Accounts Payable and Accrued Expenses (Details) - USD ($) $ in Thousands	Mar. 31, 2018	Dec. 31, 2017
Accounts Payable and Accrued Expenses
Accrued research payables	$ 63,120	$ 51,275
Accrued compensation and benefits	12,808	37,911
Settlement costs payable	18,000
Accrued rent	14,040	14,821
Trade payables	11,500	20,820
Deferred revenue	13,381	8,057
Deferred compensation	2,311	2,525
Accrued restructuring	4,604	6
Accrued transaction processing	1,492	3,257
Other	30,095	27,823
Total	$ 171,351	$ 166,495