

               "RULE 16b-3" means Rule 16b-3 under the Exchange Act and any
successor provision.

               "SUBSIDIARY" has the meaning as set forth under Section 424(f) of
the Code.

               "TRADING DAY" means a day on which national stock exchanges and
the National Association of Securities Dealers Automated Quotation System are
open for trading.


                                       3
   4

3.      OFFERING PERIODS AND PARTICIPATION.

               The Plan shall be implemented through a series of consecutive and
overlapping Offering Periods. An Eligible Employee may enroll in an Offering
Period by delivering a subscription agreement in the form of Exhibit A hereto to
the Company's payroll office at least five (5) business days prior to the
Enrollment Date for that Offering Period. Eligible Employees shall participate
in only one Offering Period at a time, and a subscription agreement in effect
for a Plan participant for a particular Offering Period shall continue in effect
for subsequent Offering Periods if the participant remains an Eligible Employee
and has not withdrawn pursuant to Section 8.

4.      OPTIONS.

               (a) Grants. On the Enrollment Date for each Offering Period, each
Eligible Employee participating in such Offering Period shall be granted an
Option to purchase (i) on each Exercise Date for any six-month Purchase Period
in such Offering Period (at the applicable Purchase Price) up to that number of
shares of Common Stock determined by dividing $12,500 by the Fair Market Value
of a share of Common Stock as of the opening of business on the Enrollment Date,
and (ii) on each Exercise Date for any three-month Purchase Period in such
Offering Period (at the applicable Purchase Price) up to that number of shares
of Common Stock determined by dividing $6,250 by the Fair Market Value of a
share of Common Stock as of the opening of business on the Enrollment Date (such
number of shares being the "PERIODIC EXERCISE LIMIT"). The Option shall expire
immediately after the last Exercise Date of the Offering Period.

               (b) Grant Limitations. Any provisions of the Plan to the contrary
notwithstanding, no participant shall be granted an Option under the Plan:

                      (i) if, immediately after the grant, such participant (or
               any other person whose stock would be attributed to such
               participant pursuant to Section 424(d) of the Code) would own
               stock and/or hold outstanding options to purchase stock
               possessing five percent (5%) or more of the total combined voting
               power or value of all classes of stock of the Company or of any
               Subsidiary; or

                      (ii) which permits such participant's rights to purchase
               stock under all employee stock purchase plans of the Company and
               its Subsidiaries to accrue at a rate that exceeds Twenty-Five
               Thousand Dollars ($25,000) worth of stock (determined at the Fair
               Market Value of the shares at the time such Option is granted) in
               any calendar year.

               (c) No Rights in Respect of Underlying Stock. The participant
will have no interest or voting right in shares covered by an Option until such
Option has been exercised.

5.      PAYROLL DEDUCTIONS.

               (a) Participant Designations. The subscription agreement
applicable to an Offering Period shall designate payroll deductions to be made
on each payday during the Offering Period as a whole number percentage not
exceeding ten percent (10%) of such Eligible Employee's Compensation for the pay
period preceding such payday, provided that


                                       4
   5

the aggregate of such payroll deductions during the Offering Period shall not
exceed ten percent (10%) of the participant's Compensation during said Offering
Period.

               (b) Plan Account Balances. The Company shall make payroll
deductions as specified in each participant's subscription agreement on each
payday during the Offering Period and credit such payroll deductions to such
participant's Plan Account. A participant may not make any additional payments
into such Plan Account. No interest will accrue on any payroll deductions. All
payroll deductions received or held by the Company under the Plan may be used by
the Company for any corporate purpose, and the Company shall not be obligated to
segregate such payroll deductions.

               (c) Participant Changes. A participant may discontinue his or her
participation in the Plan as provided in Section 8, or may increase or decrease
(subject to such limits as the Administrator may impose) the rate of his or her
payroll deductions during any Purchase Period by filing with the Company a new
subscription agreement authorizing such a change in the payroll deduction rate.
The change in rate shall be effective with the first full payroll period
following five (5) business days after the Company's receipt of the new
subscription agreement, unless the Company elects to process a given change in
participation more quickly.

