CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2024	Dec. 31, 2023	Dec. 31, 2022
Revenue
Revenue	$ 556,624	$ 461,117	$ 454,793
Cost of revenue
Cost of product revenue	95,875	84,495	88,976
Cost of contract and other revenue	3,028	5,403	4,668
Amortization of acquired intangible assets	11,204	13,524	13,935
Cost of revenue	110,107	103,422	107,579
Gross profit	446,517	357,695	347,214
Operating expenses
Research and development	162,881	156,827	158,769
Sales, general and administrative	104,094	108,149	106,718
Amortization of acquired intangible assets	506	1,217	1,674
Restructuring and other charges	0	9,368	0
Gain on divestiture	0	(90,784)	0
Impairment of assets	1,071	10,045	0
Change in fair value of earn-out liability	(5,044)	9,234	3,111
Total operating expenses	263,508	204,056	270,272
Operating income	183,009	153,639	76,942
Interest income and other income (expense), net	18,450	11,327	7,771
Gain on sale of equity security	0	0	3,547
Loss on extinguishment of debt	0	0	(83,626)
Loss on fair value adjustment of derivatives, net	0	(240)	(10,585)
Gain on sale of non-marketable equity security	0	23,924	0
Interest Expense, Nonoperating	1,416	1,490	1,874
Interest and other income (expense), net	17,034	33,521	(84,767)
Income (loss) before income taxes	200,043	187,160	(7,825)
Provision for (benefit from) income taxes	20,222	(146,744)	6,485
Net income (loss)	$ 179,821	$ 333,904	$ (14,310)
Net income (loss) per share:
Basic net income (loss) per share	$ 1.67	$ 3.09	$ (0.13)
Diluted net income (loss) per share	$ 1.65	$ 3.01	$ (0.13)
Weighted-average shares used in per share calculations:
Basic (in shares)	107,438	108,183	109,472
Diluted (in shares)	109,041	110,889	109,472
Product revenue
Revenue
Revenue	$ 246,815	$ 224,632	$ 227,068
Royalties
Revenue
Revenue	226,172	150,110	139,816
Contract and other revenue
Revenue
Revenue	$ 83,637	$ 86,375	$ 87,909