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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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 YY8J2Df0Bmj+UcLWY7s2SQ==

<SEC-DOCUMENT>0001181431-03-035114.txt : 20031211
<SEC-HEADER>0001181431-03-035114.hdr.sgml : 20031211
<ACCEPTANCE-DATETIME>20031211131058
ACCESSION NUMBER:		0001181431-03-035114
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20031209
FILED AS OF DATE:		20031211

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			BIOSPHERE MEDICAL INC
		CENTRAL INDEX KEY:			0000919015
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				043216867
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		1050 HINGHAM STREET
		CITY:			ROCKLAND
		STATE:			MA
		ZIP:			02370
		BUSINESS PHONE:		7816817900

	MAIL ADDRESS:	
		STREET 1:		1050 HINGHAM STREET
		CITY:			ROCKLAND
		STATE:			MA
		ZIP:			02370

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	BIOSEPRA INC
		DATE OF NAME CHANGE:	19940215

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			COUSINS WILLIAM JR
		CENTRAL INDEX KEY:			0001228513

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-23678
		FILM NUMBER:		031049091

	BUSINESS ADDRESS:	
		STREET 1:		6075 PELICAN BAY BLVD #1403
		CITY:			NAPLES
		STATE:			FL
		ZIP:			34108
		BUSINESS PHONE:		2395982724

	MAIL ADDRESS:	
		STREET 1:		6075 PELICAN BAY BLVD #1403
		CITY:			NAPLES
		STATE:			FL
		ZIP:			34108
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>rrd25266.xml
<DESCRIPTION>FORM 4
<TEXT>
<XML>
<?xml version="1.0"?><ownershipDocument>
    <schemaVersion>X0201</schemaVersion>