               (d) Decreases. Notwithstanding the foregoing, to the extent
necessary to comply with Section 423(b)(8) of the Code and Section 4(b) herein,
a participant's payroll deductions may be decreased to 0% at such time during
any Purchase Period that is scheduled to end during a calendar year (the
"CURRENT PURCHASE PERIOD") when the aggregate of all payroll deductions
previously used to purchase stock under the Plan in a prior Purchase Period
which ended during that calendar year plus all payroll deductions accumulated
with respect to the Current Purchase Period equal $21,250. Payroll deductions
shall recommence at the rate provided in such participant's subscription
agreement at the beginning of the first Purchase Period that is scheduled to end
in the following calendar year, unless terminated by the participant as provided
in Section 8.

               (e) Tax Obligations. At the time of each exercise of a
participant's Option, and at the time any Common Stock issued under the Plan to
a participant is disposed of, the participant must adequately provide for the
Company's federal, state, or other tax withholding obligations, if any, that
arise upon the exercise of the Option or the disposition of the Common Stock. At
any time, the Company may, but will not be obligated to, withhold from the
participant's compensation the amount necessary for the Company to meet
applicable withholding obligations, including any withholding required to make
available to the Company any tax deductions or benefit attributable to sale or
early disposition of Common Stock by the participant.

               (f) Statements of Account. The Company shall maintain each
participant's Plan Account and shall give each Plan participant a statement of
account at least annually. Such statements will set forth the amounts of payroll
deductions, the Purchase Price, the number of shares purchased and the remaining
cash balance, if any, for the period covered.

6.      EXERCISE OF OPTIONS.

               (a) Automatic Exercise on Exercise Dates. Unless a participant
withdraws as provided in Section 8, his or her Option for the purchase of shares
will be exercised automatically on each Exercise Date within the Offering Period
in which such


                                       5
   6

participant is enrolled for the maximum number of shares of Common Stock,
including fractional shares, as can then be purchased at the applicable Purchase
Price with the payroll deductions accumulated in such participant's Plan Account
and not yet applied to the purchase of shares under the Plan, subject to the
Periodic Exercise Limit. During a participant's lifetime, a participant's
Options to purchase shares hereunder are exercisable only by the participant.

               (b) Delivery of Shares. As promptly as practicable after each
Exercise Date on which a purchase of shares occurs, the Company shall arrange
the delivery to each participant, as appropriate, of a certificate or book entry
transfer representing the shares purchased upon exercise of his or her Option,
provided that the Company may in its discretion hold fractional shares for the
accounts of the participants pending aggregation to whole shares.

               (c) Compliance with Law. Shares shall not be issued with respect
to an Option unless the exercise of such Option and the issuance and delivery of
such shares pursuant thereto comply with all applicable provisions of law,
domestic or foreign, including, without limitation, the Securities Act of 1933,
as amended, the Exchange Act, the rules and regulations promulgated thereunder,
and the requirements of any stock exchange upon which the shares may then be
listed, and shall be further subject to the approval of counsel for the Company
with respect to such compliance. As a condition to the exercise of an Option,
the Company may require the participant for whom an Option is exercised to
represent and warrant at the time of any such exercise that the shares are being
purchased only for investment and without any present intention to sell or
distribute such shares if, in the opinion of counsel for the Company, such a
representation is required by any of the aforementioned applicable provisions of
law. Shares issued upon purchase under the Plan may be subject to such transfer
restrictions and stop-transfer instructions as the Administrator deems
appropriate.

               (d) Excess Plan Account Balances. If, due to application of the
Periodic Exercise Limit, there remains in a participant's Plan Account
immediately following exercise of such participant's Option on an Exercise Date
any cash accumulated during the Purchase Period immediately preceding such
Exercise Date and not applied to the purchase of shares under the Plan, such
cash shall promptly be returned to the participant.

