X0306 4 2012-12-06 0 0000919722 Astex Pharmaceuticals, Inc ASTX 0001525784 Buckland Martin C/O ASTEX PHARMACEUTICALS 436 CAMBRIDGE SCIENCE PARK MILTON ROAD CAMBRIDGE X0 CB4 0QA UNITED KINGDOM 0 1 0 0 Chief Business Officer Employee Stock Option (Right to buy) 2.71 2012-12-06 4 A 0 180000 0 A 2022-12-06 Common Stock 180000 180000 D Grant to reporting person of option to purchase shares of Common Stock under the Issuer's 2003 Stock Plan. The option vests and becomes exercisable as to 1/48th of the shares on January 6, 2013 and at the end of each full month thereafter. /s/ Martin Buckland 2012-12-10