Income Taxes (Details 4) - USD ($) $ in Thousands	Dec. 31, 2024	Dec. 31, 2023
Components of net deferred tax assets (liabilities)
Lease liabilities	$ 6,384	$ 6,607
Other timing differences, accruals and reserves	3,893	5,306
Deferred equity compensation	6,678	3,973
Net operating loss carryovers	12,003	14,578
Capitalized research	96,739	77,244
Tax credits	47,960	50,445
Total gross deferred tax assets	173,657	158,153
Lease right-of-use assets	(4,498)	(4,589)
Depreciation and amortization	(9,077)	(5,078)
Total gross deferred tax liabilities	(13,575)	(9,667)
Total net deferred tax assets before valuation allowance	160,082	148,486
Valuation allowance	(26,790)	(25,056)
Net deferred tax assets	$ 133,292	$ 123,430