7.      AUTOMATIC TRANSFER TO LOW PRICE OFFERING PERIOD.

               If the Fair Market Value of the Common Stock as of the close of
business on any Exercise Date is lower than the Fair Market Value of the Common
Stock as of the opening of business on the Enrollment Date for the Offering
Period in which such Exercise Date occurs, then all participants in such
Offering Period shall be automatically withdrawn from such Offering Period
immediately after the exercise of their Options on such Exercise Date and
automatically re-enrolled in the immediately following Offering Period as of the
first day thereof.

8.      WITHDRAWAL; TERMINATION OF EMPLOYMENT.

               (a) Voluntary Withdrawal. A participant may withdraw from an
Offering Period by giving written notice to the Company's payroll office at
least five (5) business days prior to the next Exercise Date. Such withdrawal
shall be effective beginning five business days after receipt by the Company's
payroll office of notice thereof. On or promptly following the effective date of
any withdrawal, all (but not less than all) of the withdrawing


                                       6
   7

participant's payroll deductions credited to his or her Plan Account and not yet
applied to the purchase of shares under the Plan will be paid to such
participant, and on the effective date of such withdrawal such participant's
Option for the Offering Period will be automatically terminated, and no further
payroll deductions for the purchase of shares will be made during the Offering
Period. If a participant withdraws from an Offering Period, payroll deductions
will not resume at the beginning of any succeeding Offering Period unless the
participant delivers to the Company a new subscription agreement with respect
thereto.

               (b) Termination of Employment. Promptly after a participant's
ceasing to be an Eligible Employee for any reason the payroll deductions
credited to such participant's Plan Account and not yet applied to the purchase
of shares under the Plan will be returned to such participant or, in the case of
his or her death, to the person or persons entitled thereto under Section 10,
and such participant's Option will be automatically terminated, provided that,
if the Company does not learn of such death more than five (5) business days
prior to an Exercise Date, payroll deductions credited to such participant's
Plan account may be applied to the purchase of shares under the Plan on such
Exercise Date.

9.      TRANSFERABILITY.

               Neither payroll deductions credited to a participant's Plan
Account nor any rights with regard to the exercise of an Option or to receive
shares under the Plan nor any Option itself may be assigned, transferred,
pledged or otherwise disposed of by the participant in any way other than by
will, the laws of descent and distribution or as provided in Section 10 hereof.
Any such attempt at assignment, transfer, pledge or other disposition shall be
without effect, except that the Administrator may treat such act as an election
to withdraw from an Offering Period in accordance with Section 8.

10.     DESIGNATION OF BENEFICIARY.

               A participant may file a written designation of a beneficiary who
is to receive any cash from the participant's Plan Account in the event of such
participant's death and any shares purchased for the participant upon exercise
of his or her Option but not yet issued. If a participant is married and the
designated beneficiary is not the spouse, spousal consent may be required for
such designation to be effective. A designation of beneficiary may be changed by
a participant at any time by written notice. In the event of the death of a
participant and in the absence of a beneficiary validly designated under the
Plan who is living at the time of such participant's death, the Company shall
deliver such shares and/or cash to the executor or administrator of the estate
of the participant, or if no such executor or administrator has been appointed
(to the knowledge of the Company), the Company, in its discretion, may deliver
such shares and/or cash to the spouse or to any one or more dependents or
relatives of the participant, or if no spouse, dependent or relative is known to
the Company, then to such other person as the Company may designate.

11.     STOCK.

               The maximum number of shares of the Company's Common Stock that
shall be made available for sale under the Plan shall be 500,000 shares, subject
to adjustment upon changes in capitalization of the Company as provided in
Section 12. If on a given Enrollment Date or Exercise Date the number of shares
with respect to which Options are to be granted or exercised exceeds the number
of shares then available under the Plan, the Administrator shall make a pro rata
allocation of the shares remaining available for purchase in as uniform a manner
as shall be practicable and as it shall determine to be equitable.


