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CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($)
shares in Thousands, $ in Thousands
12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Income Statement [Abstract]      
Total revenue, net $ 1,542,448 $ 1,371,868 $ 1,517,557
Costs and expenses:      
Cost of goods sold 597,808 520,834 564,681
Research and development 93,051 77,381 79,573
In-process research and development 0 0 64,916
Selling, general and administrative 637,445 594,526 687,599
Intangible asset amortization 16,914 27,757 27,028
Total costs and expenses 1,345,218 1,220,498 1,423,797
Operating income 197,230 151,370 93,760
Interest income 6,737 9,297 10,779
Interest expense (50,395) (71,581) (53,957)
Gain from sale of business 41,798 0 0
Other income, net 19,307 4,434 9,522
Income before income taxes 214,677 93,520 60,104
Provision (benefit) for income taxes 45,602 (40,372) 9,903
Net income $ 169,075 $ 133,892 $ 50,201
Net income per share      
Basic (in dollars per share) $ 2.00 $ 1.58 $ 0.59
Diluted (in dollars per share) $ 1.98 $ 1.57 $ 0.58
Weighted average common shares outstanding (See Note 13):      
Basic (in shares) 84,698 84,650 85,637
Diluted (in shares) 85,485 85,228 86,494