-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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<SEC-DOCUMENT>0001181431-11-000436.txt : 20110103
<SEC-HEADER>0001181431-11-000436.hdr.sgml : 20101231
<ACCEPTANCE-DATETIME>20110103181357
ACCESSION NUMBER:		0001181431-11-000436
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20101230
FILED AS OF DATE:		20110103
DATE AS OF CHANGE:		20110103

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			FRANCO RICHARD A
		CENTRAL INDEX KEY:			0001212673

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-23776
		FILM NUMBER:		11502885

	MAIL ADDRESS:	
		STREET 1:		8540 COLONNADE CENTER DRIVE
		STREET 2:		SUITE 501
		CITY:			RALEIGH
		STATE:			NC
		ZIP:			27615

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			DARA BioSciences, Inc.
		CENTRAL INDEX KEY:			0000919745
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				043216862
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		8601 SIX FORKS ROAD SUITE 160
		CITY:			RALEIGH
		STATE:			NC
		ZIP:			27615
		BUSINESS PHONE:		919-861-0202

	MAIL ADDRESS:	
		STREET 1:		8601 SIX FORKS ROAD SUITE 160
		CITY:			RALEIGH
		STATE:			NC
		ZIP:			27615

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	DARA BIOSCIENCES INC
		DATE OF NAME CHANGE:	20080211

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	POINT THERAPEUTICS INC
		DATE OF NAME CHANGE:	20020328

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	HMSR INC
		DATE OF NAME CHANGE:	20010618
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>rrd295943.xml
<DESCRIPTION>FRANCO PREFERRED STOCK PURCHASE (DEC. 2010)
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0303</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2010-12-30</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0000919745</issuerCik>
        <issuerName>DARA BioSciences, Inc.</issuerName>
        <issuerTradingSymbol>DARA</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001212673</rptOwnerCik>
            <rptOwnerName>FRANCO RICHARD A</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O DARA BIOSCIENCES, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>8601 SIX FORKS ROAD, SUITE 160</rptOwnerStreet2>
            <rptOwnerCity>RALEIGH</rptOwnerCity>
            <rptOwnerState>NC</rptOwnerState>
            <rptOwnerZipCode>27615</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>President &amp; CEO</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>112835</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <derivativeTable>
        <derivativeTransaction>
            <securityTitle>
                <value>Series A Convertible Preferred Stock</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>2.50</value>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2010-12-30</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>P</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>200</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>1000</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <footnoteId id="F1"/>
            </exerciseDate>
            <expirationDate>
                <footnoteId id="F1"/>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>80000</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>80000</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeTransaction>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">Series A convertible preferred stock is convertible into common stock at any time at a rate of 400-for-1 and has no expiration date.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Richard A. Franco by Mark R. Busch, Attorney-in-Fact</signatureName>
        <signatureDate>2011-01-03</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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