                                       7
   8

Shares of Common Stock subject to unexercised Options that expire, terminate or
are cancelled will again become available for the grant of further Options under
the Plan.

12.     ADJUSTMENTS UPON CHANGES IN CAPITALIZATION, DISSOLUTION, MERGER OR ASSET
        SALE.

               (a) Changes in Capitalization. Subject to any required action by
the stockholders of the Company, the Reserves as well as the Purchase Price,
Periodic Exercise Limit, and other characteristics of the Options, shall be
appropriately and proportionately adjusted for any increase or decrease or
exchange in the issued shares of Common Stock resulting from a stock split,
reverse stock split, stock dividend, combination or reclassification of the
Common Stock, exchange or any other increase or decrease in the number of shares
of Common Stock effected without receipt of consideration by the Company;
provided, however, that conversion of any convertible securities of the Company
shall not be deemed to have been "effected without receipt of consideration."
Such adjustment shall be made by the Administrator, whose determination in that
respect shall be final, binding and conclusive. Except as expressly provided
herein, no issuance by the Company of shares of stock of any class, or
securities convertible into shares of stock of any class, shall affect, and no
adjustment by reason thereof shall be made with respect to, the number or price
of shares of Common Stock subject to an Option. The Administrator may, if it so
determines in the exercise of its sole discretion, provide for adjusting the
Reserves, as well as the Purchase Price, Periodic Exercise Limit, and other
characteristics of the Options, in the event the Company effects one or more
reorganizations, recapitalizations, rights offerings or other increases or
reductions of shares of its outstanding Common Stock.

               (b) Dissolution or Liquidation. In the event of the proposed
dissolution or liquidation of the Company, all pending Offering Periods will
terminate immediately prior to the consummation of such proposed action, unless
otherwise provided by the Administrator, and all Plan Account balances will be
paid to participants as appropriate consistent with applicable law.

               (c) Merger or Asset Sale. In the event of a proposed sale of all
or substantially all of the assets of the Company, or the merger or other
combination (the "Transaction") of the Company with or into another entity, each
Option under the Plan shall be assumed or an equivalent option shall be
substituted by such successor entity or a parent or subsidiary of such successor
entity, unless the Administrator determines, in the exercise of its sole
discretion and in lieu of such assumption or substitution, to shorten the
Offering Periods then in progress by setting a new Exercise Date (the "NEW
EXERCISE DATE"). If the Administrator shortens the Offering Periods then in
progress in lieu of assumption or substitution, the Administrator shall notify
each participant in writing, at least ten (10) days prior to the New Exercise
Date, that the Exercise Date for such participant's Option has been changed to
the New Exercise Date and that such participant's Option will be exercised
automatically on the New Exercise Date, unless prior to such date the
participant has withdrawn from the Offering Period as provided in Section 8
(provided that, in such case, the participant's withdrawal shall be effective if
notice thereof is delivered to the Company's payroll office at least two (2)
business days prior to the New Exercise Date). For purposes of this Section, an
Option granted under the Plan shall be deemed to be assumed if, following the
Transaction the Option confers the right to purchase at the Purchase Price
(provided that for such purposes the Fair Market Value of the Common Stock on
the New Exercise Date shall be the value per share of the consideration paid in
the Transaction), for each share of stock subject to the Option immediately
prior to the Transaction, the consideration (whether stock, cash or other
securities or property) received in the Transaction by holders of


                                       8
   9

Common Stock for each share of Common Stock held on the effective date of the
transaction (and if such holders were offered a choice of consideration, the
type of consideration chosen by the holders of a majority of the outstanding
shares of Common Stock); provided, however, that if such consideration received
in the Transaction was not solely common equity of the successor entity or its
parent (as defined in Section 424(e) of the Code), the Administrator may, with
the consent of the successor entity and the participant, provide for the
consideration to be received upon exercise of the Option to be solely common
equity of the successor entity or its parent equal in fair market value to the
per share consideration received by holders of Common Stock in the Transaction.

