X0202 4 2006-05-11 0 0000919722 SUPERGEN INC SUPG 0001236365 MANUSO JAMES S J C/O SUPERGEN, INC. 4140 DUBLIN BOULEVARD, SUITE 200 DUBLIN CA 94568 1 1 0 0 President/CEO Employee Stock Option (Right to buy) 11.27 2006-05-11 4 A 0 250000 0 A 2006-05-11 2014-01-02 Common Stock 250000 250000 D On January 2, 2004, reporting person was granted an option to buy 1,000,000 shares of Common Stock under the Issuer's 2003 Stock Plan. 250,000 of the shares subject to such option grant were to vest upon satisfaction of certain performance milestones. On May 11, 2006 these performance milestones were deemed to have been met and the 250,00 option shares became vested. /s/ James S.J. Manuso 2006-05-15