X0303 4 2010-09-10 1 0000919015 BIOSPHERE MEDICAL INC BSMD 0001198220 HEARD MARIAN L C/O BIOSPHERE MEDICAL, INC. 1050 HINGHAM STREET ROCKLAND MA 02370 1 0 0 0 Common Stock 2010-09-10 4 D 0 7500 4.38 D 0 D Common Stock Option 3.82 2010-09-10 4 D 0 5000 0 D 2018-05-14 Common Stock 5000 0 D Common Stock Option 1.90 2010-09-10 4 D 0 5000 0 D 2019-05-14 Common Stock 5000 0 D Reflects shares of common stock that were exchanged for a cash payment of $4.38 per share in connection with the merger (the "Merger") of Merit BioAcquisition Co. with and into BioSphere Medical, Inc. This option was cancelled in connection with the Merger in exchange for a cash payment per underlying share equal to the difference between the exercise price and $4.38. /s/ Martin J. Joyce, by power of attorney for Marian L. Heard 2010-09-10