13.     ADMINISTRATION.

               The Plan shall be administered by the Committee, which shall have
the authority to construe, interpret and apply the terms of the Plan and any
agreements defining the rights and obligations of the Company and participants
under the Plan, to prescribe, amend, and rescind rules and regulations relating
to the Plan, to determine eligibility and to adjudicate all disputed claims
filed under the Plan, and to make all other determinations necessary or
advisable for the administration of the Plan. The Administrator may, in its
discretion, delegate ministerial responsibilities under the Plan to the Company.
Every finding, decision and determination made by the Committee shall, to the
full extent permitted by law, be final and binding upon all parties. Any action
of the Committee shall be taken pursuant to a majority vote or by the unanimous
written consent of its members. The Committee shall consist of three or more
members of the Board, each of whom shall be disinterested within the meaning of
Rule 16b-3, provided, however, that the number of members of the Committee may
be reduced or increased from time to time by the Board to the number required or
allowed by Rule 16b-3. The Board may from time to time in its discretion
exercise any responsibilities or authority allocated to the Committee under the
Plan. No member of the Committee or any designee thereof will be liable for any
action or determination made in good faith with respect to the Plan or any
transaction arising under the Plan.

14.     AMENDMENT OR TERMINATION.

               (a) Administrator's Discretion. The Administrator may, at any
time and for any reason, terminate or amend the Plan. Except as provided in
Section 12, no such termination can affect Options previously granted, provided
that an Offering Period may be terminated by the Administrator on any Exercise
Date if the Administrator determines that such termination is in the best
interests of the Company and its stockholders. Except as provided herein, no
amendment may make any change in any Option theretofore granted that adversely
affects the rights of any participant. To the extent necessary to comply with
and qualify under Rule 16b-3 or under Section 423 (or any successor rule or
provision or any other applicable law or regulation), the Administrator shall
obtain stockholder approval of amendments to the Plan in such a manner and to
such a degree as required.

               (b) Administrative Modifications. Without stockholder consent
(except as specifically required by applicable law or regulation) and without
regard to whether any participant rights may be considered to have been
"adversely affected," the Administrator shall be entitled to amend the Plan to
the extent necessary to comply with and qualify under Rule 16b-3 and Section
423, change the Purchase Periods and/or Offering Periods, limit the frequency
and/or number of changes in payroll deductions during Purchase Periods and/or
Offering Periods, establish the exchange ratio applicable to amounts withheld in
a currency other than U.S. dollars, permit payroll withholding in excess of the
amount designated by a


                                       9
   10

participant to adjust for delays or mistakes in the Company's processing of
properly completed withholding elections, establish reasonable waiting and
adjustment periods and/or accounting and crediting procedures to ensure that
amounts applied toward the purchase of Common Stock for each participant
properly correspond with amounts withheld from the participant's Compensation,
and establish such other limitations or procedures as the Administrator
determines in its sole discretion to be advisable and which are consistent with
the Plan.

15.     TERM OF PLAN.

               The Plan shall become effective upon the first Enrollment Date
after its approval by the stockholders of the Company and shall continue in
effect for a term of twenty (20) years unless sooner terminated pursuant to
Section 14.

16.     MISCELLANEOUS.

               (a) Notices. All notices or other communications by a participant
to the Company under or in connection with the Plan shall be deemed to have been
duly given when received in the form specified by the Company at the location,
or by the person, designated by the Company for the receipt thereof.

               (b) Subsidiaries. The Administrator may from time to time in its
discretion permit persons who are employees of any Subsidiary whose customary
employment is for more than five months per calendar year and for more than 20
hours per week to participate in the Plan on the same terms as Eligible
Employees hereunder.

               (c) Stockholder Approval. The Plan shall be subject to approval
by the stockholders of the Company within twelve months before or after the date
the Board adopts the Plan. If such stockholder approval is not obtained, the
Plan and all rights to the Common Stock purchased under the Plan shall be null
and void and shall have no effect.

