CONSOLIDATED STATEMENTS OF OPERATIONS (USD $) In Thousands, except Per Share data, unless otherwise specified	12 Months Ended
	Dec. 31, 2012	Dec. 31, 2011	Dec. 31, 2010
Revenues:
Royalty revenue	$ 71,091	$ 60,519	$ 52,463
Development and license revenue	12,068	6,395	509
Total revenues	83,159	66,914	52,972
Operating expenses:
Research and development	60,418	43,895	28,394
General and administrative	15,662	16,842	9,442
Amortization of intangibles	8,005	3,215
Impairment of intangibles	7,402	1,250
Gains on disposition of certain assets and sale of products	(1,276)	(700)	(750)
Total operating expenses	90,211	64,502	37,086
Income (loss) from operations	(7,052)	2,412	15,886
Interest income	188	226	182
Gain (loss) on sale of investments and fixed assets	2,583	(75)
Other than temporary decline in value of investments	(524)
Other income (expense)	20	(309)	244
Income (loss) before income taxes	(4,785)	2,254	16,312
Income tax benefit (provision)	13,032	3,288	(39)
Net income	$ 8,247	$ 5,542	$ 16,273
Net income per common share:
Basic (in dollars per share)	$ 0.09	$ 0.07	$ 0.27
Diluted (in dollars per share)	$ 0.08	$ 0.07	$ 0.27
Weighted average shares outstanding:
Basic (in shares)	93,264	75,072	60,287
Diluted (in shares)	101,987	75,751	60,635