CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Thousands, $ in Thousands		3 Months Ended		9 Months Ended
		Sep. 30, 2019	Sep. 30, 2018	Sep. 30, 2019	Sep. 30, 2018
Revenue
Revenue		$ 57,399	$ 59,754	$ 164,080	$ 162,638
Operating costs and expenses:
Cost of product revenue	[1]	7,108	5,376	17,845	13,932
Cost of contract and other revenue		5,466	5,952	18,954	29,163
Research and development	[1]	41,486	43,131	119,995	120,944
Sales, general and administrative	[1]	26,691	24,462	79,244	79,143
Restructuring charges (recoveries)		1,374	0	4,233	2,223
Impairment of assets held for sale		(1,853)	0	15,137	0
Total operating costs and expenses		80,272	78,921	255,408	245,405
Operating income (loss)		(22,873)	(19,167)	(91,328)	(82,767)
Interest income and other income (expense), net		6,727	8,008	21,112	25,373
Interest expense		(2,497)	(3,976)	(7,302)	(13,031)
Interest and other income (expense), net		4,230	4,032	13,810	12,342
Loss before income taxes		(18,643)	(15,135)	(77,518)	(70,425)
Provision for (benefit from) income taxes		(1,312)	89,758	3,369	85,514
Net income (loss)		$ (17,331)	$ (104,893)	$ (80,887)	$ (155,939)
Net loss per share:
Earnings per share, basic		$ (0.16)	$ (0.97)	$ (0.73)	$ (1.44)
Earnings per share, diluted		$ (0.16)	$ (0.97)	$ (0.73)	$ (1.44)
Weighted average shares used in per share calculation:
Basic (in shares)		111,315	107,897	110,633	108,324
Diluted (in shares)		111,315	107,897	110,633	108,324
Royalties
Revenue
Revenue		$ 19,448	$ 33,599	$ 71,351	$ 85,022
Product revenue
Revenue
Revenue		21,377	11,753	46,372	27,153
Contract and other revenue
Revenue
Revenue		$ 16,574	$ 14,402	$ 46,357	$ 50,463

[1] Includes stock-based compensation: Cost of product revenue $ 2
  $ 2
  $ 4
  $ 7
Research and development $ 3,008
  $ 3,184
  $ 9,276
  $ 9,662
Sales, general and administrative $ 4,378
  $ 3,003
  $ 12,377
  $ 5,922