               (d) Additional Restrictions of Rule 16b-3. The terms and
conditions of Options granted hereunder to, and the purchase of shares by,
persons subject to Section 16 of the Exchange Act shall comply with the
applicable provisions of Rule 16b-3. This Plan shall be deemed to contain, and
such Options shall contain, and the shares issued upon exercise thereof shall be
subject to, such additional conditions and restrictions as may be required by
Rule 16b-3 to qualify for the maximum exemption from Section 16 of the Exchange
Act with respect to Plan transactions.

               (e) No Employment Rights. The Plan does not, directly or
indirectly, create any right for the benefit of an employee or class of
employees to purchase any shares under the Plan, or create in any employee or
class of employees any right with respect to continuation of employment by the
Company, and it shall not be deemed to interfere in any way with the Company's
right to terminate, or otherwise modify, an employee's employment at any time.

               (f) Applicable Law. The laws of the State of California shall
govern all matters relating to the Plan, except to the extent (if any)
superseded by the laws of the United States.

               (g) Headings. Headings used herein are for convenience of
reference only and do not affect the meaning or interpretation of the Plan.


                                       10
   11

                                    EXHIBIT A

                         LA JOLLA PHARMACEUTICAL COMPANY
                        1995 EMPLOYEE STOCK PURCHASE PLAN
                             SUBSCRIPTION AGREEMENT

_____ Original Application                         Enrollment Date: ___________
_____ Change in Payroll Deduction Rate
_____ Change of Beneficiary(ies)

1.      I, ________________________, hereby elect to participate in the La Jolla
        Pharmaceutical Company 1995 Employee Stock Purchase Plan (the "Plan")
        and subscribe to purchase shares of the Company's Common Stock in
        accordance with this Subscription Agreement and the Plan.

2.      I hereby authorize payroll deductions from each paycheck in the amount
        of ____% (not to exceed 10%) of my Compensation (as defined in the Plan)
        on each payday during the Offering Period in accordance with the Plan.
        (Please note that no fractional percentages are permitted.)

3.      I understand that said payroll deductions shall be accumulated for the
        purchase of shares of Common Stock at the applicable Purchase Price
        determined in accordance with the Plan. I understand that if I do not
        withdraw from an Offering Period, any accumulated payroll deductions
        will be used to automatically exercise my Option on each Exercise Date
        within the Offering Period.

4.      I have received a copy of the complete Plan. I understand that my
        participation in the Plan is in all respects subject to the terms of the
        Plan, that capitalized terms used herein have the same meanings as
        ascribed thereto in the Plan, and that in case of any inconsistency
        between this Subscription Agreement and the Plan, the Plan shall govern.
        I understand that the grant of the Option by the Company under this
        Subscription Agreement is subject to stockholder approval of the Plan.

5.      Shares purchased for me under the Plan should be issued in the name(s)
        of (employee and/or spouse only):__________________________
        _______________________________________________________.

6.      I understand that if I dispose of any shares received by me pursuant to
        the Plan within two years after the Enrollment Date (the first day of
        the Offering Period during which I purchased such shares) or within one
        year after the Exercise Date (the date I purchased such shares), I will
        be treated for federal income tax purposes as having received ordinary
        income at the time of such disposition in an amount equal to the excess
        of the fair market value of the shares at the time such shares were
        delivered to me over the price which I paid for the shares, regardless
        of whether I disposed of the shares at a price less than their fair
        market value at the Exercise Date. The remainder of the gain or loss, if
        any, recognized on such disposition will be treated as capital gain or
        loss. I hereby agree to notify the Company in writing within 30 days
        after the date of any disposition of my shares, and I will make adequate
        provision for Federal, State or other tax withholding obligations, if
        any, which arise upon the disposition of the Common Stock. The Company
        may, but will not be obligated to, withhold from my Compensation or
        other amounts payable to me the amount necessary to meet any