    <documentType>4</documentType><periodOfReport>2003-12-09</periodOfReport><notSubjectToSection16>0</notSubjectToSection16>
    <issuer>
        <issuerCik>0000919015</issuerCik>
        <issuerName>BIOSPHERE MEDICAL INC</issuerName>
        <issuerTradingSymbol>BSMD</issuerTradingSymbol></issuer><reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001228513</rptOwnerCik>
            <rptOwnerName>COUSINS WILLIAM JR</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>6075 PELICAN BAY BLVD</rptOwnerStreet1>
            <rptOwnerStreet2># 1403</rptOwnerStreet2>
            <rptOwnerCity>NAPLES</rptOwnerCity>
            <rptOwnerState>FL</rptOwnerState>
            <rptOwnerZipCode>34108</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
            <reportingOwnerRelationship>
<isDirector>1</isDirector><isOfficer>0</isOfficer><isTenPercentOwner>0</isTenPercentOwner><isOther>0</isOther></reportingOwnerRelationship></reportingOwner><nonDerivativeTable><nonDerivativeTransaction><securityTitle><value>Common Stock of BioSphere Medical Inc.</value></securityTitle><transactionDate><value>2003-12-09</value></transactionDate><transactionCoding><transactionFormType>4</transactionFormType><transactionCode>S</transactionCode><equitySwapInvolved>0</equitySwapInvolved></transactionCoding><transactionAmounts><transactionShares><value>6000</value></transactionShares><transactionPricePerShare><value>3.25</value></transactionPricePerShare><transactionAcquiredDisposedCode><value>D</value></transactionAcquiredDisposedCode></transactionAmounts><postTransactionAmounts><sharesOwnedFollowingTransaction><value>0</value></sharesOwnedFollowingTransaction></postTransactionAmounts><ownershipNature><directOrIndirectOwnership><value>D</value></directOrIndirectOwnership></ownershipNature></nonDerivativeTransacti
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><transactionCoding><transactionFormType>4</transactionFormType><transactionCode>S</transactionCode><equitySwapInvolved>0</equitySwapInvolved></transactionCoding><transactionAmounts><transactionShares><value>300</value></transactionShares><transactionPricePerShare><value>3.29</value></transactionPricePerShare><transactionAcquiredDisposedCode><value>D</value></transactionAcquiredDisposedCode></transactionAmounts><postTransactionAmounts><sharesOwnedFollowingTransaction><value>0</value></sharesOwnedFollowingTransaction></postTransactionAmounts><ownershipNature><directOrIndirectOwnership><value>D</value></directOrIndirectOwnership></ownershipNature></nonDerivativeTransaction><nonDerivativeTransaction><securityTitle><value>Common Stock of BioSphere Medical Inc.</value></securityTitle><transactionDate><value>2003-12-09</value></transactionDate><transactionCoding><transactionFormType>4</transactionFormType><transactionCode>S</transactionCode><equitySwapInvolved>0</equitySwapInvolved></transactionCoding><transaction
Amounts><transactionShares><value>200</value></transactionShares><transactionPricePerShare><value>3.30</value></transactionPricePerShare><transactionAcquiredDisposedCode><value>D</value></transactionAcquiredDisposedCode></transactionAmounts><postTransactionAmounts><sharesOwnedFollowingTransaction><value>0</value></sharesOwnedFollowingTransaction></postTransactionAmounts><ownershipNature><directOrIndirectOwnership><value>D</value></directOrIndirectOwnership></ownershipNature></nonDerivativeTransaction><nonDerivativeTransaction><securityTitle><value>Common Stock of BioSphere Medical Inc.</value></securityTitle><transactionDate><value>2003-12-09</value></transactionDate><transactionCoding><transactionFormType>4</transactionFormType><transactionCode>S</transactionCode><equitySwapInvolved>0</equitySwapInvolved></transactionCoding><transactionAmounts><transactionShares><value>1200</value></transactionShares><transactionPricePerShare><value>3.33</value></transactionPricePerShare><transactionAcquiredDisposedCode><va
lue>D</value></transactionAcquiredDisposedCode></transactionAmounts><postTransactionAmounts><sharesOwnedFollowingTransaction><value>0</value></sharesOwnedFollowingTransaction></postTransactionAmounts><ownershipNature><directOrIndirectOwnership><value>D</value></directOrIndirectOwnership></ownershipNature></nonDerivativeTransaction><nonDerivativeTransaction><securityTitle><value>Common Stock of BioSphere Medical Inc.</value></securityTitle><transactionDate><value>2003-12-09</value></transactionDate><transactionCoding><transactionFormType>4</transactionFormType><transactionCode>S</transactionCode><equitySwapInvolved>0</equitySwapInvolved></transactionCoding><transactionAmounts><transactionShares><value>500</value></transactionShares><transactionPricePerShare><value>3.35</value></transactionPricePerShare><transactionAcquiredDisposedCode><value>D</value></transactionAcquiredDisposedCode></transactionAmounts><postTransactionAmounts><sharesOwnedFollowingTransaction><value>0</value></sharesOwnedFollowingTransaction
></postTransactionAmounts><ownershipNature><directOrIndirectOwnership><value>D</value></directOrIndirectOwnership></ownershipNature></nonDerivativeTransaction><nonDerivativeTransaction><securityTitle><value>Common Stock of BioSphere Medical Inc.</value></securityTitle><transactionDate><value>2003-12-09</value></transactionDate><transactionCoding><transactionFormType>4</transactionFormType><transactionCode>S</transactionCode><equitySwapInvolved>0</equitySwapInvolved></transactionCoding><transactionAmounts><transactionShares><value>4100</value></transactionShares><transactionPricePerShare><value>3.40</value></transactionPricePerShare><transactionAcquiredDisposedCode><value>D</value></transactionAcquiredDisposedCode></transactionAmounts><postTransactionAmounts><sharesOwnedFollowingTransaction><value>0</value></sharesOwnedFollowingTransaction></postTransactionAmounts><ownershipNature><directOrIndirectOwnership><value>D</value></directOrIndirectOwnership></ownershipNature></nonDerivativeTransaction></nonDerivativ
eTable><ownerSignature><signatureName>/s/ William M. Cousins Jr.</signatureName><signatureDate>2003-12-10</signatureDate></ownerSignature></ownershipDocument>



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