   12

        applicable withholding obligation including any withholding necessary to
        make available to the Company any tax deductions or benefits
        attributable to sale or early disposition of Common Stock by me. If I
        dispose of such shares at any time after the expiration of the one-year
        and two-year holding periods described above, I understand that I will
        be treated for federal income tax purposes as having received income
        only at the time of such disposition, and that such income will be taxed
        as ordinary income only to the extent of an amount equal to the lesser
        of (a) the excess of the fair market value of the shares at the time of
        such disposition over the purchase price which I paid for the shares, or
        (b) 15% of the fair market value of the shares on the first day of the
        Offering Period. The remainder of the gain or loss, if any, recognized
        on such disposition will be taxed as capital gain or loss. I understand
        that this tax summary is only a summary for general information purposes
        and is subject to change and I agree to consult with my own tax advisors
        for definitive advice regarding the tax consequences to me of
        participation in the Plan and sale of shares purchased thereunder.

7.      I agree to be bound by the terms of the Plan. The effectiveness of this
        Subscription Agreement is dependent upon my eligibility to participate
        in the Plan.

8.      In the event of my death, I hereby designate the following as my
        beneficiary(ies) to receive (in proportion to the percentages listed
        below) all payments and shares due me under the Plan (use additional
        sheets to add beneficiaries):

        NAME: (Please print) __________________________________________________
                               (First)             (Middle)               (Last)

        ______________________________      ___________________________________
        Relationship

        Percentage:  __________             ___________________________________
                                                   (Address)

        NAME: (Please print) __________________________________________________
                               (First)             (Middle)               (Last)

        ______________________________      ___________________________________
        Relationship

        Percentage:  __________             ___________________________________
                                                   (Address)

Employee's Social
Security Number:                            ___________________________________
Employee's Address:                         ___________________________________
                                            ___________________________________
                                            ___________________________________

I UNDERSTAND THAT THIS SUBSCRIPTION AGREEMENT SHALL REMAIN IN EFFECT THROUGHOUT
SUCCESSIVE OFFERING PERIODS UNLESS TERMINATED BY ME.


                                       2
   13


Dated: ___________________                  ___________________________________
                                            Signature of Employee

                                            ___________________________________
                                            Spouse's Signature (If beneficiary
                                            other than spouse)






                                       3

EX-10.36

   1
                                                                   EXHIBIT 10.36

                       WAIVER OF CONTRACTUAL RESTRICTIONS

        This Waiver (this "Waiver") is entered into on February 6, 2001 by and
between La Jolla Pharmaceutical Company ("LJP") and Abbott Laboratories
("Abbott").

                                    RECITALS

        WHEREAS, LJP and Abbott entered into that certain Stock Purchase
Agreement, dated December 23, 1996 (the "Agreement");

        WHEREAS, Abbott acquired certain shares of common stock of LJP (the
"Shares") under the Agreement;

        WHEREAS, Abbott desires to sell the Shares from time to time without the
restrictions currently imposed by the Agreement; and

        WHEREAS, Abbott and LJP mutually desire to terminate certain rights that
each has under the Agreement.

        NOW, THEREFORE, in consideration of the representations, warranties and
covenants herein contained, the parties hereto hereby agree as follows:

                                   AGREEMENT

        1. Waiver of LJP. LJP hereby fully, finally and irrevocably waives the
following:

           (a) the restrictions on transfer contained in Section 5(b) of the
Agreement;

           (b) its right of first refusal contained in Section 5(c) of the
Agreement; and

           (c) Abbott's obligation to cause certain subsequent purchasers of the
Shares to be bound by the terms of the Agreement contained in Section 5(e) of
the Agreement.

        2. Reliance by Abbott. LJP agrees that Abbott may rely on this Waiver in
disposing of the Shares without regard to the sale and transfer restrictions
contained in the Agreement and without offering LJP the opportunity to purchase
the Shares, as previously required by the Agreement. Notwithstanding the
foregoing, if and to the extent that it is reasonably practicable, Abbott will
give LJP 48 hours written notice prior to selling a significant amount of its
Shares.

        3. Waiver of Abbott. Abbott hereby fully, finally and irrevocably waives
the following:

           (a) its right to receive reports that LJP periodically files with the
Securities and Exchange Commission contained in Section 5(a) of the Agreement;

           (b) LJP's Nasdaq obligations contained in Section 5(f) of the
Agreement;



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           (c) its right of first refusal on new issuances of securities of the
LJP contained in Section 5(h) of the Agreement; and

           (d) its rights contained in Section 6 of the Agreement, including,
without limitation, its demand registration rights under Section 6(a) of the
Agreement, if any currently exist, and its incidental registration rights under
Section 6(c) of the Agreement.

        4. Release of Abbott. LJP, for itself and its agents, successors and
assigns, does hereby forever release and discharge Abbott, and any of its past
or present agents, employees, officers, directors, attorneys from causes of
action, losses, promises, damages, costs, expenses, liabilities and demands of
whatsoever character, nature and kind, known or unknown, suspected or
unsuspected, fixed or contingent, arising out of or in any way related to the
actions, conduct, omissions or events related to or arising out of this Waiver.

        5. Release of the LJP. Abbott, for itself and its agents, successors and
assigns, does hereby forever release and discharge LJP, and any of its past or
present agents, employees, officers, directors, attorneys from causes of action,
losses, promises, damages, costs, expenses, liabilities and demands of
whatsoever character, nature and kind, known or unknown, suspected or
unsuspected, fixed or contingent, arising out of or in any way related to the
actions, conduct, omissions or events related to or arising out of this Waiver.

        6. Waiver of Section 1542 of the Civil Code. The parties specifically
understand, acknowledge and agree that the releases enumerated in Sections 4 and
5 of this Waiver are a full and final releases, which shall be effective as a
bar to all actions, claims, counterclaims, obligations, causes of action,
losses, promises, damages, costs, expenses, liabilities and demands of
whatsoever character, nature and kind, known and unknown, suspected or
unsuspected, fixed or contingent, hereinabove specified to be so barred. The
parties, having been fully advised by their respective counsel, hereby expressly
and voluntarily waive all rights or benefits that they and each of them might
otherwise have under the provisions of Section 1542 of the Civil Code of the
State of California, which provides as follows, and under all federal, state
and/or common law statutes or principles of similar effect:

           A general release does not extend to claims which the creditor does
           not know or suspect to exist in his favor at the time of executing
           the release, which if known by him must have materially affected his
           settlement with the debtor.

        7. Counterparts. This Waiver may be executed in any number of
counterparts, each of which will be deemed an original, but all of which
together will constitute one instrument, and signatures transmitted
electronically or by facsimile will be deemed original signatures.



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        IN, WITNESS WHEREOF, LJP and Abbott each have caused this Waiver to be
executed by a duly authorized officer as of the date first written above


                                   LA JOLLA PHARMACEUTICAL COMPANY:


                                   /s/ Steven B. Engle
                                   -------------------------------
                                   Steven B. Engle,
                                   Chief Executive Officer



                                   ABBOTT LABORATORIES:


                                   /s/ GW Linder
                                   -------------------------------
                                   Greg W. Linder
                                   Vice President and Treasurer



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EX-23.1

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                                                                    EXHIBIT 23.1

                         La Jolla Pharmaceutical Company



               CONSENT OF ERNST & YOUNG LLP, INDEPENDENT AUDITORS



We consent to the incorporation by reference in the Registration Statements on
Form S-8 (No. 333-45080) pertaining to the 1994 Stock Incentive Plan and the
1995 Employee Stock Purchase Plan and in the Registration Statements on Form
S-3( Nos. 333-43066, 333-31142 and 333-55370) of La Jolla Pharmaceutical Company
of our report dated February 8, 2001, with respect to the financial statements
of La Jolla Pharmaceutical Company included in its Annual Report (Form 10-K) for
the year ended December 31, 2000.


                                                 ERNST & YOUNG LLP




San Diego, California
March 27, 2001